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10-Nitrocamptothecin

Product Name
10-Nitrocamptothecin
CAS No.
86639-62-5
Chemical Name
10-Nitrocamptothecin
Synonyms
RUBETICAN;9-NITRO-CPT;9-Nitro-20(S)-camptothecine;CAMPTOTHECIN, 9-NITRO-20(S)-;10-Nitrocamptothecin ISO 9001：2015 REACH;4α-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di;(S)-4-Ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-9-nitro-, (4S)-
CBNumber
CB0270140
Molecular Formula
C20H15N3O6
Formula Weight
393.35
MOL File
86639-62-5.mol
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10-Nitrocamptothecin Property

Boiling point:
827.4±65.0 °C(Predicted)
Density 
1.63±0.1 g/cm3(Predicted)
pka
11.17±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific
Product number
099302
Product name
(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
Matrix Scientific
Product number
099302
Product name
(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
AK Scientific
Product number
9741AF
Product name
(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Packaging
1g
Price
$2273
Updated
2021/12/16
Crysdot
Product number
CD32000239
Product name
9-Nitrocamptothecin
Purity
95+%
Packaging
25mg
Price
$170
Updated
2021/12/16
DC Chemicals
Product number
DCX-058
Product name
9-Nitrocamptothecin
Purity
>98%,StandardReferencesGrade
Packaging
20mg
Price
$280
Updated
2021/12/16
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10-Nitrocamptothecin Chemical Properties,Usage,Production

Uses

Whether cells can divide depends on the two key points of entering S phase and M phase. Studies have found that 10-Nitrocamptothecin can induce apoptosis. After administration, both S phase and G2M phase of cell growth are delayed. Inhibition occurred throughout the cell cycle and was found to be dose- and time-dependent.

Definition

ChEBI: Rubitecan is a pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin. It has a role as an antineoplastic agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and a prodrug. It is a pyranoindolizinoquinoline, a C-nitro compound, a semisynthetic derivative, a tertiary alcohol and a delta-lactone.

10-Nitrocamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 10-Nitrocamptothecin manufacturers

Career Henan Chemical Co
Product
9-Nitrocamptothecin 86639-62-5
Price
US $0.10/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1kg; 50kg; 500kg
Release date
2019-12-24

86639-62-5, 10-NitrocamptothecinRelated Search:

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  • RUBETICAN
  • CAMPTOTHECIN, 9-NITRO-20(S)-
  • 9-NITRO-CPT
  • 4α-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 9-Nitro-20(S)-camptothecine
  • (S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (S)-4-Ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-9-nitro-, (4S)-
  • 10-Nitrocamptothecin ISO 9001：2015 REACH
  • 86639-62-5
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