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Paramethasone

Product Name
Paramethasone
CAS No.
53-33-8
Chemical Name
Paramethasone
Synonyms
Cortiden;PARAMETHASONE;Picaridin Impurity 9;6a-Fluoro-16a-methylprednisolone;16a-Methyl-6a-fluoroprednisolone;6-alpha-fluoro-16-alpha-methylprednisolone;Methylprednisolone Impurity 30 (Paramethasone);1, 4-PREGNADIEN-6α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE;6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione;6a-fluoro-11b,17a,21-trihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione
CBNumber
CB0301372
Molecular Formula
C22H29FO5
Formula Weight
392.46
MOL File
53-33-8.mol
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Paramethasone Property

Melting point:
228-241°C
Boiling point:
573.5±50.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
12.34±0.70(Predicted)
color 
White to Pale Beige
CAS DataBase Reference
53-33-8
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Safety

Hazardous Substances Data
53-33-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
P191840
Product name
Paramethasone
Packaging
2.5mg
Price
$185
Updated
2021/12/16
TRC
Product number
P191840
Product name
Paramethasone
Packaging
25mg
Price
$1455
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
60958
Product name
Paramethasone
Packaging
25mg
Price
$2200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0007268
Product name
PARAMETHASONE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0007268
Product name
PARAMETHASONE
Purity
95.00%
Packaging
10G
Price
$1334.03
Updated
2021/12/16
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Paramethasone Chemical Properties,Usage,Production

Originator

Haldrone,Lilly,US,1961

Uses

Paramethasone, is a fluorinated glucocorticoid, having anti-inflammatory and immunosuppressant properties.

Uses

Glucocorticoid.

Definition

ChEBI: Paramethasone is a fluorinated steroid.

Manufacturing Process

A solution of 0.144 g of the 3-ethylene glycol ketal of 5α,11β,17α,21 tetrahydroxy-6β-fluoro-16α-methylallopregnane-3,20-dione-21 acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an icesalt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°C and -15°C. The solution was then diluted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at 60°C or less to give 6α-fluoro-11β,17α,21-trihydroxy-16α-methyl-4-pregnene3,20-dione 21-acetate.

brand name

Haldrone (Lilly).

Therapeutic Function

Glucocorticoid

Paramethasone Preparation Products And Raw materials

Raw materials

Preparation Products

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Paramethasone Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Amfinecom Inc.
Tel
--
Fax
--
Email
sales@amfinecom.com
Country
United States
ProdList
3062
Advantage
50
Altan Corporation
Tel
--
Fax
--
Email
OrderingService@AltanBiochemicals.com
Country
United States
ProdList
1161
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Steraloids Inc.
Tel
--
Fax
--
Email
sales@steraloids.com
Country
United States
ProdList
2357
Advantage
68

53-33-8, ParamethasoneRelated Search:


  • 16a-Methyl-6a-fluoroprednisolone
  • 6a-Fluoro-16a-methylprednisolone
  • Cortiden
  • Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16a-methyl- (8CI)
  • Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16-methyl- (7CI)
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)- (9CI)
  • (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
  • PARAMETHASONE
  • 6a-fluoro-11b,17a,21-trihydroxy-16a-methyl-1,4-pregnadiene-3,20-dione
  • 6-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
  • 6-alpha-fluoro-16-alpha-methylprednisolone
  • 1,4-PREGNADIEN-6-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
  • (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • 6-fluoro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
  • Pregna-1,4-diene-3,20-dione,6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)-
  • Methylprednisolone Impurity 30 (Paramethasone)
  • 1, 4-PREGNADIEN-6α-FLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE
  • Picaridin Impurity 9
  • 53-33-8