3-Chloro-4-fluorobenzoic acid
- Product Name
- 3-Chloro-4-fluorobenzoic acid
- CAS No.
- 403-16-7
- Chemical Name
- 3-Chloro-4-fluorobenzoic acid
- Synonyms
- RARECHEM AL BO 0274;TIMTEC-BB SBB003796;1-chloro-3-fluorobezene;4-FLUORO-3-CHLOROBENZOIC ACID;3-CHLORO-4-FLUOROBENZOIC ACID;3-chloro-4-fluorobenzioc acid;3-Chloro-4-fluorobenzoicacid98%;Benzoic acid, 3-chloro-4-fluoro-;3-Chloro-4-fluorobenzoic Acid >3-Chloro-4-fluorobenzoic acid 98%
- CBNumber
- CB0267762
- Molecular Formula
- C7H4ClFO2
- Formula Weight
- 174.56
- MOL File
- 403-16-7.mol
3-Chloro-4-fluorobenzoic acid Property
- Melting point:
- 133-135 °C(lit.)
- Boiling point:
- 92°C/22mm
- Density
- 1.4016 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 3.77±0.10(Predicted)
- color
- White to Light yellow to Light orange
- BRN
- 2574799
- InChI
- InChI=1S/C7H4ClFO2/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3H,(H,10,11)
- InChIKey
- PKTSBFXIHLYGEY-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(F)C(Cl)=C1
- CAS DataBase Reference
- 403-16-7(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 3-chloro-4-fluoro- (403-16-7)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 37/39-26-36-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C1275
- Product name
- 3-Chloro-4-fluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- C1275
- Product name
- 3-Chloro-4-fluorobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $105
- Updated
- 2025/07/31
- Product number
- C584758
- Product name
- 3-Chloro-4-fluorobenzoic Acid
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C584758
- Product name
- 3-Chloro-4-fluorobenzoic Acid
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 2621-7-02
- Product name
- 3-Chloro-4-fluorobenzoic acid
- Purity
- 98%
- Packaging
- 100g
- Price
- $80
- Updated
- 2021/12/16
3-Chloro-4-fluorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Chloro-4-fluorobenzoic Acid is a useful research chemical compound used as a reactant in the structure-activity relationship study on substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists.
Synthesis
65055-17-6
403-16-7
General procedure for the synthesis of 3-chloro-4-fluorobenzoic acid from 3-chloro-4-fluorobenzoyl chloride: 2 g of 3-chloro-4-fluorobenzoyl chloride (99.6% purity, GC [a/a]) was mixed with 4 g of 50% sodium hydroxide solution and 20 g of water, and the reaction was carried out at 60 °C with cautious hydrolysis. After completion of the reaction, the reaction solution was continued to be stirred at room temperature for 2 hours. Subsequently, the reaction mixture was acidified with concentrated hydrochloric acid to pH 1. The precipitated 3-chloro-4-fluorobenzoic acid was washed sequentially with dilute hydrochloric acid and water and then dried. 1.68 g of white powdery 3-chloro-4-fluorobenzoic acid was finally obtained in 92.8% yield of the theoretical value. Melting point of the product: 136 °C (literature value: 136 °C).
References
[1] Patent: US6187952, 2001, B1
3-Chloro-4-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-4-fluorobenzoic acid Suppliers
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View Lastest Price from 3-Chloro-4-fluorobenzoic acid manufacturers
- Product
- 3-Chloro-4-fluorobenzoic acid 403-16-7
- Price
- US $80.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2019-12-24
- Product
- 3-Chloro-4-fluorobenzoic acid 403-16-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 3-Chloro-4-fluorobenzoic acid 403-16-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09