Pyridoxal phosphate

Product Name: Pyridoxal phosphate
CAS No.: 54-47-7
Chemical Name: Pyridoxal phosphate
Synonyms: Pyridoxal-5-phosphat;PYRIDOXINEPHOSPHATE;PYRIDOXAL 5'-MONOPHOSPHATE;pal-p;P-5-P;piodel;Pydoxa;Aderol;pydoxal;Navisal
CBNumber: CB0257385
Molecular Formula: C8H10NO6P
Formula Weight: 247.14
MOL File: 54-47-7.mol

More

Less

Pyridoxal phosphate Property

Melting point:: 140-143 °C
Boiling point:: 565.7±60.0 °C(Predicted)
Density: 1.638±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
pka: 1.56±0.10(Predicted)
form: powder
color: Off-white to yellow
Stability:: Hygroscopic
InChI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKey: NGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES: C1(C)=NC=C(COP(O)(O)=O)C(C=O)=C1O
LogP: -1.921 (est)
CAS DataBase Reference: 54-47-7(CAS DataBase Reference)
EPA Substance Registry System: 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]- (54-47-7)

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 8-10-23
HS Code: 29362500

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TRC

Product number: P991715
Product name: Pyridoxal5''-Phosphate
Packaging: 1g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 0135CA
Product name: Pyridoxalphosphate
Packaging: 250mg
Price: $68
Updated: 2021/12/16

ChemScene

Product number: CS-7767
Product name: Pyridoxalphosphate
Purity: ≥98.0%
Packaging: 1g
Price: $84
Updated: 2021/12/16

Ark Pharm

Product number: P000723830
Product name: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
Purity: 98%
Packaging: 100g
Price: $132
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003990
Product name: PYRIDOXALE-5-PHOSPHATE
Purity: 95.00%
Packaging: 1G
Price: $132.3
Updated: 2021/12/16

More

Less

Pyridoxal phosphate Chemical Properties,Usage,Production

Description

Pyridoxal phosphate is an organic compound formed by the combination of vitamin B6 and phosphoric acid, including pyridoxal, pyridoxamine, and pyridoxine, which exist in the form of phosphate esters in the body. Among them, pyridoxal phosphate and pyridoxamine phosphate can be converted into each other, and they are all active types. Pyridoxal phosphate is the active form of vitamin B6. Several reactions catalyzed by pyridoxal phosphate are: transamination, α-decarboxylation, β-decarboxylation, β-elimination, γ-elimination, racemization and aldol reaction.

Chemical Properties

Light yellow crystalline

Uses

Vitamin (enzyme co-factor).

Definition

Pyridoxal Phosphate also known as PLP, pyridoxal 5'-phosphate or P5P, is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.

Biological Functions

Pyridoxal phosphate is the coenzyme form of vitamin B6. In the catalytic reaction, the intramolecular aldehyde group of pyridoxal phosphate is combined with the amino group of α-amino acid to form an aldimine, also known as Schiffbase, and then the amino acid undergoes transamination, decarboxylation or racemization according to the characteristics of different enzymes and proteins. . As a coenzyme of amino acid transaminase, decarboxylase and racemase, it plays a very important role in amino acid metabolism.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 4693, 1951 DOI: 10.1021/ja01154a062

Mechanism of action

Pyridoxal phosphate(PLP) acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids. The aldehyde group of PLP forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue in a process known as transaldimination. The resulting external aldimine can lose a proton, carbon dioxide, or an amino acid sidechain to become a quinoid intermediate, which in turn can act as a nucleophile in several reaction pathways.

Purification Methods

PLP has been purified by dissolving 2g in H2O (10-15mL, in a dialysis bag a third full) and dialysing with gentle stirring against 1L of H2O (+ two drops of toluene) for 15hours in a cold room. The dialysate is evaporated to 80-100mL, then lyophilised. Lemon yellow microscopic needles of the monohydrate remain when all the ice crystals have been removed. The purity is checked by paper chromatography (in EtOH or n-PrOH/NH3) and the spot(s) visualised under UV light after reaction with a spray of p-phenylene diamine, NH3 and molybdate. Solutions stored in a freezer are 2-3% hydrolysed in 3weeks. At 25o, only 4-6% hydrolysis occurs even in N NaOH or HCl, and 2% is hydrolysed at 37o in 1day-but is complete at 100o in 4hours. It is best stored as a dry solid at -20o. In aqueous acid the solution is colourless but is yellow in alkaline solutions. It has UV max at 305nm ( 1100) and 380nm ( 6550) in 0.1 N NaOH; 330nm ( 2450) and 388nm ( 4,900) in 0.05M phosphate buffer pH 7.0 and 295nm ( 6700) in 0.1N HCl. [Peterson et al. Biochemical Preparations 3 34, 119 1953.] The oxime decomposes at 229-230o and is practically insoluble in H2O, EtOH and Et2O. The O-methyloxime decomposes at 212-213o. [Heyl et al. J Am Chem Soc 73 3430 1951.] It has also been purified by column chromatography through Amberlite IRC-50 (H+) [Peterson & Sober J Am Chem Soc 76 169 1954]. [Beilstein 21/13 V 46.]

Pyridoxal phosphate Preparation Products And Raw materials

Raw materials

Manganese dioxide Pyridoxine Phosphorus pentoxide Pyridoxamine dihydrochloride SULPHOSUCCINIC ACID ESTER

Preparation Products

4-Deoxypyridoxine hydrochloride

More

Less

Pyridoxal phosphate Suppliers

Canada 1 China 310 Europe 2 Germany 2 India 9 Italy 1 Switzerland 1 United Kingdom 6 United States 33 Global 365

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
Country: United States
ProdList: 9171
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Alfa Chemistry

Tel
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 24072
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Creative Enzymes

Tel: 1-516-855-7709
Fax: 1-631-938-8127
Email: info@creative-enzymes.com
Country: United States
ProdList: 8748
Advantage: 58

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

American International Chemical, Inc.

Tel: --
Fax: --
Email: info@aicma.com
Country: United States
ProdList: 531
Advantage: 58

Charkit Chemical Corporation

Tel: --
Fax: --
Email: sales@charkit.com
Country: United States
ProdList: 2993
Advantage: 65

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

AppliChem, LLC

Tel: --
Fax: --
Email: sales@applichem.com
Country: United States
ProdList: 169
Advantage: 50

Bosgen Chemical Inc.

Tel: --
Fax: --
Email: sale@chemapi.com
Country: United States
ProdList: 609
Advantage: 30

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

City Chemical LLC

Tel: --
Fax: --
Email: sales@citychemical.com
Country: United States
ProdList: 6708
Advantage: 72

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Aceto Corporation

Tel: --
Fax: --
Email: contact@aceto.com
Country: United States
ProdList: 2619
Advantage: 75

ChromaDex

Tel: --
Fax: --
Email: sales@chromadex.com
Country: United States
ProdList: 2501
Advantage: 76

Chem-Impex International, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6730
Advantage: 64

Pfaltz & Bauer, Inc.

Tel: --
Fax: --
Email: sales@pfaltzandbauer.com
Country: United States
ProdList: 6828
Advantage: 72

Research Plus, Inc.

Tel: --
Fax: --
Email: respls@aol.com
Country: United States
ProdList: 3674
Advantage: 51

Research Organics Inc.

Tel: --
Fax: --
Email: info@resorg.com
Country: United States
ProdList: 1324
Advantage: 72

City Chemicals Corporation

Tel: --
Fax: --
Country: United States
ProdList: 6460
Advantage: 72

Scandinavian Formulas, Inc.

Tel: --
Fax: --
Email: info@scandinavianformulas.com
Country: United States
ProdList: 1447
Advantage: 55

EMD Biosciences, Inc.

Tel: --
Fax: --
Email: technical@calbiochem.com
Country: United States
ProdList: 6529
Advantage: 66

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

More

Less

View Lastest Price from Pyridoxal phosphate manufacturers

Sinoway Industrial co., ltd.

Product: Pyridoxal phosphate 54-47-7
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 98.5% up / EP
Supply Ability: 20 tons
Release date: 2024-06-27

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Pyridoxal phosphate 54-47-7
Price: US $500.00-300.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-23

Wuhan Haorong Biotechnology Co.,Ltd

Product: Pyridoxal phosphate 54-47-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000
Release date: 2023-08-11

54-47-7, Pyridoxal phosphateRelated Search:

CHLOROPHOSPHONAZO III Hydrogen (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one 4-Methylpyridine Sodium phosphate tribasic dodecahydrate 2,6-Lutidine 2-Chloro-5-chloromethylpyridine Pyridoxal hydrochloride Azamethiphos pyridoxal Ammonium phosphate dibasic SULPHOSUCCINIC ACID ESTER Alkaline Phosphatase Trisodium phosphate Dimethyldimethoxysilane Bensulfuron methyl Methyltriethoxysilane phosphate ester starch

PYRIDOXAL-5-PHOSPHORIC ACID

PYRIDOXAL 5'-MONOPHOSPHATE

CODECARBOXYLASE

3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehyd

3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyd

apolonb(sub6)

apolonb6

biosechs

hairoxal

hexerminp

hiadelon

hi-pyridoxin

pal-p

phosphopyridoxal

phosphoridoxalcoenzyme

piodel

pydoxal

pyridoxaldehydephosphate

pyridoxalmonophosphate

pyridoxalp

pyridoxylphosphate

pyromijin

sechvitan

vitahexinp

vitazechs

Pyridoxal-5-phosphat

PYRIDOXAL-5-PHOSPHATE(P)

(3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methyl phosphate

Pyridoxal-5'-Phosphate~99%

Pyridoxal-5-Phosphate99.0%Min.

VitaminB6phosphate

Pyridoxal 5'-(dihydrogen phosphate)

Pyridoxal phosphate

Codecarboxylase PLP

2-Methyl-3-hydroxy-4-formyl-5-pyridylmethylphosphoric acid

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate

4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-

Coenzyme B6

Pydoxa

Aderol

Navisal

Neoaderol

Pyridoxal-5-phosphate(P5P)

3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde

P-5-P

(4-formyl-5-hydroxy-6-methyl-pyridin-3-yl)methoxyphosphonic acid

PYRIDOXINEPHOSPHATE

Pyridoxal 5-phosphate (methyl-D3)

Pyridoxal phosphate（PLP）

5-Pyridoxal phosphate

Pyridoxal phosphate USP/EP/BP

Pyridoxal phosphate/P5P

Pyridoxal phosphate API

Pyridoxal5′-phosphate 5

Pyridoxal 5'-phosphate(P5P)

Cymoxanil Impurity 1

Pyridoxal 5-Phosphate in Water:Acetonitrile=8:2

54-47-7