2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide

Product Name: 2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide
CAS No.: 1462267-08-8
Chemical Name: 2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide
Synonyms: ML266;133974;CS-2740;CID-4694321;CID-46943215;ML266, 10 mM in DMSO;2-[(2-{[(4-bromophenyl)carbamoyl]methoxy}phenyl)formamido]-N-methyl-N-phenylacetamide;2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide;Benzamide, 2-[2-[(4-bromophenyl)amino]-2-oxoethoxy]-N-[2-(methylphenylamino)-2-oxoethyl]-
CBNumber: CB13049643
Molecular Formula: C24H22BrN3O4
Formula Weight: 496.35
MOL File: 1462267-08-8.mol

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2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide Property

Boiling point:: 724.2±60.0 °C(Predicted)
Density: 1.445±0.06 g/cm3(Predicted)
pka: 12.31±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BRS0009215
Product name: 2-(2-((4-BROMOPHENYL)AMINO)-2-OXOETHOXY)-N-(2-(METHYL(PHENYL)AMINO)-2-OXOETHYL)BENZAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $504.9
Updated: 2021/12/16

DC Chemicals

Product number: DC43043
Product name: ML266
Purity: >98%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

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2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide Chemical Properties,Usage,Production

Uses

ML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 μM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease[1].

References

[1] Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7]. PMID:23762943

2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide Suppliers

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1462267-08-8, 2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamideRelated Search:

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2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide

CID-46943215

ML266

133974

CS-2740

Benzamide, 2-[2-[(4-bromophenyl)amino]-2-oxoethoxy]-N-[2-(methylphenylamino)-2-oxoethyl]-

CID-4694321

2-[(2-{[(4-bromophenyl)carbamoyl]methoxy}phenyl)formamido]-N-methyl-N-phenylacetamide

ML266, 10 mM in DMSO

1462267-08-8