SAR125844

Product Name: SAR125844
CAS No.: 1116743-46-4
Chemical Name: SAR125844
Synonyms: SAR125884;SAR125844;SAR125844 /SAR-125844;SAR125844; SAR 125844; SAR-125844;SAR125884 hydrochlorid (1116743-46-4(free base));Inhibitor,SAR125844,c-Met/HGFR,inhibit,SAR 125844,SAR-125844,Apoptosis;1-(6-((6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea;Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-;1-[6-[[6-(4-Fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-[2-(morpholin-4-yl)ethyl]urea
CBNumber: CB22668390
Molecular Formula: C25H23FN8O2S2
Formula Weight: 550.63
MOL File: 1116743-46-4.mol

More

Less

SAR125844 Property

storage temp.: Store at -20°C
solubility: DMSO : 45 mg/mL (81.72 mM)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0006341
Product name: SAR125844
Purity: 99.03%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0006341
Product name: SAR125844
Purity: 99.03%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0006341
Product name: SAR125844
Purity: 99.03%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573075
Product name: SAR125844
Purity: >98%
Packaging: 100mg
Price: $1208.7
Updated: 2021/12/16

ChemScene

Product number: CS-0006341
Product name: SAR125844
Purity: 99.03%
Packaging: 100mg
Price: $1300
Updated: 2021/12/16

More

Less

SAR125844 Chemical Properties,Usage,Production

Biological Activity

SAR125844 is a potent and highly selective Met (c-Met) kinase inhibitor with nanomolar activity against wild-type Met (c-Met) kinase (IC50=4.2 nM), against H1094Y, Y1235D, M1250T, The IC50s of the L1195V and D1228H mutants were 0.22, 1.7, 6.5, 65 and 81 nM, respectively.

in vitro

SAR125844 is an ATP-competitive and reversible inhibitor. SAR125844 has moderate activity against RON, a homolog that is structurally similar to MET, and SAR125844 inhibits RON with an IC50 of approximately 740 nM. SAR125844 is more than 100-fold more selective for MET kinase than for RON.

in vivo

In a pharmacokinetic study in mice, the oral bioavailability of SAR125844 was low, approximately 2%. Its Caco-2 permeability is moderate. In female SCID mice bearing xenograft tumors (inoculated with the MET-expanded Hs 746T human gastric tumor cell line), a single intravenous injection of 20 mg/kg of SAR125844 resulted in a plasma exposure of 6190 h ng/kg mL, clearance CL = 3.1 L/h/kg, large volume of distribution (Vss = 4.2 L/kg).

SAR125844 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

SAR125844 Suppliers

China 36 India 1 United States 3 Global 40

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7892
Advantage: 56

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9756
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Shanghai Medicil Biomedical Co., Ltd.

Tel: 021-50822001
Email: marketing@medicilon.com.cn
Country: China
ProdList: 1152
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 2881290884@qq.com
Country: China
ProdList: 7502
Advantage: 58

More

Less

View Lastest Price from SAR125844 manufacturers

Career Henan Chemical Co

Product: SAR125844 1116743-46-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

1116743-46-4, SAR125844Related Search:

SAR 131675 SAR-020106 SAR245409 SAR-20347 SAR407899

SAR125884

SAR125884 hydrochlorid (1116743-46-4(free base))

SAR125844; SAR 125844; SAR-125844

SAR125844

1-[6-[[6-(4-Fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-[2-(morpholin-4-yl)ethyl]urea

SAR125844 /SAR-125844

Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-

1-(6-((6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea

Inhibitor,SAR125844,c-Met/HGFR,inhibit,SAR 125844,SAR-125844,Apoptosis

1116743-46-4

C25H23FN8O2S2