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SAR 131675

Product Name
SAR 131675
CAS No.
1433953-83-3
Chemical Name
SAR 131675
Synonyms
CS-994;SAR 131675 USP/EP/BP;(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;(R)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo-
CBNumber
CB92666683
Molecular Formula
C18H22N4O4
Formula Weight
358.39
MOL File
1433953-83-3.mol
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SAR 131675 Property

Boiling point:
592.2±50.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
insoluble in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
12.20±0.29(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28385
Product name
SAR131675
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28385
Product name
SAR131675
Packaging
25mg
Price
$343
Updated
2024/03/01
Cayman Chemical
Product number
28385
Product name
SAR131675
Packaging
5mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
28385
Product name
SAR131675
Packaging
10mg
Price
$169
Updated
2024/03/01
Activate Scientific
Product number
AS10294
Product name
SAR131675
Purity
90+% ee
Packaging
25mg
Price
$170
Updated
2021/12/16
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SAR 131675 Chemical Properties,Usage,Production

Characteristics

SAR131675 is a potent and selective VEGFR-3 tyrosine kinase inhibitor

Biological Activity

sar131675 is a selective inhibitor of vegfr-3 with ic50 value of 20nm [1].sar131675 is an atp-competitive inhibitor. it inhibits recombinant human vegfr-3 with ic50 value of 23nm and inhibits the kinase activity of vegfr-3 with ki value of 12nm. sar131675 is found to be cell permeable and inhibits vegfr-3 autophosphorylation in hek cells with ic50 values ranging from 30nm to 50nm. sar131675 shows ic50 values of >3μm and 235nm against vegfr-1 and vegfr-2, respectively. it also havs no inhibitory effect on a panel of 65 kinases, 107 nonkinase enzymes and receptors and on 21 ion channels. moreover, sar131675 inhibits lymphatic cell survival induced by vegfc and vegfd with ic50 values of 14nm and 17nm. on another hand, sar131675 exerts inhibition of the migration induced by vegfa or vegfc with ic50 values of 100nm and <30nm in hlmvec cells, respectively [1]..

in vitro

SAR131675 inhibits the proliferation of primary human lymph node cells induced by VEGFR-3 ligands VEGFC and VEGFD in a dose-dependent manner with IC50 of approximately 20 nM, and also inhibits the activity of rh-VEGFR-3–TK in a dose-dependent manner characteristic, IC50 of 23 nM. SAR131675 inhibits VEGFR-1–TK activity with IC50 greater than 3 μM and inhibits VEGFR-2–TK activity with IC50 of 235 nM.

in vivo

sar131675 abrogates lymphangiogenesis and angiogenesis induced by fgf2. it also shows antitumor activity in the mice models. treatment with sar131675 significantly reduces the tumor volume of 4t1 mammary carcinoma tumors [1]

target

VEGFR3

References

[1] alam a, blanc i, gueguen-dorbes g, et al. sar131675, a potent and selective vegfr-3–tk inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. molecular cancer therapeutics, 2012, 11(8): 1637-1649.

SAR 131675 Preparation Products And Raw materials

Raw materials

Preparation Products

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SAR 131675 Suppliers

Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9204
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
Advantage
50
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58

1433953-83-3, SAR 131675Related Search:


  • CS-994
  • (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
  • 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo-
  • SAR 131675 USP/EP/BP
  • (R)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
  • 1433953-83-3
  • Inhibitors
  • API