ChemicalBook > CAS DataBase List > SAR-020106

SAR-020106

Product Name: SAR-020106
CAS No.: 1184843-57-9
Chemical Name: SAR-020106
Synonyms: SAR20106;SAR 20106;SAR-020106;SAR-020106 >=95%;SAR-020106, 10 mM in DMSO;SAR020106; SAR020106; SAR 020106; SAR20106; SAR20106; SAR 20106;5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile;(R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile;2-Pyrazinecarbonitrile, 5-[(8-chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-;SAR020106,cycle,SN38,selectivity,SAR-020106,SW620,cancer,inhibit,colon,cells,Checkpoint Kinase (Chk),antitumor,arrest,Inhibitor,SAR 020106
CBNumber: CB72731134
Molecular Formula: C19H19ClN6O
Formula Weight: 382.85
MOL File: 1184843-57-9.mol

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SAR-020106 Property

form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C585560
Product name: 5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile
Packaging: 2.5mg
Price: $370
Updated: 2021/12/16

ChemScene

Product number: CS-0018190
Product name: SAR-020106
Purity: 98.53%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0018190
Product name: SAR-020106
Purity: 98.53%
Packaging: 10mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-0018190
Product name: SAR-020106
Purity: 98.53%
Packaging: 25mg
Price: $600
Updated: 2021/12/16

AK Scientific

Product number: SYN1189
Product name: SAR020106
Packaging: 10mg
Price: $625
Updated: 2021/12/16

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SAR-020106 Chemical Properties,Usage,Production

Uses

5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile is a potent and selective CHK1 inhibitor. CHK1 is a serine/threonine kinase involved with DNA damage repair and cell cycle arrest.

in vivo

SAR-020106 (40 mg/kg; i.p.; administered on days 0, 1, 7, 8, 14, and 15) in combination with Irinotecan potentiates the antitumor activity in SW620 xenografts^[1].

Animal Model:	Nude mice bearing SW620 xenograft tumors^[1]
Dosage:	40 mg/kg
Administration:	I.p.; administered on days 0, 1, 7, 8, 14, and 15
Result:	There was a clear decrease in tumor growth associated with the combination with tumors reaching 300% by 12.5 days.

IC 50

Chk1: 13.3 nM (IC₅₀)

SAR-020106 Preparation Products And Raw materials

Raw materials

Preparation Products

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SAR-020106 Suppliers

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View Lastest Price from SAR-020106 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: SAR-020106 1184843-57-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

1184843-57-9, SAR-020106Related Search:

SAR 131675 SAR245409 SAR-20347 SAR125844 SAR407899

SAR-020106

(R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile

5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile

SAR-020106 >=95%

SAR 20106

SAR020106; SAR020106; SAR 020106; SAR20106; SAR20106; SAR 20106

SAR20106

2-Pyrazinecarbonitrile, 5-[(8-chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-

SAR020106,cycle,SN38,selectivity,SAR-020106,SW620,cancer,inhibit,colon,cells,Checkpoint Kinase (Chk),antitumor,arrest,Inhibitor,SAR 020106

SAR-020106, 10 mM in DMSO

1184843-57-9

184843-57-9

C19H19ClN6O

C19H19N6OCl