SAR-20347
- Product Name
- SAR-20347
- CAS No.
- 1450881-55-6
- Chemical Name
- SAR-20347
- Synonyms
- CS-2527;CPDD1211;SAR-20347;SAR-20347;SAR 20347;SAR20347;inhibit,SAR 20347,Janus kinase,JAK,SAR-20347,Inhibitor;2-(2-chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide;4-Oxazolecarboxamide, 2-(2-chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-;2-(2-chloro-6-fluorophenyl)-5-({4-[(morpholin-4-yl)carbonyl]phenyl}amino)-1,3-oxazole-4-carboxylic acid amide
- CBNumber
- CB23052811
- Molecular Formula
- C21H18ClFN4O4
- Formula Weight
- 444.84
- MOL File
- 1450881-55-6.mol
SAR-20347 Property
- Boiling point:
- 698.3±65.0 °C(Predicted)
- Density
- 1.445±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:94.5(Max Conc. mg/mL);212.43(Max Conc. mM)
- form
- A solid
- pka
- 13.97±0.50(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- SML2915
- Product name
- SAR-20347
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2024/03/01
- Product number
- SML2915
- Product name
- SAR-20347
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $418
- Updated
- 2024/03/01
- Product number
- 29248
- Product name
- SAR20347
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 29248
- Product name
- SAR20347
- Packaging
- 25mg
- Price
- $510
- Updated
- 2024/03/01
- Product number
- 29248
- Product name
- SAR20347
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
SAR-20347 Chemical Properties,Usage,Production
Uses
SAR-20347 is a small molecule inhibitor with specificity for JAK1 and tyrosine kinase 2 (TYK2).
Biochem/physiol Actions
SAR-20347 is an orally active, ATP-competitive, TYK2- and JAK1-selective tyrosine kinase inhibitor (IC50 = 13 nM/TYK2 & 59 nM/JAK1 vs. 0.88 μM/JAK2 & 1.44 μM/JAK3 with 10 μM ATP) that effectively inhibits cellular TYK2- (IL12-induced pSTAT4 IC50 = 107 nM/CD4+ cells, 126 nM/NK-92) and JAK1- (IL6-induced pSTAT3 IC50 = 345 nM/TF-1, 407 nM/CD14+ cells) mediated signaling with little affinity toward 72 other kinases. SAR-20347 suppresses IL22-induced serum amyloid A (by 44%; 50 mg/kg p.o. 30 min prior to 10 μg IL22 i.p.) and alleviates imiquimod-induced psoriasis-like dermatitis (30 min prior and 5 h post daily 62.5 mg 5% imiquimod cream) in mice in vivo.
SAR-20347 Preparation Products And Raw materials
Raw materials
Preparation Products
SAR-20347 Suppliers
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