5-Bromo-2-methoxy-4-methyl-3-nitropyridine

Product Name: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine
CAS No.: 884495-14-1
Chemical Name: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine
Synonyms: SKL432;5-Bromo-2-methoxy-3-nitro-4-picoline;5-BroMo-2-Methoxy-4-Methyl-3-nitropyridin;5-Bromo-2-methoxy-4-methy1-3-aitropyridine;2-Methoxy-3-nitro-4-methyl-5-Bromopyridine;2-METHOXY-3-NITRO-5-BROMO-4-METHYLPYRIDINE;5-Bromo-2-methoxy-4-methyl-3-nitropyridine;5-Bromo-2-methoxy-4-methyl-3-nitropyridine-3;Pyridine, 5-broMo-2-Methoxy-4-Methyl-3-nitro-;5-Bromo-2-methoxy-4-methyl-3-nitropyridine≥ 99% (HPLC)
CBNumber: CB11012650
Molecular Formula: C7H7BrN2O3
Formula Weight: 247.05
MOL File: 884495-14-1.mol

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5-Bromo-2-methoxy-4-methyl-3-nitropyridine Property

Boiling point:: 302.8±37.0 °C(Predicted)
Density: 1.636±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, Dichloromethane, Ethyl Acetate
pka: -2.34±0.28(Predicted)
form: Solid
color: Light Yellow
InChI: InChI=1S/C7H7BrN2O3/c1-4-5(8)3-9-7(13-2)6(4)10(11)12/h3H,1-2H3
InChIKey: BGDKJBCVNNWITN-UHFFFAOYSA-N
SMILES: C1(OC)=NC=C(Br)C(C)=C1[N+]([O-])=O

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B684810
Product name: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine
Packaging: 1g
Price: $60
Updated: 2021/12/16

TRC

Product number: B684810
Product name: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine
Packaging: 5g
Price: $220
Updated: 2021/12/16

TRC

Product number: B684810
Product name: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine
Packaging: 10g
Price: $415
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19094
Product name: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine
Packaging: 50g
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0366877
Product name: 5-BROMO-2-METHOXY-4-METHYL-3-NITROPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $502.03
Updated: 2021/12/16

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5-Bromo-2-methoxy-4-methyl-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

5-Bromo-2-methoxy-4-methyl-3-nitropyridine (BMN) is a chemical compound with anticancer activity. BMN inhibits tumor growth by binding to the bromodomain, which is found in many proteins that regulate cell division and DNA repair.

Synthesis

160590-36-3

884495-14-1

The general procedure for the synthesis of 5-bromo-2-methoxy-4-methyl-3-nitropyridine using 2-methoxy-3-nitro-4-methylpyridine as starting material was as follows: sodium acetate (365 g, 5.37 mol) was slowly added to a stirring solution of 2-methoxy-4-methyl-3-nitropyridine (250 g, 1.49 mol) in acetic acid (1.5 L) at room temperature. Subsequently, bromine (Br2, 639 g, 4.00 mol) was added dropwise and the dropwise addition time was controlled to be less than 30 minutes. After addition, the reaction mixture was warmed up to 80 °C for 12 h, during which the progress of the reaction was monitored by thin-layer chromatography (TLC) to confirm that the reaction was complete. Upon completion of the reaction, the mixture was cooled to 0 °C and 10% aqueous solution (1.5 L) and saturated aqueous sodium sulfate solution (1.5 L) were added sequentially to quench the reaction. The resulting solid product was collected by filtration, washed with water, and then dried under reduced pressure to finally obtain 5-bromo-2-methoxy-4-methyl-3-nitropyridine (302 g, 82.2% yield) as a light yellow solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.25 (s, 1H), 3.94 (s, 3H), 2.29 (s, 3H).

References

[1] Patent: WO2016/77378, 2016, A1. Location in patent: Page/Page column 85; 86; 157; 158; 163; 164
[2] Patent: WO2016/77380, 2016, A1. Location in patent: Page/Page column 63; 64
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5391 - 5402
[4] Patent: WO2016/77375, 2016, A1. Location in patent: Page/Page column 79-80
[5] Patent: WO2016/123391, 2016, A1. Location in patent: Page/Page column 76; 77; 185; 186

5-Bromo-2-methoxy-4-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-methoxy-4-methyl-3-nitropyridine Suppliers

Canada 1 China 183 India 9 United Kingdom 2 United States 12 Global 207

Shanghai Pullins Pharmaceutical Technology Co., LTD

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View Lastest Price from 5-Bromo-2-methoxy-4-methyl-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine 884495-14-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-06

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine 884495-14-1
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1g
Purity: 98%
Supply Ability: 50tons
Release date: 2020-05-12

Henan Fengda Chemical Co., Ltd

Product: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine 884495-14-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

884495-14-1, 5-Bromo-2-methoxy-4-methyl-3-nitropyridineRelated Search:

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5-Bromo-2-methoxy-4-methyl-3-nitropyridine

5-Bromo-2-methoxy-3-nitro-4-picoline

5-BroMo-2-Methoxy-4-Methyl-3-nitropyridin

5-Bromo-2-methoxy-4-methyl-3-nitropyridine-3

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2-METHOXY-3-NITRO-5-BROMO-4-METHYLPYRIDINE

5-Bromo-2-methoxy-4-methyl-3-nitropyridine≥ 99% (HPLC)

2-Methoxy-3-nitro-4-methyl-5-Bromopyridine

5-Bromo-2-methoxy-4-methyl-3-nitropyridine ISO 9001：2015 REACH

SKL432

5-Bromo-2-methoxy-4-methy1-3-aitropyridine

884495-14-1

C7H7BrN2O3

Pyridine Series

Aromatics

Heterocycles

CHIRAL CHEMICALS