2-Amino-3-chloropyrazine
- Product Name
- 2-Amino-3-chloropyrazine
- CAS No.
- 6863-73-6
- Chemical Name
- 2-Amino-3-chloropyrazine
- Synonyms
- 3-Chloropyrazin-2-amine;TIMTEC-BB SBB006510;1H-IMIDAZOL-1-AMIN...;Pyrazinamine, 3-chloro-;3-Chloro-2-pyrazinamine;2-AMINO-3-CHLOROPYRAZINE;3-AMINO-PYRAZINECHLORIDE;2-Chloro-3-aminopyrazine;3-AMINO-2-CHLORO-PYRAZINE;2-PyrazinaMine, 3-chloro-
- CBNumber
- CB0298955
- Molecular Formula
- C4H4ClN3
- Formula Weight
- 129.55
- MOL File
- 6863-73-6.mol
2-Amino-3-chloropyrazine Property
- Melting point:
- 167-171°C
- Boiling point:
- 248.1±35.0 °C(Predicted)
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 2.37±0.10(Predicted)
- color
- White to Light yellow to Dark green
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C4H4ClN3/c5-3-4(6)8-2-1-7-3/h1-2H,(H2,6,8)
- InChIKey
- AEVSSZHXGJAPIE-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CN=C1Cl
- CAS DataBase Reference
- 6863-73-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A2143
- Product name
- 2-Amino-3-chloropyrazine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- A2143
- Product name
- 2-Amino-3-chloropyrazine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $71
- Updated
- 2025/07/31
- Product number
- C379475
- Product name
- 3-Chloro-2-pyrazinamine
- Packaging
- 5g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- COR0001607
- Product name
- 2-AMINO-3-CHLOROPYRAZINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $808.89
- Updated
- 2021/12/16
- Product number
- COR0001607
- Product name
- 2-AMINO-3-CHLOROPYRAZINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1065.66
- Updated
- 2021/12/16
2-Amino-3-chloropyrazine Chemical Properties,Usage,Production
Uses
It is employed in the synthesis and tuberculostatic activity of N-pyrazinylthiourea.
Synthesis
4858-85-9
6863-73-6
General procedure for the synthesis of 2-amino-3-chloropyrazine from 2,3-dichloropyrazine: 2,3-dichloropyrazine (3.5 g, 0.023 mol) was suspended in a mixture of 25% ammonia (20 mL) and tetrahydrofuran (THF, 20 mL) in an autoclave reactor and heated to react for 18 h at 100 °C. The reaction was completed by cooling to room temperature. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated under reduced pressure to a minimum volume. The residue was ground with distilled water (15 mL) and after filtration, the solid product was dried to give 2-amino-3-chloropyrazine as a light yellow crystalline solid (2.75 g, 90% yield). Mass spectrum (electrospray positive ionization mode, ES+) m/z: 130.1. 1H NMR (400 MHz, CDCl3): δ 7.94 (d, J=2.53 Hz, 1H), 7.72 (d, J=2.53 Hz, 1H), 4.90-5.12 (broad single peak, 2H).
References
[1] Patent: US2012/59162, 2012, A1. Location in patent: Page/Page column 38-39
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4196 - 4212
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3454 - 3459
[4] Patent: US2014/364414, 2014, A1. Location in patent: Paragraph 0438-0440
[5] Patent: WO2010/69684, 2010, A1. Location in patent: Page/Page column 96
2-Amino-3-chloropyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-3-chloropyrazine manufacturers
- Product
- 2-Amino-3-chloropyrazine 6863-73-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02
- Product
- 2-Amino-3-chloropyrazine 6863-73-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500t/month
- Release date
- 2023-08-18
- Product
- 2-Amino-3-chloropyrazine 6863-73-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-12