ChemicalBook > CAS DataBase List > N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE

N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE

Product Name
N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE
CAS No.
5472-49-1
Chemical Name
N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE
Synonyms
PIPERIDINOPROPYL CHLORIDE HCL;N-(3-CHLOROPROPYL)PIPERIDINE HCL;1-(3-CHLOROPROPYL)PIPERIDINE HCL 98%;piperidinopropylchloride,hydrochloride;1-(3-CHLOROPROPYL) PIPERIDINE HYDROCHLO&;1-(3-chloropropyl)-piperidinhydrochloride;3-Piperidinopropyl Chloride Hydrochloride;N-(3-CHLOROPROPYL)PIPERIDINE?HYDROCHLORID;1-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE;N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE
CBNumber
CB0258362
Molecular Formula
C8H17Cl2N
Formula Weight
198.13
MOL File
5472-49-1.mol
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N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE Property

Melting point:
219-223 °C(lit.)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Water Solubility 
Soluble in water
form 
Powder or Crystalline Powder
color 
White to yellow
InChI
InChI=1S/C8H16ClN.ClH/c9-5-4-8-10-6-2-1-3-7-10;/h1-8H2;1H
InChIKey
OBOBUDMMFXRNDO-UHFFFAOYSA-N
SMILES
N1(CCCCl)CCCCC1.Cl
CAS DataBase Reference
5472-49-1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TM6498600
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
596310
Product name
1-(3-Chloropropyl)piperidine monohydrochloride
Purity
97%
Packaging
10g
Price
$166
Updated
2023/06/20
TCI Chemical
Product number
C2922
Product name
1-(3-Chloropropyl)piperidine Hydrochloride
Purity
>98.0%(T)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
C2922
Product name
1-(3-Chloropropyl)piperidine Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$130
Updated
2025/07/31
TRC
Product number
C429300
Product name
1-(3-Chloropropyl)piperidine Hydrochloride
Packaging
2.5g
Price
$60
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK305007
Product name
1-(3-Chloropropyl)piperidine Hydrochloride
Purity
98%
Packaging
5g
Price
$84
Updated
2021/12/16
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N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

1-(3-Chloropropyl)piperidine Hydrochloride is used in preparation of Triazolotriazine derivatives as A2A receptor antagonists.

Synthesis

110-89-4

109-70-6

5472-49-1

Hexahydropyridine (piperidine, 0.45 g, 5.3 mmol) and 1-bromo-3-chloropropane (5.2 g, 33 mmol) were dissolved in toluene (17.5 mL) and then tetra-n-ammonium hydrogensulfate (ammonium hydrogensulfate, 0.51 g, 1.5 mmol) and 25% aqueous sodium hydroxide solution (10 mL) were added. The reaction mixture was stirred at 40 °C for 3 hours. After completion of the reaction, the mixture was cooled to room temperature, the toluene layer was separated, washed with saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. After removal of sodium sulfate by filtration, hydrochloric acid/methanol solution (2 mL) was added to the filtrate and the mixture was subsequently concentrated. The resulting crude product was purified by recrystallization from methanol/ether to give N-(3-chloropropyl)piperidine hydrochloride (0.96 g, 91% yield) as white crystals.

References

[1] Patent: US6642228, 2003, B1. Location in patent: Page/Page column 76-77

N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE Suppliers

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View Lastest Price from N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE 5472-49-1
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
500kg/month
Release date
2019-08-01

5472-49-1, N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDERelated Search:

Histamine dihydrochloride Piperidine hydrochloride N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE 3-Chloropropylamine hydrochloride 3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE 3-Chloro-1-(N,N-dimethyl)propylamine 3-DIETHYLAMINOPROPYL CHLORIDE ETHYL 1-(3-CHLOROPROPYL)-4-PHENYLPIPERIDINE-4-CARBOXYLATE HYDROCHLORIDE 3-DIETHYLAMINOPROPYL CHLORIDE HYDROCHLORIDE 1-(3-Chloropropyl)piperidine HCl N-METHYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE

  • N-(3-CHLOROPROPYL)PIPERIDINE HCL
  • N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE
  • PIPERIDINOPROPYL CHLORIDE HCL
  • 1-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE
  • 1-(3-chloropropyl)-piperidinhydrochloride
  • piperidinopropylchloride,hydrochloride
  • N-(3-Chloropropyl)piperidine hydrochloride,97%
  • 1-(3-CHLOROPROPYL) PIPERIDINE HYDROCHLO&
  • 1-(3-chloropropyl)piperidine monohydrochloride
  • 1-(3-CHLOROPROPYL)PIPERIDINE HCL 98%
  • 1-(3-Chloropropyl)piperidine monohydrochloride 97%
  • 1-(3-Chloropropyl)piperidine Hydrochloride &gt
  • Piperidine,1-(3-chloropropyl)-,hydrochloride(1:1)
  • 3-Piperidinopropyl Chloride Hydrochloride
  • 1-(3-Chloropropyl)piperidine hydrochloride (1:1)
  • N-(3-CHLOROPROPYL)PIPERIDINE?HYDROCHLORID
  • 5472-49-1
  • Piperidines
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Building Blocks
  • C5 to C9
  • C8
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Piperidines
  • PiperidinesHeterocyclic Building Blocks