ChemicalBook > CAS DataBase List > SAR-020106

SAR-020106

Product Name
SAR-020106
CAS No.
1184843-57-9
Chemical Name
SAR-020106
Synonyms
SAR20106;SAR 20106;SAR-020106;SAR-020106 >=95%;SAR-020106, 10 mM in DMSO;SAR020106; SAR020106; SAR 020106; SAR20106; SAR20106; SAR 20106;5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile;(R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile;2-Pyrazinecarbonitrile, 5-[(8-chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-;SAR020106,cycle,SN38,selectivity,SAR-020106,SW620,cancer,inhibit,colon,cells,Checkpoint Kinase (Chk),antitumor,arrest,Inhibitor,SAR 020106
CBNumber
CB72731134
Molecular Formula
C19H19ClN6O
Formula Weight
382.85
MOL File
1184843-57-9.mol
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SAR-020106 Property

form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
C585560
Product name
5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile
Packaging
2.5mg
Price
$370
Updated
2021/12/16
ChemScene
Product number
CS-0018190
Product name
SAR-020106
Purity
98.53%
Packaging
25mg
Price
$600
Updated
2021/12/16
AK Scientific
Product number
SYN1189
Product name
SAR020106
Packaging
10mg
Price
$625
Updated
2021/12/16
ChemScene
Product number
CS-0018190
Product name
SAR-020106
Purity
98.53%
Packaging
5mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0018190
Product name
SAR-020106
Purity
98.53%
Packaging
10mg
Price
$320
Updated
2021/12/16
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SAR-020106 Chemical Properties,Usage,Production

Uses

5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile is a potent and selective CHK1 inhibitor. CHK1 is a serine/threonine kinase involved with DNA damage repair and cell cycle arrest.

in vivo

SAR-020106 (40 mg/kg; i.p.; administered on days 0, 1, 7, 8, 14, and 15) in combination with Irinotecan potentiates the antitumor activity in SW620 xenografts[1].

Animal Model:Nude mice bearing SW620 xenograft tumors[1]
Dosage:40 mg/kg
Administration:I.p.; administered on days 0, 1, 7, 8, 14, and 15
Result:There was a clear decrease in tumor growth associated with the combination with tumors reaching 300% by 12.5 days.

IC 50

Chk1: 13.3 nM (IC50)

SAR-020106 Preparation Products And Raw materials

Raw materials

Preparation Products

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SAR-020106 Suppliers

China 60 United Kingdom 1 United States 3 Global 64
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9520
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
Twochem Co.Ltd
Tel
021-021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
304
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
88915
Advantage
60
Changzhou PBpharmaceutical R&D Co.,Ltd
Tel
086-0519-83990708 18915800124
Fax
0519-83990708
Email
info@pbpharm.com
Country
China
ProdList
480
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
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View Lastest Price from SAR-020106 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
SAR-020106 1184843-57-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

1184843-57-9, SAR-020106Related Search:

SAR 131675 SAR245409 SAR-20347 SAR125844 SAR407899

  • SAR-020106
  • (R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile
  • 5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile
  • SAR-020106 >=95%
  • SAR 20106
  • SAR020106; SAR020106; SAR 020106; SAR20106; SAR20106; SAR 20106
  • SAR20106
  • 2-Pyrazinecarbonitrile, 5-[(8-chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-
  • SAR020106,cycle,SN38,selectivity,SAR-020106,SW620,cancer,inhibit,colon,cells,Checkpoint Kinase (Chk),antitumor,arrest,Inhibitor,SAR 020106
  • SAR-020106, 10 mM in DMSO
  • 1184843-57-9
  • 184843-57-9
  • C19H19ClN6O
  • C19H19N6OCl