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ALPHA-CGRP (RAT)

Product Name
ALPHA-CGRP (RAT)
CAS No.
83651-90-5
Chemical Name
ALPHA-CGRP (RAT)
Synonyms
CGRP (RAT);Rat α-CGRP;A-CGRP (RAT);α-CGRP (rat);CGRP (rat) TFA;ALPHA-CGRP (RAT);α-CGRP (mouse, rat);a-CGRP (Mouse, rat);α-CGRP (mouse, rat);alpha-CGRP (mouse, rat)
CBNumber
CB0316219
Molecular Formula
C162H262N50O52S2
Formula Weight
3806.24748
MOL File
83651-90-5.mol
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ALPHA-CGRP (RAT) Property

storage temp. 
−20°C
form 
powder
color 
White to off-white
Water Solubility 
Soluble to 0.80 mg/ml in water
Sequence
H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1161
Product name
CGRP(rat)
Packaging
100U
Price
$165
Updated
2021/12/16
Usbiological
Product number
C0115-01E
Product name
Calcitonin Gene Related Peptide, Rat
Packaging
50ug
Price
$405
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BIO0000315
Product name
CALCITONIN GENE RELATED PEPTIDE (CGRP)-RAT
Purity
95.00%
Packaging
0.5MG
Price
$693
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BIO0000315
Product name
CALCITONIN GENE RELATED PEPTIDE (CGRP)-RAT
Purity
95.00%
Packaging
1MG
Price
$864.7
Updated
2021/12/16
ApexBio Technology
Product number
B5061
Product name
CGRP(rat)
Packaging
100ug
Price
$234
Updated
2021/12/16
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ALPHA-CGRP (RAT) Chemical Properties,Usage,Production

Uses

α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies[1][2][3][4].

in vivo

α-CGRP (mouse, rat) (0.25, 0.5, 1 μg/kg/min, intravenous) dose-dependent decreases mean arterial blood pressure, while heart rate and systemic vascular conduction increased, while cardiac output remained unchanged[3].
α-CGRP (mouse, rat) plays an important role in the regulation of Kainic acid (KA) induced pyramid-cell death in hippocampal CA3 region[4].

storage

Store at -20°C

References

[1] Whitby K, et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol. 2005 Jul;79(14):8698-706. DOI:10.1128/JVI.79.14.8698-8706.2005
[2] Xu H, et al. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9. DOI:10.1016/j.immuni.2019.09.004
[3] Arulmani U, et al. Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats. Basic Clin Pharmacol Toxicol. 2004 Jun;94(6):291-7. DOI:10.1111/j.1742-7843.2004.pto940606.x
[4] Park SH, et al. Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice. Peptides. 2013 Jun;44:158-62. DOI:10.1016/j.peptides.2013.04.001

ALPHA-CGRP (RAT) Preparation Products And Raw materials

Raw materials

Preparation Products

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ALPHA-CGRP (RAT) Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1010
Advantage
55
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Creative Peptides
Tel
Email
info@creative-peptides.com
Country
United States
ProdList
6083
Advantage
56
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4802
Advantage
58

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