SAR407899

Product Name: SAR407899
CAS No.: 923359-38-0
Chemical Name: SAR407899
Synonyms: SAR407899 free base;SAR407899, 10 mM in DMSO;6-(piperidin-4-yloxy)isoquinolin-1(2H)-one;1(2H)-Isoquinolinone, 6-(4-piperidinyloxy)-;-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one;SAR 407899,Rho-associated kinase,ROK,Rho-kinase,ROCK,Rho-associated protein kinase,SAR407899,inhibit,SAR-407899,Inhibitor
CBNumber: CB02735537
Molecular Formula: C14H16N2O2
Formula Weight: 244.29
MOL File: 923359-38-0.mol

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SAR407899 Property

Boiling point:: 517.8±50.0 °C(Predicted)
Density: 1.193±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 6 mg/mL (24.56 mM; Need warming)
form: Powder
pka: 12.79±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21717
Product name: SAR407899
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21717
Product name: SAR407899
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 21717
Product name: SAR407899
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 21717
Product name: SAR407899
Purity: ≥98%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

ChemScene

Product number: CS-3570
Product name: SAR407899
Purity: 99.97%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

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SAR407899 Chemical Properties,Usage,Production

Uses

SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. SAR407899 shows stable inhibition of migrasome formation.

in vivo

SAR407899 (3 mg/kg, i.v.) inhibits ROCK-mediated phosphorylation of MYPT^T696 in thoracic aorta of spontaneously hypertensive rats (SHRs). SAR407899 (0.01-0.30 mg/kg, i.v.) efficiently reduces pressor responses to vasoconstrictor agents in rats. SAR407899 (1, 3, 10, and 30 mg/kg, p.o.) dose dependently lowers blood pressure in hypertensive SHRs^[1]. SAR407899 (1-3 mg/kg, i.v. or 3, 10 mg/kg, p.o.) increases the length of the penis in healthy rabbits. SAR407899 (3-10 mg/kg, p.o.) also dose-dependently increases penile length in diabetic rabbits^[2].

IC 50

ROCK-2: 102 nM (IC₅₀); ROCK-1: 276 nM (IC₅₀)

References

[1] L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83. DOI:10.1161/HYPERTENSIONAHA.109.134353
[2] Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59. DOI:10.1186/1479-5876-10-59
[3] Puzhong Lu, et al. Chemical screening identifies ROCK1 as a regulator of migrasome formation. Cell Discov. 2020 Aug 4;6(1):51. DOI:10.1038/s41421-020-0179-6

SAR407899 Preparation Products And Raw materials

Raw materials

Preparation Products

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SAR407899 Suppliers

China 54 India 1 United States 7 Global 62

Haoyuan Chemexpress Co., Ltd.

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923359-38-0, SAR407899Related Search:

SAR 131675 SAR-020106 SAR245409 SAR-20347 SAR125844

6-(piperidin-4-yloxy)isoquinolin-1(2H)-one

-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one

SAR407899 free base

1(2H)-Isoquinolinone, 6-(4-piperidinyloxy)-

SAR 407899,Rho-associated kinase,ROK,Rho-kinase,ROCK,Rho-associated protein kinase,SAR407899,inhibit,SAR-407899,Inhibitor

SAR407899, 10 mM in DMSO

923359-38-0