Cabotegravir (GSK744, GSK1265744)

Product Name: Cabotegravir (GSK744, GSK1265744)
CAS No.: 1051375-10-0
Chemical Name: Cabotegravir (GSK744, GSK1265744)
Synonyms: Cabotegravir;GSK1265744;GSK744;CS-2197;Caboteve;Cabot wei;SureCN82803;S/GSK1265744;Cabotegravin;SK744, GSK1265744
CBNumber: CB02668664
Molecular Formula: C19H17F2N3O5
Formula Weight: 405.35
MOL File: 1051375-10-0.mol

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Cabotegravir (GSK744, GSK1265744) Property

Boiling point:: 664.0±55.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥19.35 mg/mL in DMSO with gentle warming
form: solid
pka: 4.50±1.00(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27215
Product name: GSK744
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27215
Product name: GSK744
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 27215
Product name: GSK744
Packaging: 25mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 27215
Product name: GSK744
Packaging: 50mg
Price: $243
Updated: 2024/03/01

TRC

Product number: C050100
Product name: Cabotegravir
Packaging: 100mg
Price: $910
Updated: 2021/12/16

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Cabotegravir (GSK744, GSK1265744) Chemical Properties,Usage,Production

Uses

Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.

Definition

ChEBI: Cabotegravir is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It is a difluorobenzene, a secondary carboxamide, a monocarboxylic acid amide and an organic heterotricyclic compound. It is a conjugate acid of a cabotegravir(1-).

Biological Activity

Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, inhibiting HIV-1 integrase-catalyzed strand transfer with IC50 of 3 nM. Phase 2.

Mechanism of action

Caboggravir is a potent inhibitor of HIV integrase, which prevents the HIV virus from infecting human cells, while rilpivirine prevents the virus from replicating itself.

target

HIV integrase

Cabotegravir (GSK744, GSK1265744) Preparation Products And Raw materials

Raw materials

Preparation Products

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Cabotegravir (GSK744, GSK1265744) Suppliers

China 129 France 1 India 6 United Kingdom 1 United States 13 Global 150

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 8140
Advantage: 58

Jiangxi Puxin Biotechnology Co., Ltd

Tel: 15867635987 15867635987
Email: jasonhu09@163.com
Country: China
ProdList: 285
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
Advantage: 52

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Shenzhen HwaGen Pharmaceutical Co.,Ltd

Tel: 18927339850
Fax: 0752-5319394
Email: xiaodong.shi@rafflespt.com
Country: China
ProdList: 237
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-18601685-898 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2769
Advantage: 60

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View Lastest Price from Cabotegravir (GSK744, GSK1265744) manufacturers

Guangzhou Tengyue Chemical Co., Ltd.

Product: Cabotegravir (GSK744, GSK1265744) 1051375-10-0
Price: US $240.00/g
Min. Order: 10g
Purity: 99% Purity (What/sapp: +86 18145728414)
Supply Ability: 1000 Tons/Month
Release date: 2023-11-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: SureCN82803 1051375-10-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Longyan Tianhua Biological Technology Co., Ltd

Product: Cabotegravir 1051375-10-0
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2020-11-11

1051375-10-0, Cabotegravir (GSK744, GSK1265744)Related Search:

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GSK1265744

GSK744

(3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide

Cabotegravir (GSK744, GSK1265744)

Cabotegravir Free Acid

Cabotegravir

Cyclic pyranopterin

SK744, GSK1265744

Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)-

S/GSK1265744

(3S,11AR)-N-(2,4-DIFLUOROBENZYL)-6-HYDROXY-3-METHYL-5,7-DIOXO-2,3,5,7,11,11A-HEXAHYDROOXAZOLO[3,2-A]PYRIDO[1,2-D]PYRAZINE-8-CARBOXAMIDE

Cabotegravir(GSK1265744A,GSK-744)

Cabotegravir (GSK-1265744）

CS-2197

SureCN82803

GSK744 (S/GSK1265744)

Cabotegravir ,GSK744

Cabotegravir (GSK744, GSK1265744) USP/EP/BP

(3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexa...

Cabotegravir 13CD5

Cabot wei

Cabotegravir GSK744 GSK1265744 GSK-744

Cabotegravin

Caboteve

(3R,6S)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-6-methyl-8,11-dioxo-4-oxa-1,7-diazatricyclo[7.4.0.03,7]trideca-9,12-diene-12-carboxamide

1051375-10-0

C19H17F2N3O5

Inhibitors