ChemicalBook > CAS DataBase List > 4-AMINO-2-FLUOROPHENOL

4-AMINO-2-FLUOROPHENOL

Product Name
4-AMINO-2-FLUOROPHENOL
CAS No.
399-96-2
Chemical Name
4-AMINO-2-FLUOROPHENOL
Synonyms
4-Amino-2-fluorophenol 98%;2-Fluoro-4-Aminophenol;4-Amino-2-fL;Antipyrine Impurity 7;4-AMINO-2-FLUOROPHENOL;Regorafenib Impurity 78;3-Fluoro-4-hydroxyaniline;4-Amino-2-fluorophenol98%;Phenol, 4-amino-2-fluoro-;4-Amino-2-fluorophenol >
CBNumber
CB0309974
Molecular Formula
C6H6FNO
Formula Weight
127.12
MOL File
399-96-2.mol
More
Less

4-AMINO-2-FLUOROPHENOL Property

Melting point:
170-172°C
Boiling point:
263.3±25.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
Amber Vial, Refrigerator, Under Inert Atmosphere
solubility 
DMSO, Methanol
form 
Solid
pka
8.97±0.18(Predicted)
color 
Brown
InChI
InChI=1S/C6H6FNO/c7-5-3-4(8)1-2-6(5)9/h1-3,9H,8H2
InChIKey
MXJQJURZHQZLNN-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(N)C=C1F
CAS DataBase Reference
399-96-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2922290090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
A2163
Product name
4-Amino-2-fluorophenol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
A2163
Product name
4-Amino-2-fluorophenol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$229
Updated
2025/07/31
TRC
Product number
A609630
Product name
4-Amino-2-fluorophenol
Packaging
50g
Price
$140
Updated
2021/12/16
TRC
Product number
A609630
Product name
4-Amino-2-fluorophenol
Packaging
5g
Price
$50
Updated
2021/12/16
Usbiological
Product number
161186
Product name
4-Amino-2-fluorophenol
Packaging
1g
Price
$319
Updated
2021/12/16
More
Less

4-AMINO-2-FLUOROPHENOL Chemical Properties,Usage,Production

Uses

4-Amino-2-fluorophenol is an reagent used in various synthetic preparations such as the synthesis of Amodiaquine (A634200), an antimalarial agent.

Synthesis

403-19-0

399-96-2

Step 1) Reduction reaction: 2-fluoro-4-nitrophenol (5.0 g, 31.8 mmol) was dissolved in methanol (200 mL) and palladium/carbon catalyst (1.0 g, 10%) was added. The reaction mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with methanol (5 mL). The filtrate was concentrated under reduced pressure to give 4-amino-2-fluorophenol as a brown solid (4.02 g, yield >99%). Mass spectrum (ESI, cation mode) m/z: 128.1 [M+H]+.

References

[1] Patent: US2005/245530, 2005, A1. Location in patent: Page/Page column 35-36
[2] Patent: US2006/241104, 2006, A1. Location in patent: Page/Page column 14
[3] Patent: US2007/78140, 2007, A1. Location in patent: Page/Page column 25-26
[4] Patent: WO2014/22116, 2014, A2. Location in patent: Paragraph 0223
[5] Patent: US2015/37280, 2015, A1. Location in patent: Paragraph 0445; 0446

4-AMINO-2-FLUOROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-AMINO-2-FLUOROPHENOL Suppliers

Americas 1 Canada 1 China 189 Europe 3 Germany 2 India 5 Italy 1 Japan 1 United Kingdom 15 United States 19 Global 237
Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
021-31038972,31038973 17321035817
Fax
+86-21-51385350
Email
sales@harvest-chem.com
Country
China
ProdList
2816
Advantage
64
Shandong Yunxing Pharmaceutical R&D Co., Ltd
Tel
13153019312
Email
3977218233@qq.com
Country
China
ProdList
39
Advantage
58
Shaoxing Hengchuang Heyi Biotechnology Co., Ltd
Tel
15158234258
Email
3991135489@qq.com
Country
China
ProdList
233
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
More
Less

View Lastest Price from 4-AMINO-2-FLUOROPHENOL manufacturers

Hebei Fengjia New Material Co., Ltd
Product
4-AMINO-2-FLUOROPHENOL 399-96-2
Price
US $4.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-09-09
Hebei Yanxi Chemical Co., Ltd.
Product
4-AMINO-2-FLUOROPHENOL 399-96-2
Price
US $50.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/month
Release date
2024-03-28
Shaanxi Dideu New Materials Co. Ltd
Product
4-AMINO-2-FLUOROPHENOL 399-96-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-02

399-96-2, 4-AMINO-2-FLUOROPHENOLRelated Search:

4-METHOXY-3-NITROBENZOTRIFLUORIDE 3-Fluoro-4-methoxyaniline 4-AMINO-2-FLUOROPHENOL 3-Amino-4-fluorophenol 4-Amino-3-Fluorophenol 3-Fluoro-4-Aminophenol,4-AMINO-3-FLUOROPHENOL,4-Amino-3-fluorophenol98%,4-Amino-3-fluorophenol 98%,4-AMINO-3-FLUOROPHENOL, 98% MIN. 2-AMINO-5-FLUOROPHENOL,2-Amino-5-fluorophenol98%,2-Amino-5-fluorophenol 98% 2-Amino-4-fluorophenol98%,2-Amino-4-fluorophenol 98%,2-AMINO-4-FLUOROPHENOL 4-Amino-3-fluorophenol, HCl,4-Amino-3-fluorophenol,hydrochloride 2-Fluorophenol 3-(2-FLUORO-4-NITROPHENOXY)-2-THIOPHENECARBOXYLIC ACID METHYL 3-(2-FLUORO-4-NITROPHENOXY)-2-THIOPHENECARBOXYLATE 2-AMINO-3-FLUOROPHENOL 2-FLUORO-4-NITROPHENOL N-(3,5-DICHLOROPHENYL)-3-(2-FLUORO-4-NITROPHENOXY)-2-THIOPHENECARBOXAMIDE N-(2,4-DICHLORO-5-METHOXYPHENYL)-3-(2-FLUORO-4-NITROPHENOXY)-2-THIOPHENECARBOXAMIDE N-(2,4-DICHLORO-5-ISOPROPOXYPHENYL)-3-(2-FLUORO-4-NITROPHENOXY)-2-THIOPHENECARBOXAMIDE 3-(2-FLUORO-4-NITROPHENOXY)-N-[4-(TRIFLUOROMETHYL)PHENYL]-2-THIOPHENECARBOXAMIDE N-ALLYL-3-(2-FLUORO-4-NITROPHENOXY)-2-THIOPHENECARBOXAMIDE

  • 4-AMINO-2-FLUOROPHENOL
  • 2-Fluoro-4-Aminophenol
  • 4-Amino-2-fluorophenol 98%
  • 4-Amino-2-fluorophenol98%
  • 3-Fluoro-4-hydroxyaniline
  • 4-Amino-2-fluorophenol &gt
  • 4-Amino-2-fL
  • Phenol, 4-amino-2-fluoro-
  • Regorafenib Impurity 78
  • 4-AMINO-2-FLUOROPHENOL ISO 9001：2015 REACH
  • Antipyrine Impurity 7
  • 399-96-2
  • C6H6FNO
  • Fluorine series
  • Aromatic Phenols
  • Phenol&Thiophenol&Mercaptan
  • bc0001