ChemicalBook > CAS DataBase List > 4-(Methylthio)benzaldehyde

4-(Methylthio)benzaldehyde

Product Name
4-(Methylthio)benzaldehyde
CAS No.
3446-89-7
Chemical Name
4-(Methylthio)benzaldehyde
Synonyms
MTAD;4-ALDEHYDE THIOANISOLE;P-(METHYLTHIO)BENZALDEHYDE;p-Methylmercaptobenzaldehyde;4-(Methylsulfanyl)benzaldehyde;thio)benzaL;AKOS BBS-00003173;4-Thioanisaldehyde;4-Formylthioanisole;4-(methylthio)-benzaldehyd
CBNumber
CB0307859
Molecular Formula
C8H8OS
Formula Weight
152.21
MOL File
3446-89-7.mol
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4-(Methylthio)benzaldehyde Property

Melting point:
6 °C
Boiling point:
86-90 °C1 mm Hg(lit.)
Density 
1.144 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.646(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Liquid
Specific Gravity
1.144
color 
Clear yellow
Water Solubility 
Not miscible in water.
Sensitive 
Stench
BRN 
636158
InChIKey
QRVYABWJVXXOTN-UHFFFAOYSA-N
LogP
2.24 at 30℃
CAS DataBase Reference
3446-89-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 4-(methylthio)-(3446-89-7)
EPA Substance Registry System
Benzaldehyde, 4-(methylthio)- (3446-89-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-24/25-36-26-7/9
RIDADR 
UN 3334
WGK Germany 
3
F 
13
Hazard Note 
Irritant/Stench
TSCA 
Yes
HS Code 
29309070
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
222771
Product name
4-(Methylthio)benzaldehyde
Purity
95%
Packaging
10g
Price
$47.5
Updated
2025/07/31
Sigma-Aldrich
Product number
222771
Product name
4-(Methylthio)benzaldehyde
Purity
95%
Packaging
50g
Price
$140
Updated
2025/07/31
TCI Chemical
Product number
M0739
Product name
4-(Methylthio)benzaldehyde
Purity
>97.0%(GC)
Packaging
25g
Price
$43
Updated
2025/07/31
TCI Chemical
Product number
M0739
Product name
4-(Methylthio)benzaldehyde
Purity
>97.0%(GC)
Packaging
250g
Price
$200
Updated
2025/07/31
TRC
Product number
M330660
Product name
4-(Methylthio)benzaldehyde
Packaging
10g
Price
$110
Updated
2021/12/16
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4-(Methylthio)benzaldehyde Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

4-(Methylthio)benzaldehyde is a building block for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the synthesis of sulfur-containing terpyridine ligands. It is the intermediate for the synthesis of a class of pyrrole derivatives showing analgesic/anti-inflammatory activity.

Synthesis Reference(s)

Synthetic Communications, 24, p. 2665, 1994 DOI: 10.1080/00397919408010580

Synthesis

37794-15-3

3446-89-7

In the standard synthetic method, diphenyl sulfoxide (2.2 g, 0.01 mol) is mixed with brominated silica (18.18 g, 40 mmol Br/g silica) in a nonprotonic solvent such as dichloromethane (2 mL) or carbon tetrachloride. The reaction was carried out at room temperature while atmospheric water needed to be removed for 5 min. Upon completion of the reaction, the product was separated by simple filtration, followed by evaporation of the solvent to give diphenyl sulfide in its pure state (yield 1.84 g, 99%).

References

[1] Synthetic Communications, 2007, vol. 37, # 22, p. 4079 - 4083
[2] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 8, p. 2525 - 2526
[3] Tetrahedron Letters, 2009, vol. 50, # 49, p. 6872 - 6876
[4] Journal of Sulfur Chemistry, 2014, vol. 35, # 1, p. 7 - 13
[5] Journal of Sulfur Chemistry, 2017, vol. 38, # 6, p. 597 - 603

4-(Methylthio)benzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

4-(METHYLTHIO)BENZYLAMINE Sulindac
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4-(Methylthio)benzaldehyde Suppliers

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View Lastest Price from 4-(Methylthio)benzaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-(Methylthio)benzaldehyde 3446-89-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-18
Shaanxi Dideu Medichem Co. Ltd
Product
4-(Methylthio)benzaldehyde 3446-89-7
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(Methylthio)benzaldehyde 3446-89-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

3446-89-7, 4-(Methylthio)benzaldehydeRelated Search:

Mercaptoacetic acid p-Tolualdehyde 2-(Trifluoromethyl)benzaldehyde 3-Mercaptopropionic acid 3-Methoxybenzaldehyde 3-(Trifluoromethyl)benzaldehyde 2-Ethylhexyl mercaptoacetate 4-Hydroxybenzaldehyde 4-Dimethylaminobenzaldehyde o-Anisaldehyde ISOMETHIOZIN p-Anisaldehyde Benzaldehyde Calcium thioglycolate Anisonitrile 4-Methoxycinnamic acid 3,3,4,4-diphenylsulfonetetracarboxylicdianhydride 2-Mercaptoethanol

  • 4-(methylthio)-benzaldehyd
  • p-Methylmercaptobenzaldehyde
  • METHYLMERCAPTOBENZALDEHYDE(4-)
  • 4-ALDEHYDE THIOANISOLE
  • 4-METHYLMERCAPTOBENZALDEHYDE
  • (4-METHYLTHIOCYCLOHEXYL)METHANOL
  • 4-(METHYLTHIO)BENZALDEHYDE
  • AKOS BBS-00003173
  • 4-(Methylthio)benzaldehyde, 4-Thioanisaldehyde, P-(Methylthio)benzaldehyde
  • 4-(Methylthio)Benzaldehyde97%
  • 4-Thioanisaldehyde
  • PARA-METHYLTHIOBENZALDEHYDE
  • 4-(METHYLTHIO)BENZALDEHYDE / 4-THIOANISALDEHYDE
  • 4-(METHYLTHIO)BENZALDEHYDE 98+%
  • Methyl 4-formylphenyl sulfide
  • Methyl(4-formylphenyl) sulfide
  • 4-(METHYLTHIO)BENZALDEHYDE (4-ALDEHYDETHIOANISOLE)
  • 4-(Methylthio)benzaldehyde,4-(Methylmercapto)benzaldehyde
  • 4-MercaptoMethyl-benzaldehyde
  • 4-Formylthioanisole, 4-(Methylmercapto)benzaldehyde
  • 4-(Methylthio)benzaldehyde, 97% 5ML
  • P-(METHYLTHIO)BENZALDEHYDE
  • MTAD
  • 4-(Methylsulfanyl)benzaldehyde
  • thio)benzaL
  • 4-(Methylthio)benzaldehyde&gt
  • Benzaldehyde, 4-(methylthio)-
  • 4-Formylthioanisole
  • TIANFU-CHEM - 4-(Methylthio)benzaldehyde
  • 3446-89-7
  • CH3SC6H4CHO
  • Organic Building Blocks
  • Carbonyl Compounds
  • Aldehydes
  • Building Blocks
  • C8
  • Aromatic Aldehydes & Derivatives (substituted)