SAR-20347

ChemicalBook > CAS DataBase List > SAR-20347

Product Name: SAR-20347
CAS No.: 1450881-55-6
Chemical Name: SAR-20347
Synonyms: CS-2527;CPDD1211;SAR-20347;SAR-20347;SAR 20347;SAR20347;inhibit,SAR 20347,Janus kinase,JAK,SAR-20347,Inhibitor;2-(2-chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide;4-Oxazolecarboxamide, 2-(2-chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-;2-(2-chloro-6-fluorophenyl)-5-({4-[(morpholin-4-yl)carbonyl]phenyl}amino)-1,3-oxazole-4-carboxylic acid amide
CBNumber: CB23052811
Molecular Formula: C21H18ClFN4O4
Formula Weight: 444.84
MOL File: 1450881-55-6.mol

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SAR-20347 Property

Boiling point:: 698.3±65.0 °C(Predicted)
Density: 1.445±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:94.5(Max Conc. mg/mL);212.43(Max Conc. mM)
form: A solid
pka: 13.97±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2915
Product name: SAR-20347
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2915
Product name: SAR-20347
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $418
Updated: 2024/03/01

Cayman Chemical

Product number: 29248
Product name: SAR20347
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 29248
Product name: SAR20347
Packaging: 25mg
Price: $510
Updated: 2024/03/01

Cayman Chemical

Product number: 29248
Product name: SAR20347
Packaging: 5mg
Price: $120
Updated: 2024/03/01

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SAR-20347 Chemical Properties,Usage,Production

Uses

SAR-20347 is a small molecule inhibitor with specificity for JAK1 and tyrosine kinase 2 (TYK2).

Biochem/physiol Actions

SAR-20347 is an orally active, ATP-competitive, TYK2- and JAK1-selective tyrosine kinase inhibitor (IC50 = 13 nM/TYK2 & 59 nM/JAK1 vs. 0.88 μM/JAK2 & 1.44 μM/JAK3 with 10 μM ATP) that effectively inhibits cellular TYK2- (IL12-induced pSTAT4 IC50 = 107 nM/CD4+ cells, 126 nM/NK-92) and JAK1- (IL6-induced pSTAT3 IC50 = 345 nM/TF-1, 407 nM/CD14+ cells) mediated signaling with little affinity toward 72 other kinases. SAR-20347 suppresses IL22-induced serum amyloid A (by 44%; 50 mg/kg p.o. 30 min prior to 10 μg IL22 i.p.) and alleviates imiquimod-induced psoriasis-like dermatitis (30 min prior and 5 h post daily 62.5 mg 5% imiquimod cream) in mice in vivo.

SAR-20347 Preparation Products And Raw materials

Raw materials

Preparation Products

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1450881-55-6, SAR-20347Related Search:

SAR 131675 SAR-020106 SAR245409 SAR125844 SAR407899

SAR-20347

CPDD1211

2-(2-chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide

2-(2-chloro-6-fluorophenyl)-5-({4-[(morpholin-4-yl)carbonyl]phenyl}amino)-1,3-oxazole-4-carboxylic acid amide

CS-2527

SAR-20347;SAR 20347;SAR20347

4-Oxazolecarboxamide, 2-(2-chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-

inhibit,SAR 20347,Janus kinase,JAK,SAR-20347,Inhibitor

1450881-55-6

1450881-50-6

JAK1 & TYK2