ChemicalBook > CAS DataBase List > CCT129202

CCT129202

Product Name: CCT129202
CAS No.: 942947-93-5
Chemical Name: CCT129202
Synonyms: CS-407;CCT129202;CCT129202 USP/EP/BP;CCT129202 (CCT-129202;2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(th;1-Piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-;2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide
CBNumber: CB02561464
Molecular Formula: C23H25ClN8OS
Formula Weight: 497.02
MOL File: 942947-93-5.mol

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CCT129202 Property

Density: 1.427
storage temp.: Store at -20°C
solubility: DMSO : 1 mg/mL (2.01 mM; Need ultrasonic)
form: Powder
pka: 9.26±0.50(Predicted)
color: Light yellow to yellow
InChIKey: QYKHWEFPFAGNEV-UHFFFAOYSA-N
SMILES: N1(CC(NC2=NC=CS2)=O)CCN(C2C(Cl)=CN=C3NC(C4=CC=C(N(C)C)C=C4)=NC3=2)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29053
Product name: CCT129202
Packaging: 1mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 29053
Product name: CCT129202
Packaging: 10mg
Price: $365
Updated: 2024/03/01

Cayman Chemical

Product number: 29053
Product name: CCT129202
Packaging: 5mg
Price: $195
Updated: 2024/03/01

ChemScene

Product number: CS-0206
Product name: CCT129202
Purity: 98.24%
Packaging: 100mg
Price: $935
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000931
Product name: CCT-129202
Purity: 95.00%
Packaging: 10MG
Price: $1127.86
Updated: 2021/12/16

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CCT129202 Chemical Properties,Usage,Production

Uses

CCT129202 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.

Biological Activity

CCT129202 is an ATP-competitive pan-Aurora inhibitor with IC50s of 0.042 μM, 0.198 μM and 0.227 μM for Aurora A, Aurora B and Aurora C, respectively, and has a weaker effect on FGFR3, GSK3β, PDGFRβ, etc.

in vivo

CCT129202 at a dose of 100 mg/kg subcutaneously injected HCT116 colon xenografts in athymic mice, after 30 minutes, caused a ~50% decrease in histone H3 phosphorylation, and after 9 days of treatment, significantly inhibited tumor growth, compared with the control group , inhibited by 57.7%.

target

Aurora A

IC 50

Aurora A: 42 nM (IC₅₀); Aurora B: 198 nM (IC₅₀); Aurora C: 227 nM (IC₅₀)

References

[1] Chan F, et al. Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57. DOI:10.1158/1535-7163.MCT-07-2156

CCT129202 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CCT129202 manufacturers

Career Henan Chemical Co

Product: CCT129202 942947-93-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-08

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CCT129202

2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide

2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(th

CCT129202 (CCT-129202

CS-407

CCT129202 USP/EP/BP

1-Piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-

942947-93-5

C23H25ClN8OS

Inhibitor

Inhibitors