3-BroMo-2-Methylpyridine-6-carboxylic acid
- Product Name
- 3-BroMo-2-Methylpyridine-6-carboxylic acid
- CAS No.
- 137778-20-2
- Chemical Name
- 3-BroMo-2-Methylpyridine-6-carboxylic acid
- Synonyms
- 3-bromo-2-methyl-6-pyridinecarboxylic acid;3-BroMo-2-Methylpyridine-6-carboxylic acid;5-Bromo-6-methyl-pyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 5-bromo-6-methyl-
- CBNumber
- CB02715571
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 137778-20-2.mol
3-BroMo-2-Methylpyridine-6-carboxylic acid Property
- Boiling point:
- 313.7±42.0 °C(Predicted)
- Density
- 1.692±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.48±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H6BrNO2/c1-4-5(8)2-3-6(9-4)7(10)11/h2-3H,1H3,(H,10,11)
- InChIKey
- UXKSXZKZOWOMKC-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC(C)=C(Br)C=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B808138
- Product name
- 5-Bromo-6-methylpicolinicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B808138
- Product name
- 5-Bromo-6-methylpicolinicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Z0162
- Product name
- 3-Bromo-2-methylpyridine-6-carboxylicacid
- Packaging
- 5g
- Price
- $516
- Updated
- 2021/12/16
- Product number
- 120043
- Product name
- 5-Bromo-6-methylpicolinic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $810
- Updated
- 2021/12/16
- Product number
- 4H58-9-3H
- Product name
- 5-Bromo-6-methylpyridine-2-carboxylic acid
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
3-BroMo-2-Methylpyridine-6-carboxylic acid Chemical Properties,Usage,Production
Synthesis
1173897-86-3
137778-20-2
The general procedure for the synthesis of 5-bromo-6-methylpyridine-2-carboxylic acid from 5-bromo-6-methyl-2-cyanopyridine is as follows: 1. 5-bromo-6-methyl-2-cyanopyridine (18 kg, 91.37 mol), sodium hydroxide (10 kg, 250 mol), water (26 kg) and methanol (59 kg) were added sequentially in a stainless steel reactor. 2. the mixture was stirred and heated to reflux temperature (66 °C) and the reaction was kept for 1.52 hours. 3. the progress of the reaction was monitored by high performance liquid chromatography (HPLC) and the reaction was stopped when the amount of raw material remaining was less than 1%. 4. the solvent was removed by distillation under reduced pressure at a temperature below 50 °C. The solvent was then concentrated into the residue. 5. after thickening, water (72 kg) was added to the residue and the mixture was cooled to 0 °C. the reaction was stopped when the remaining amount of the feedstock was less than 1%. 6. The pH is adjusted to 7 by slow addition of sulfuric acid (105 kg) to induce precipitation of the product. 7. The precipitate was separated by centrifugation and washed with an appropriate amount of water. 8. The resulting solid was dried in a vacuum drying oven to give the white solid product 5-bromo-6-methylpyridine-2-carboxylic acid (17.8 kg, 82.3 mol). The purity of the product was greater than 98% and the yield was 90%.
References
[1] Patent: US2010/305330, 2010, A1. Location in patent: Page/Page column 3
3-BroMo-2-Methylpyridine-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BroMo-2-Methylpyridine-6-carboxylic acid manufacturers
- Product
- 5-Bromo-6-methylpicolinic acid 137778-20-2
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 3-BroMo-2-Methylpyridine-6-carboxylic acid 137778-20-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 97%
- Supply Ability
- >10kg
- Release date
- 2021-07-09