ChemicalBook > CAS DataBase List > N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

Product Name
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
CAS No.
211311-95-4
Chemical Name
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
Synonyms
100775;CS-2739;LY40418;LY404187;LY-404187; LY 404187;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide;N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
CBNumber
CB42640286
Molecular Formula
C19H22N2O2S
Formula Weight
342.46
MOL File
211311-95-4.mol
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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Property

Boiling point:
519.0±60.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
form 
A solid
pka
11.24±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28741
Product name
LY404187
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
28741
Product name
LY404187
Packaging
50mg
Price
$542
Updated
2024/03/01
Cayman Chemical
Product number
28741
Product name
LY404187
Packaging
10mg
Price
$175
Updated
2024/03/01
Cayman Chemical
Product number
28741
Product name
LY404187
Packaging
25mg
Price
$352
Updated
2024/03/01
Tocris
Product number
5297
Product name
LY404187
Purity
≥98%(HPLC)
Packaging
10
Price
$210
Updated
2021/12/16
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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Chemical Properties,Usage,Production

Description

LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.

Uses

LY 404187 is a novel positive allosteric modulator of AMPA receptors.

storage

Store at +4°C

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Suppliers

China 52 United Kingdom 2 United States 12 USA 1 Global 67
Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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ChemShuttle, Inc.
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0510-83588313-802 18800520310;
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sales@chemshuttle.com
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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United States
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CEG Chemical Science&Technology Co., Ltd.
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+86-510-68873513
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Shanghai HuanChuan Industry Co.,Ltd.
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021-61478794
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Shanghai Tombiopharma Chemical Co. Ltd.
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13391076197
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tombiopharma@163.com
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China
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AdooQ Bioscience CHINA
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LETOPHARM LIMITED
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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Watson Biotechnology Co.,Ltd
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211311-95-4, N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMideRelated Search:

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  • N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
  • LY404187
  • N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide
  • N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
  • N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide
  • CS-2739
  • 100775
  • LY-404187; LY 404187
  • LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
  • 2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-
  • N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide
  • GluR2o,inhibit,Allosteric,GluR3i,iGluR,GluR4i,AMPA,Ionotropic glutamate receptors,GluR1i,LY-404187,psychiatric,LY404187,Inhibitor,GluR2i,LY 404187,neurodegenerative
  • LY40418
  • N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide
  • 211311-95-4