4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Product Name: 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS No.: 1818885-63-0
Chemical Name: 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Synonyms: Cereblon Ligand-Linker Conjugates 9;E3 Ligase Ligand-Linker Conjugates 2;Cereblon Ligand-Linker Conjugates 9(E3 Ligase Ligand-Linker Conjugates 2);4-[2-[2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;4-[[2-[2-[2-[2-(4-Aminophenoxy)ethoxy]ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-[12-(4-aminophenoxy)-4,7,10-trioxa-1-azadodecan-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
CBNumber: CB03146639
Molecular Formula: C27H32N4O8
Formula Weight: 540.57
MOL File: 1818885-63-0.mol

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4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Property

Boiling point:: 792.0±60.0 °C(Predicted)
Density: 1.363±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 10.74±0.40(Predicted)
form: Solid
color: Light yellow to yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC26126
Product name: CereblonLigand-LinkerConjugates9
Purity: >98%
Packaging: 100mg
Price: $550
Updated: 2021/12/16

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4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties,Usage,Production

Description

Pomalidomide-PEG4-Ph-NH2 is comprised of the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Pomalidomide-PEG4-Ph-NH2 is used in PROTAC technology as a E3 ligase ligand-linker conjugate that incorporates PEG technology that can be linked to a wide range of "warheads" that bind to proteins of interest.

4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Suppliers

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1818885-63-0, 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneRelated Search:

E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate E3 ligase Ligand-Linker Conjugates 5 Free Base Thalidomide-O-amido-C3-NH2 (TFA) N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt E3 ligase Ligand-Linker Conjugates 17 E3 ligase Ligand-Linker Conjugates 14

4-[2-[2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Cereblon Ligand-Linker Conjugates 9

4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

E3 Ligase Ligand-Linker Conjugates 2

1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

Cereblon Ligand-Linker Conjugates 9(E3 Ligase Ligand-Linker Conjugates 2)

4-[[2-[2-[2-[2-(4-Aminophenoxy)ethoxy]ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione

4-[12-(4-aminophenoxy)-4,7,10-trioxa-1-azadodecan-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

1818885-63-0

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