Taccalonolide A

Product Name: Taccalonolide A
CAS No.: 108885-68-3
Chemical Name: Taccalonolide A
Synonyms: Rhizolactone A.;Taccalonolide A;ETaccalonolide A;Potato ketolide A;Taccalonolide A, 10 mM in DMSO;Microtubule/Tubulin,Apoptosis,inhibit,Inhibitor,Taccalonolide A;16,24-Cycloergost-22-en-26-oic acid, 1,11,12,15-tetrakis(acetyloxy)-2,3-epoxy-7,23,25-trihydroxy-6-oxo-, γ-lactone, (1α,2α,3α,5α,7β,11α,12α,15α,16β,24β,25S)-;(1alpha,2alpha,3alpha,5alpha,7beta,11alpha,12alpha,15alpha,16beta,24beta,25S)-1,11,12,15-Tetrakis(acetyloxy)-2,3-epoxy-7,23,25-trihydroxy-6-oxo-16,24-cycloergost-22-en-26-oic acid gamma-lactone
CBNumber: CB02610502
Molecular Formula: C36H46O14
Formula Weight: 702.74
MOL File: 108885-68-3.mol

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Taccalonolide A Property

Boiling point:: 776.8±60.0 °C(Predicted)
Density: 1.41±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 11.56±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: PTTJLTMUKRRHAT-VJAKQJMOSA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 301028
Product name: Taccalonolide A
Packaging: 20mg
Price: $638
Updated: 2021/12/16

ChemScene

Product number: CS-0022618
Product name: TaccalonolideA
Packaging: 10mg
Price: $686
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594518
Product name: Taccalonolide A
Packaging: 20mg
Price: $860.2
Updated: 2021/12/16

ChemScene

Product number: CS-0022618
Product name: TaccalonolideA
Packaging: 5mg
Price: $403
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb104907
Product name: Taccalonolide A
Purity: >98%,Standard References Grade
Packaging: 20mg
Price: $569.5
Updated: 2021/12/16

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Taccalonolide A Chemical Properties,Usage,Production

Uses

Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3].

Definition

ChEBI: Taccalonolide A is a withanolide.

References

[1] Tinley TL, et al. Taccalonolides E and A: Plant -derived steroids with microtubule-stabilizing activity. Cancer Res. 2003 Jun 15;63(12):3211-20. PMID:12810650
[2] Risinger AL, et al. Taccalonolides: Novel microtubule stabilizers with clinical potential. Cancer Lett. 2010 May 1;291(1):14-9. DOI:10.1016/j.canlet.2009.09.020
[3] Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8. DOI:10.1158/0008-5472.CAN-08-2037

Taccalonolide A Preparation Products And Raw materials

Raw materials

Preparation Products

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Taccalonolide A Suppliers

China 90 United States 7 Global 97

Mensura Group Limited

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Chengdu Biopurify Phytochemicals Ltd.

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EMMX Biotechnology LLC

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Shanghai ChengShao Biological Technology Co., Ltd.

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View Lastest Price from Taccalonolide A manufacturers

Career Henan Chemical Co

Product: Taccalonolide A 108885-68-3
Price: US $9.80/KG
Min. Order: 1KG
Purity: ＞98%HPLC
Supply Ability: 20 tons
Release date: 2020-02-06

108885-68-3, Taccalonolide ARelated Search:

Hydroxyecdysone (3beta,25R)-14-Hydroxyspirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-xylopyranosyl-(1-4)]-beta-D-glucopyranoside Resibufogenin ALLEOSIDE A Taccalonolide B Taccalonolide AJ Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)- poricoic acid A 3-methyl ester beta-Sitosterol Bufotaline Carabrone D-ERYTHRONOLACTONE Acetylepipodophyllotoxin KAEMPFEROL-3,7,4'-TRIMETHYL ETHER HOMOARBUTIN Podophyllotoxone clerodendrin Quillaic acid

Taccalonolide A

(1alpha,2alpha,3alpha,5alpha,7beta,11alpha,12alpha,15alpha,16beta,24beta,25S)-1,11,12,15-Tetrakis(acetyloxy)-2,3-epoxy-7,23,25-trihydroxy-6-oxo-16,24-cycloergost-22-en-26-oic acid gamma-lactone

ETaccalonolide A

Potato ketolide A

16,24-Cycloergost-22-en-26-oic acid, 1,11,12,15-tetrakis(acetyloxy)-2,3-epoxy-7,23,25-trihydroxy-6-oxo-, γ-lactone, (1α,2α,3α,5α,7β,11α,12α,15α,16β,24β,25S)-

Microtubule/Tubulin,Apoptosis,inhibit,Inhibitor,Taccalonolide A

Rhizolactone A.

Taccalonolide A, 10 mM in DMSO

108885-68-3

C36H46O14