ChemicalBook > CAS DataBase List > SAR125844

SAR125844

Product Name
SAR125844
CAS No.
1116743-46-4
Chemical Name
SAR125844
Synonyms
SAR125884;SAR125844;SAR125844 /SAR-125844;SAR125844; SAR 125844; SAR-125844;SAR125884 hydrochlorid (1116743-46-4(free base));Inhibitor,SAR125844,c-Met/HGFR,inhibit,SAR 125844,SAR-125844,Apoptosis;1-(6-((6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea;Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-;1-[6-[[6-(4-Fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-[2-(morpholin-4-yl)ethyl]urea
CBNumber
CB22668390
Molecular Formula
C25H23FN8O2S2
Formula Weight
550.63
MOL File
1116743-46-4.mol
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SAR125844 Property

storage temp. 
Store at -20°C
solubility 
DMSO : 45 mg/mL (81.72 mM)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0006341
Product name
SAR125844
Purity
99.03%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0006341
Product name
SAR125844
Purity
99.03%
Packaging
10mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-0006341
Product name
SAR125844
Purity
99.03%
Packaging
50mg
Price
$750
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573075
Product name
SAR125844
Purity
>98%
Packaging
100mg
Price
$1208.7
Updated
2021/12/16
ChemScene
Product number
CS-0006341
Product name
SAR125844
Purity
99.03%
Packaging
100mg
Price
$1300
Updated
2021/12/16
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SAR125844 Chemical Properties,Usage,Production

Biological Activity

SAR125844 is a potent and highly selective Met (c-Met) kinase inhibitor with nanomolar activity against wild-type Met (c-Met) kinase (IC50=4.2 nM), against H1094Y, Y1235D, M1250T, The IC50s of the L1195V and D1228H mutants were 0.22, 1.7, 6.5, 65 and 81 nM, respectively.

in vitro

SAR125844 is an ATP-competitive and reversible inhibitor. SAR125844 has moderate activity against RON, a homolog that is structurally similar to MET, and SAR125844 inhibits RON with an IC50 of approximately 740 nM. SAR125844 is more than 100-fold more selective for MET kinase than for RON.

in vivo

In a pharmacokinetic study in mice, the oral bioavailability of SAR125844 was low, approximately 2%. Its Caco-2 permeability is moderate. In female SCID mice bearing xenograft tumors (inoculated with the MET-expanded Hs 746T human gastric tumor cell line), a single intravenous injection of 20 mg/kg of SAR125844 resulted in a plasma exposure of 6190 h ng/kg mL, clearance CL = 3.1 L/h/kg, large volume of distribution (Vss = 4.2 L/kg).

SAR125844 Preparation Products And Raw materials

Raw materials

Preparation Products

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SAR125844 Suppliers

China 40 India 1 United States 4 Global 45
Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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Shanghai JiYi Biotechnology Co. Ltd.
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13621943973
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sales@shjiyipharmatech.com
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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SPIRO PHARMA
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eric_feng1954@126.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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Shanghai SuperLan Chemcial Technique Centre
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lucy@atkchemical.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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Shanghai Biopharmaleader Co., Ltd.
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+86 18721201413
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Shanghai Medicil Biomedical Co., Ltd.
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marketing@medicilon.com.cn
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TOSUN PHARM
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020-61855200 13326451905
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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DC Chemicals
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Changzhou Chenhong Biotechnology Co., Ltd.
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Jingmo (Xiamen) Biotechnology Co., Ltd
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Guangzhou Younan Technology Co., Ltd
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020-82000279 18988968278
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Shanghai hongqu biomedical technology co. LTD
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hongquchem@qq.com
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Energy Chemical
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Shanghai Dexuan Pharmaceutical Technology Co., Ltd
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Wuhan Topule
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Shanghai tingchong biology science and technology co., ltd
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Bide Pharmatech Ltd.
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InvivoChem
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Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
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TargetMol Chemicals Inc.
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Shanghai Tachizaki Biomedical Research Center
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Nanjing Tengyi Biotechnology Co., Ltd
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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https://hanhongsci.com/
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Nanjing Shizhou Biology Technology Co.,Ltd
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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TargetMol Chemicals Inc.
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Olix (Shanghai) Pharmaceutical Technology Co., Ltd
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ATK CHEMICAL COMPANY LIMITED
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career henan chemical co
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ShenZhen Trendseen Biological Technology Co.,Ltd.
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Guangzhou Tosun Pharmaceutical Limited
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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View Lastest Price from SAR125844 manufacturers

Career Henan Chemical Co
Product
SAR125844 1116743-46-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week 100kg
Release date
2019-09-05

1116743-46-4, SAR125844Related Search:

SAR 131675 SAR-020106 SAR245409 SAR-20347 SAR407899

  • SAR125884
  • SAR125884 hydrochlorid (1116743-46-4(free base))
  • SAR125844; SAR 125844; SAR-125844
  • SAR125844
  • 1-[6-[[6-(4-Fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-[2-(morpholin-4-yl)ethyl]urea
  • SAR125844 /SAR-125844
  • Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-
  • 1-(6-((6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea
  • Inhibitor,SAR125844,c-Met/HGFR,inhibit,SAR 125844,SAR-125844,Apoptosis
  • 1116743-46-4
  • C25H23FN8O2S2