COH-29

Product Name: COH-29
CAS No.: 1190932-38-7
Chemical Name: COH-29
Synonyms: COH-29;181687;CS-2737;COH-29 ，S0283;COH-29; COH 29;RNR Inhibitor COH29;COH29, 10 mM in DMSO;N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide;N-[4-(3,4-Dihydroxyphenyl)-5-phenyl-2-thiazolyl]-3,4-dihydroxybenzamide;Benzamide, N-[4-(3,4-dihydroxyphenyl)-5-phenyl-2-thiazolyl]-3,4-dihydroxy-
CBNumber: CB03145900
Molecular Formula: C22H16N2O5S
Formula Weight: 420.44
MOL File: 1190932-38-7.mol

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COH-29 Property

storage temp.: Store at -20°C
solubility: DMSO:45.0(Max Conc. mg/mL);107.03(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.78(Max Conc. mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6153
Product name: COH29
Purity: 98.22%
Packaging: 1mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-6153
Product name: COH29
Purity: 98.22%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6153
Product name: COH29
Purity: 98.22%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-6153
Product name: COH29
Purity: 98.22%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-6153
Product name: COH29
Purity: 98.22%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

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COH-29 Chemical Properties,Usage,Production

Uses

COH29 (RNR Inhibitor COH29) is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits α and β subunit of RNR with IC50s of 16 μM.

in vivo

COH29 results in a dose-dependent inhibition of MOLT-4 tumor xenograft growth with twice-daily oral dosing at 50 mg/kg and 100 mg/kg, which is pronounced by Day 12 of treatment. Similarly, 7 days of treatment of mice bearing TOV11D xenografts with 200, 300, or 400 mg/kg/day COH29 results in a dose-dependent inhibition of tumor xenograft growth. Tumor growth is significantly inhibited compared with the control group^[1].

References

[1] Zhou B, et al. A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.Cancer Res. 2013 Nov 1;73(21):6484-93. DOI:10.1158/0008-5472.CAN-13-1094
[2] Chen MC, et al. The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro. Mol Pharmacol. 2015 Jun;87(6):996-1005. DOI:10.1124/mol.114.094987

COH-29 Preparation Products And Raw materials

Raw materials

Preparation Products

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COH-29 Suppliers

China 59 India 1 United States 7 Global 67

ChemShuttle, Inc.

Tel: 0510-83588313-811 18800520310
Email: sales@chemshuttle.com
Country: China
ProdList: 2999
Advantage: 62

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12476
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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

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View Lastest Price from COH-29 manufacturers

Career Henan Chemical Co

Product: COH-29 1190932-38-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

1190932-38-7, COH-29Related Search:

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COH-29

N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide

181687

COH-29; COH 29

CS-2737

RNR Inhibitor COH29

Benzamide, N-[4-(3,4-dihydroxyphenyl)-5-phenyl-2-thiazolyl]-3,4-dihydroxy-

ribonucleotide,RNR,inhibit,COH-29,reductase,DNA/RNA Synthesis,COH29,RNR Inhibitor COH-29,subunit,COH 29,RNR Inhibitor COH 29,Inhibitor,anticancer

N-[4-(3,4-Dihydroxyphenyl)-5-phenyl-2-thiazolyl]-3,4-dihydroxybenzamide

COH29, 10 mM in DMSO

COH-29 ，S0283

1190932-38-7