ChemicalBook > CAS DataBase List > SAR-20347
SAR-20347
- Product Name
- SAR-20347
- CAS No.
- 1450881-55-6
- Chemical Name
- SAR-20347
- Synonyms
- CS-2527;CPDD1211;SAR-20347;SAR-20347;SAR 20347;SAR20347;inhibit,SAR 20347,Janus kinase,JAK,SAR-20347,Inhibitor;2-(2-chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide;4-Oxazolecarboxamide, 2-(2-chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-;2-(2-chloro-6-fluorophenyl)-5-({4-[(morpholin-4-yl)carbonyl]phenyl}amino)-1,3-oxazole-4-carboxylic acid amide
- CBNumber
- CB23052811
- Molecular Formula
- C21H18ClFN4O4
- Formula Weight
- 444.84
- MOL File
- 1450881-55-6.mol
More
Less
SAR-20347 Property
- Boiling point:
- 698.3±65.0 °C(Predicted)
- Density
- 1.445±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:94.5(Max Conc. mg/mL);212.43(Max Conc. mM)
- form
- A solid
- pka
- 13.97±0.50(Predicted)
- color
- Light yellow to yellow
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2915
- Product name
- SAR-20347
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML2915
- Product name
- SAR-20347
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $418
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29248
- Product name
- SAR20347
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29248
- Product name
- SAR20347
- Packaging
- 25mg
- Price
- $510
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29248
- Product name
- SAR20347
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
More
Less
SAR-20347 Chemical Properties,Usage,Production
Uses
SAR-20347 is a small molecule inhibitor with specificity for JAK1 and tyrosine kinase 2 (TYK2).
Biochem/physiol Actions
SAR-20347 is an orally active, ATP-competitive, TYK2- and JAK1-selective tyrosine kinase inhibitor (IC50 = 13 nM/TYK2 & 59 nM/JAK1 vs. 0.88 μM/JAK2 & 1.44 μM/JAK3 with 10 μM ATP) that effectively inhibits cellular TYK2- (IL12-induced pSTAT4 IC50 = 107 nM/CD4+ cells, 126 nM/NK-92) and JAK1- (IL6-induced pSTAT3 IC50 = 345 nM/TF-1, 407 nM/CD14+ cells) mediated signaling with little affinity toward 72 other kinases. SAR-20347 suppresses IL22-induced serum amyloid A (by 44%; 50 mg/kg p.o. 30 min prior to 10 μg IL22 i.p.) and alleviates imiquimod-induced psoriasis-like dermatitis (30 min prior and 5 h post daily 62.5 mg 5% imiquimod cream) in mice in vivo.
SAR-20347 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
SAR-20347 Suppliers
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3466
- Advantage
- 58
- Tel
- +86-2332782371 +86-18120098618
- sales@adobechem.com
- Country
- China
- ProdList
- 1250
- Advantage
- 50
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4334
- Advantage
- 55
- Tel
- 021-61350663 13052117465
- Fax
- 021-61350662
- sales@zehanbiopharma.com
- Country
- China
- ProdList
- 1003
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2990
- Advantage
- 58
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9946
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29786
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131980
- Advantage
- 58
- Tel
- 0550-5196001 15000891977
- Fax
- 0550-5196001
- wj520wjxby@126.com
- Country
- China
- ProdList
- 1841
- Advantage
- 55