ChemicalBook > CAS DataBase List > CCT129202

CCT129202

Product Name
CCT129202
CAS No.
942947-93-5
Chemical Name
CCT129202
Synonyms
CS-407;CCT129202;CCT129202 USP/EP/BP;CCT129202 (CCT-129202;2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(th;1-Piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-;2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide
CBNumber
CB02561464
Molecular Formula
C23H25ClN8OS
Formula Weight
497.02
MOL File
942947-93-5.mol
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CCT129202 Property

Density 
1.427
storage temp. 
Store at -20°C
solubility 
DMSO : 1 mg/mL (2.01 mM; Need ultrasonic)
form 
Powder
pka
9.26±0.50(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29053
Product name
CCT129202
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
29053
Product name
CCT129202
Packaging
10mg
Price
$365
Updated
2024/03/01
Cayman Chemical
Product number
29053
Product name
CCT129202
Packaging
5mg
Price
$195
Updated
2024/03/01
ChemScene
Product number
CS-0206
Product name
CCT129202
Purity
98.24%
Packaging
100mg
Price
$935
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000931
Product name
CCT-129202
Purity
95.00%
Packaging
10MG
Price
$1127.86
Updated
2021/12/16
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CCT129202 Chemical Properties,Usage,Production

Biological Activity

CCT129202 is an ATP-competitive pan-Aurora inhibitor with IC50s of 0.042 μM, 0.198 μM and 0.227 μM for Aurora A, Aurora B and Aurora C, respectively, and has a weaker effect on FGFR3, GSK3β, PDGFRβ, etc.

in vivo

CCT129202 at a dose of 100 mg/kg subcutaneously injected HCT116 colon xenografts in athymic mice, after 30 minutes, caused a ~50% decrease in histone H3 phosphorylation, and after 9 days of treatment, significantly inhibited tumor growth, compared with the control group , inhibited by 57.7%.

target

Aurora A

CCT129202 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT129202 Suppliers

China 79 United States 13 Global 92
Shanghai Shiyi Reagent Co., Ltd
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NCE Biomedical Co.,Ltd.
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DC Chemicals
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View Lastest Price from CCT129202 manufacturers

Career Henan Chemical Co
Product
CCT129202 942947-93-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

942947-93-5, CCT129202Related Search:

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  • CCT129202
  • 2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide
  • 2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(th
  • CCT129202 (CCT-129202
  • CS-407
  • CCT129202 USP/EP/BP
  • 1-Piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-
  • 942947-93-5
  • C23H25ClN8OS
  • Inhibitor
  • Inhibitors