PASIREOTIDE

ChemicalBook > CAS DataBase List > PASIREOTIDE

Product Name: PASIREOTIDE
CAS No.: 396091-73-9
Chemical Name: PASIREOTIDE
Synonyms: SOM 320;SOM 230;Signifor;PASIREOTIDE;SOM 230;SOM 320;Pasireotide (SOM-230);Pasireotide Acetate(net);CYCLO((4R)-4-(2-AMINOETHYLCARBAMOYLOXY)-L-PROLYL-L-PHENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-PHENYLALANYL-);Cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-tyrosyl-L-phenylalanyl-(4R)-4-[[[(2-aminoethyl)amino]carbonyl]oxy]-L-prolyl];[(3S,6S,9S,12R,15S,18S,20R)-9-(4-aminobutyl)-3-benzyl-12-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-phenyl-6-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] N-(2-aminoethyl)carbamate
CBNumber: CB02667889
Molecular Formula: C58H66N10O9
Formula Weight: 1047.23
MOL File: 396091-73-9.mol

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PASIREOTIDE Property

Boiling point:: 1351.4±65.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 11.86±0.46(Predicted)
Sequence: cyclo[Tyr(Bzl)-Phe-Hyp(Bom)-Phg-D-Trp-Lys]
InChIKey: VMZMNAABQBOLAK-PHODJXESNA-N
CAS DataBase Reference: 396091-73-9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H361Suspected of damaging fertility or the unborn child

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: P211010
Product name: PasireotideTFASalt
Packaging: 1mg
Price: $580
Updated: 2021/12/16

ApexBio Technology

Product number: B3596
Product name: (E)-(1Z,3S,4Z,6R,7Z,9S,10Z,12S,13Z,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13-pentahydroxy-16-oxo-3-phenyl-3,6,9,12,15,16,18,19,20,20a-decahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadeci
Packaging: 5mg
Price: $589
Updated: 2021/12/16

ApexBio Technology

Product number: B3596
Product name: (E)-(1Z,3S,4Z,6R,7Z,9S,10Z,12S,13Z,15S,19R,20aS)-6-((1H-indol-3-yl)methyl)-9-(4-aminobutyl)-15-benzyl-12-(4-(benzyloxy)benzyl)-1,4,7,10,13-pentahydroxy-16-oxo-3-phenyl-3,6,9,12,15,16,18,19,20,20a-decahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadeci
Packaging: 1mg
Price: $131
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP110151
Product name: Pasireotide acetate
Packaging: 500ug
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP110151
Product name: Pasireotide acetate
Packaging: 1mg
Price: $240
Updated: 2021/12/16

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PASIREOTIDE Chemical Properties,Usage,Production

Description

In April 2012, the European Commission approved pasireotide for the treatment of Cushing’s Disease (CD) in adult patients who have not responded to surgical interventionor forwhomsurgery is not anoption.Pasireotide was approved for the same indication by the US FDA in December of 2012. Pasireotide (also known as SOM230) is a cyclohexapeptide that acts as a somatostatin analogue to inhibit the release of ACTH. Somatostatins are cyclic peptides of 14 and 28 amino acids that play animportant role inregulating endocrineandexocrine release inmany tissues through an inhibitory mechanism. There are five known subtypes of somatostatin receptors (SSTRs). Natural somatostatins bind with high affinity to all five subtypes, however, their therapeutic use is limited by rapid degradation in plasma. Pasireotide arose fromefforts to identify a somatostatinmimetic with long-lasting inhibitory effects. Starting with a 14-amino acid somatostatin peptide, a systematic alanine scan revealed residues that were essential for receptor sub-type binding, including key b-turn regions and adjacent residues. Placing the key structural elements as unnatural amino acids in a cyclohexapeptide backbone gave pasireotide.

Originator

Novartis (Switzerland)

Uses

Pasireotide can be used in biological study of long-term treatment of Cushing''s disease with pasireotide, 5-yr results from open-label extension study of Phase III trial.

Definition

ChEBI: Pasireotide is a six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease. It has a role as an antineoplastic agent. It is a homodetic cyclic peptide and a peptide hormone. It is a conjugate base of a pasireotide(2+).

brand name

Signifor

Clinical Use

Pasireotide, also known as SOM230, is a cyclic, hexameric peptide developed by Novartis which exhibits somatostatin-like activity as an antisecretory agent used in the treatment of Cushing’s disease. Pasireotide activates a broad range of somatostatin receptors, and in particular displays a significantly higher binding affinity for somatostatin receptors 1, 3, and 5 than its competitor somatostatin-mimic octreotide in vitro, as well as a comparable binding affinity for somatostatin receptor 2. Pasireotide is more potent than somatostatin in inhibiting the secretion of human growth hormone (HGH), glucagon, and insulin.

Synthesis

The synthesis of pasireotide is relatively straightforward, given that the chemical entity is a cyclic peptide. The most likely scalable route closely mimics that described by the discovery authors involving a series of conventional couplings and deprotection steps to arrive at a linear peptide which then underwent sequential release from solid support, macrocyclization, and a global deprotection step.

Beginning from (2S,4R)-4-hydroxyproline methyl ester (110) in the scheme above, this pyrrolidine nitrogen was first Fmoc-protected in 85% yield followed by treatment with trisphosgene and N-Boc diaminoethane to provide the prolino carbamate shown in 49% yield over the two step sequence after a recrystallization with ethyl acetate.
Next, commercially available Fmoc-Tyr(Bzl)-O-CH2-Ph(3-OCH3)-O-CH2-SASRIN157 resin (112) was used as starting material in a manually operated reactor and carried through a standard protocol consisting of repetitive cycles of N|á deprotection (piperidine/DMF, 2:8), repeated washings with DMF, and coupling using DIC/HOBT in DMF (Schemes 2 and 3). The following amino acid derivatives were sequentially coupled: Fmoc-Lys(Boc)-OH, Fmoc-D-Trp(Boc)-OH, Fmoc-PhG-OH, proline derivative 111 above, and finally Fmoc-Phe-OH. Couplings were continued or repeated until complete disappearance of residual amino groups as monitored with a ninhydrin stain test. Before cleavage of the protected linear peptide from its resin support, the Fmoc group was removed. After washings with dichloromethane, the peptide resin was transferred into a column and the peptide fragment was cleaved from solid support upon subjection to 2% TFA in dichloromethane. The eluate was immediately neutralized with a saturated NaHCO3 solution which resulted in the side chain protected fragment 119 (the Scheme) was obtained in 93% homogeneity and cyclized without further purification. For cyclization, the linear fragment was dissolved in DMF, treated with DIPEA, and then 1.5 equiv of diphenylphosphoryl azide which resulted in the protected cyclized product obtained in good yield. For complete deprotection, the residue was dissolved at 0 ??C in aqueous TFA, and the mixture was stirred at this temperature for 30 min. The product was then precipitated with ether containing ca. 10 equiv of HCl, then filtered and washed with ether, and finally dried. The entire sequence produced pasireotide (XVIII) in 20% yield from resin-bound 112.

Drug interactions

Potentially hazardous interactions with other drugs
Antifungals: avoid with ketoconazole.
Ciclosporin: possibly reduces ciclosporin concentration.

Metabolism

Pasireotide is metabolically highly stable and in vitro data show that pasireotide is not a substrate, inhibitor or inducer of any major enzymes of CYP450. In healthy volunteers, pasireotide is mainly found in the unchanged form in plasma, urine and faeces.
Pasireotide is eliminated mainly by hepatic clearance and is mostly found, unchanged, in the faeces (48%) and urine.

PASIREOTIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PASIREOTIDE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pasireotide 396091-73-9
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

Shandong Huizhihan Supply Chain Co., Ltd

Product: Pasireotide 396091-73-9
Price: US $0.00-0.00/BOX
Min. Order: 1BOX
Purity: 99%
Supply Ability: 20Ton
Release date: 2024-10-30

Shandong Huizhihan Supply Chain Co., Ltd

Product: Pasireotide 396091-73-9
Price: US $0.00-0.00/BOX
Min. Order: 1BOX
Purity: 99%
Supply Ability: 20T
Release date: 2024-11-12

396091-73-9, PASIREOTIDERelated Search:

H-GLY-PRO-HYP-OH Exenatide acetate Validamine Octreotide acetate Palmitoyl Dipeptide-7 Epitalon Oxytocin Lixisenatide Somatostatin Capecitabine Liraglutide Entacapone Sincalide Abaloparatide Ganirelix Acetate Thyrotropin-releasing hormone VAPREOTIDE Etelcalcetide

PASIREOTIDE

Cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-tyrosyl-L-phenylalanyl-(4R)-4-[[[(2-aminoethyl)amino]carbonyl]oxy]-L-prolyl]

SOM 230

SOM 320

[(3S,6S,9S,12R,15S,18S,20R)-9-(4-aminobutyl)-3-benzyl-12-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-phenyl-6-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] N-(2-aminoethyl)carbamate

SOM 230;SOM 320

CYCLO((4R)-4-(2-AMINOETHYLCARBAMOYLOXY)-L-PROLYL-L-PHENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-PHENYLALANYL-)

Pasireotide Acetate(net)

Pasireotide (SOM-230)

Signifor

396091-73-9

C58H66N10O9