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SAR-020106

Product Name
SAR-020106
CAS No.
1184843-57-9
Chemical Name
SAR-020106
Synonyms
SAR20106;SAR 20106;SAR-020106;SAR-020106 >=95%;SAR-020106, 10 mM in DMSO;SAR020106; SAR020106; SAR 020106; SAR20106; SAR20106; SAR 20106;5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile;(R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile;2-Pyrazinecarbonitrile, 5-[(8-chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-;SAR020106,cycle,SN38,selectivity,SAR-020106,SW620,cancer,inhibit,colon,cells,Checkpoint Kinase (Chk),antitumor,arrest,Inhibitor,SAR 020106
CBNumber
CB72731134
Molecular Formula
C19H19ClN6O
Formula Weight
382.85
MOL File
1184843-57-9.mol
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SAR-020106 Property

form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C585560
Product name
5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile
Packaging
2.5mg
Price
$370
Updated
2021/12/16
ChemScene
Product number
CS-0018190
Product name
SAR-020106
Purity
98.53%
Packaging
5mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0018190
Product name
SAR-020106
Purity
98.53%
Packaging
10mg
Price
$320
Updated
2021/12/16
ChemScene
Product number
CS-0018190
Product name
SAR-020106
Purity
98.53%
Packaging
25mg
Price
$600
Updated
2021/12/16
AK Scientific
Product number
SYN1189
Product name
SAR020106
Packaging
10mg
Price
$625
Updated
2021/12/16
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SAR-020106 Chemical Properties,Usage,Production

Uses

5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile is a potent and selective CHK1 inhibitor. CHK1 is a serine/threonine kinase involved with DNA damage repair and cell cycle arrest.

in vivo

SAR-020106 (40 mg/kg; i.p.; administered on days 0, 1, 7, 8, 14, and 15) in combination with Irinotecan potentiates the antitumor activity in SW620 xenografts[1].

Animal Model:Nude mice bearing SW620 xenograft tumors[1]
Dosage:40 mg/kg
Administration:I.p.; administered on days 0, 1, 7, 8, 14, and 15
Result:There was a clear decrease in tumor growth associated with the combination with tumors reaching 300% by 12.5 days.

IC 50

Chk1: 13.3 nM (IC50)

SAR-020106 Preparation Products And Raw materials

Raw materials

Preparation Products

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SAR-020106 Suppliers

China 60 United Kingdom 1 United States 3 Global 64
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Twochem Co.Ltd
Tel
021-021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
304
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Changzhou PBpharmaceutical R&D Co.,Ltd
Tel
086-0519-83990708 18915800124
Fax
0519-83990708
Email
info@pbpharm.com
Country
China
ProdList
487
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
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View Lastest Price from SAR-020106 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
SAR-020106 1184843-57-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

1184843-57-9, SAR-020106Related Search:

SAR 131675 SAR245409 SAR-20347 SAR125844 SAR407899

  • SAR-020106
  • (R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile
  • 5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile
  • SAR-020106 >=95%
  • SAR 20106
  • SAR020106; SAR020106; SAR 020106; SAR20106; SAR20106; SAR 20106
  • SAR20106
  • 2-Pyrazinecarbonitrile, 5-[(8-chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-
  • SAR020106,cycle,SN38,selectivity,SAR-020106,SW620,cancer,inhibit,colon,cells,Checkpoint Kinase (Chk),antitumor,arrest,Inhibitor,SAR 020106
  • SAR-020106, 10 mM in DMSO
  • 1184843-57-9
  • 184843-57-9
  • C19H19ClN6O
  • C19H19N6OCl