SAR-20347
- Product Name
- SAR-20347
- CAS No.
- 1450881-55-6
- Chemical Name
- SAR-20347
- Synonyms
- CS-2527;CPDD1211;SAR-20347;SAR-20347 ，S0437;SAR-20347 (SAR20347);SAR-20347, 10 mM in DMSO;SAR-20347;SAR 20347;SAR20347;inhibit,SAR 20347,Janus kinase,JAK,SAR-20347,Inhibitor;2-(2-chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide;4-Oxazolecarboxamide, 2-(2-chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-
- CBNumber
- CB23052811
- Molecular Formula
- C21H18ClFN4O4
- Formula Weight
- 444.84
- MOL File
- 1450881-55-6.mol
SAR-20347 Property
- Boiling point:
- 698.3±65.0 °C(Predicted)
- Density
- 1.445±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:94.5(Max Conc. mg/mL);212.43(Max Conc. mM)
- form
- A solid
- pka
- 13.97±0.50(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML2915
- Product name
- SAR-20347
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $87.03
- Updated
- 2025/07/31
- Product number
- SML2915
- Product name
- SAR-20347
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $366
- Updated
- 2025/07/31
- Product number
- 29248
- Product name
- SAR20347
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 29248
- Product name
- SAR20347
- Packaging
- 25mg
- Price
- $510
- Updated
- 2024/03/01
- Product number
- 29248
- Product name
- SAR20347
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
SAR-20347 Chemical Properties,Usage,Production
Uses
SAR-20347 is a small molecule inhibitor with specificity for JAK1 and tyrosine kinase 2 (TYK2).
Biochem/physiol Actions
SAR-20347 is an orally active, ATP-competitive, TYK2- and JAK1-selective tyrosine kinase inhibitor (IC50 = 13 nM/TYK2 & 59 nM/JAK1 vs. 0.88 μM/JAK2 & 1.44 μM/JAK3 with 10 μM ATP) that effectively inhibits cellular TYK2- (IL12-induced pSTAT4 IC50 = 107 nM/CD4+ cells, 126 nM/NK-92) and JAK1- (IL6-induced pSTAT3 IC50 = 345 nM/TF-1, 407 nM/CD14+ cells) mediated signaling with little affinity toward 72 other kinases. SAR-20347 suppresses IL22-induced serum amyloid A (by 44%; 50 mg/kg p.o. 30 min prior to 10 μg IL22 i.p.) and alleviates imiquimod-induced psoriasis-like dermatitis (30 min prior and 5 h post daily 62.5 mg 5% imiquimod cream) in mice in vivo.
in vivo
60 mg/kg SAR-20347 inhibits the production of IFN-γ in the serum by 91% compare to vehicle-treated animals, demonstrating that SAR-20347 can inhibit TYK2 signaling in vivo. SAR-20347 treatment significantly reduces IL-17 production as measured by average signal intensity, consistent with the gene expression analysis[1].
IC 50
Tyk2: 0.6 nM (IC50); JAK1: 23 nM (IC50); JAK2: 26 nM (IC50); JAK3: 41 nM (IC50)
SAR-20347 Preparation Products And Raw materials
Raw materials
Preparation Products
SAR-20347 Suppliers
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