N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

Product Name: N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
CAS No.: 211311-95-4
Chemical Name: N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
Synonyms: 100775;CS-2739;LY40418;LY404187;LY-404187; LY 404187;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide;N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
CBNumber: CB42640286
Molecular Formula: C19H22N2O2S
Formula Weight: 342.46
MOL File: 211311-95-4.mol

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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Property

Boiling point:: 519.0±60.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
form: A solid
pka: 11.24±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28741
Product name: LY404187
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 28741
Product name: LY404187
Packaging: 50mg
Price: $542
Updated: 2024/03/01

Cayman Chemical

Product number: 28741
Product name: LY404187
Packaging: 10mg
Price: $175
Updated: 2024/03/01

Cayman Chemical

Product number: 28741
Product name: LY404187
Packaging: 25mg
Price: $352
Updated: 2024/03/01

Tocris

Product number: 5297
Product name: LY404187
Purity: ≥98%(HPLC)
Packaging: 10
Price: $210
Updated: 2021/12/16

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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Chemical Properties,Usage,Production

Description

LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1_i, -2_i, -2_o, -3_i, and -4_i subunit-containing AMPA receptors with EC₅₀ values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC₅₀s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.

Uses

LY 404187 is a novel positive allosteric modulator of AMPA receptors.

storage

Store at +4°C

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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211311-95-4, N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMideRelated Search:

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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

LY404187

N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide

N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide

N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide

CS-2739

100775

LY-404187; LY 404187

LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-

N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide

GluR2o,inhibit,Allosteric,GluR3i,iGluR,GluR4i,AMPA,Ionotropic glutamate receptors,GluR1i,LY-404187,psychiatric,LY404187,Inhibitor,GluR2i,LY 404187,neurodegenerative

LY40418

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide

211311-95-4