Q-VD-OPh hydrate

Product Name: Q-VD-OPh hydrate
CAS No.: 1135695-98-5
Chemical Name: Q-VD-OPh hydrate
Synonyms: CS-2734;Q-VD-OPh hydrate;Q-VD-OPh (QVD-OPH;Quinoline-Val-Asp-Difluorophenoxymethylketone);QVD-OPH;QUINOLINE-VAL-ASP-DIFLUOROPHENOXYMETHYLKETONE;QVD-OPH,QVDOPH,inhibit,Caspase,Human immunodeficiency virus,Inhibitor,HIV,Q VD OPH;(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid;Pentanoic acid, 5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-, (3S)-;(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate
CBNumber: CB42652283
Molecular Formula: C26H25F2N3O6
Formula Weight: 513.49
MOL File: 1135695-98-5.mol

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Q-VD-OPh hydrate Property

Boiling point:: 808.9±65.0 °C(Predicted)
Density: 1.346±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: -20°C
solubility: DMSO: ≥14mg/mL
pka: 3.92±0.19(Predicted)
form: powder
color: white to light brown
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey: OOBJCYKITXPCNS-REWPJTCUSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0063
Product name: Q-VD-OPh hydrate
Purity: ≥95% (HPLC)
Packaging: 1mg
Price: $258
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0063
Product name: Q-VD-OPh hydrate
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $1030
Updated: 2024/03/01

Cayman Chemical

Product number: 15260
Product name: Q-VD-OPH
Purity: ≥95% (mixture of tautomers)
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 15260
Product name: Q-VD-OPH
Purity: ≥95% (mixture of tautomers)
Packaging: 5mg
Price: $423
Updated: 2024/03/01

TRC

Product number: D446120
Product name: (3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoicAcid
Packaging: 25mg
Price: $1260
Updated: 2021/12/16

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Q-VD-OPh hydrate Chemical Properties,Usage,Production

Description

Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 μM. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK and Boc-D-FMK . Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis. This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.

Uses

Q-VD-OPh hydrate has been used:

as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)
to induce canonical caspase-dependent apoptosis in UC cells
to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)
to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells

Uses

An inhibitor that is used in Alzheimer’s studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor.

Biochem/physiol Actions

Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.

target

caspase-1

storage

+4°C

References

1) Caserta?et al.?(2003),?Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties; Apoptosis,?8?345 2) Braun?et al.?(2007),?Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol.,?206?183 3) Rebbaa?et al.?(2003),?Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene,?22?2805 4) Bulatovic?et al.?(2015),?Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One,?10?e0120176 5) Bailey?et al. (2017),?Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis;?Cell Death Dis.,?8?e2590

Q-VD-OPh hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Q-VD-OPh hydrate Suppliers

Canada 1 China 86 India 1 United States 13 USA 1 Global 102

Jiangsu Shenlang Biotechnology Co., Ltd.

Tel: 18914398991
Fax: 0513-81001007
Email: 1582941412@qq.com
Country: China
ProdList: 21
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Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: eric@peptidego.com
Country: China
ProdList: 6347
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Hangzhou Beiputai Biopharmaceutical Co., Ltd

Tel: 0571-85350119 13305819357
Email: bptsales@163.com
Country: China
ProdList: 3577
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
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ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
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View Lastest Price from Q-VD-OPh hydrate manufacturers

Career Henan Chemical Co

Product: Q-VD-OPh hydrate 1135695-98-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 2tons
Release date: 2019-12-19

1135695-98-5, Q-VD-OPh hydrateRelated Search:

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Q-VD-OPh hydrate

(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid

(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate

Quinoline-Val-Asp-Difluorophenoxymethylketone)

CS-2734

Q-VD-OPh (QVD-OPH

QVD-OPH;QUINOLINE-VAL-ASP-DIFLUOROPHENOXYMETHYLKETONE

Pentanoic acid, 5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-, (3S)-

QVD-OPH,QVDOPH,inhibit,Caspase,Human immunodeficiency virus,Inhibitor,HIV,Q VD OPH

1135695-98-5

C26H25F2N3O6xH2O

C26H25F2N3O6

Apoptosis