ALPHA-CGRP (RAT)
- Product Name
- ALPHA-CGRP (RAT)
- CAS No.
- 83651-90-5
- Chemical Name
- ALPHA-CGRP (RAT)
- Synonyms
- CGRP (RAT);Rat α-CGRP;A-CGRP (RAT);α-CGRP (rat);CGRP (rat) TFA;ALPHA-CGRP (RAT);α-CGRP (mouse, rat);a-CGRP (Mouse, rat);α-CGRP (mouse, rat);alpha-CGRP (mouse, rat)
- CBNumber
- CB0316219
- Molecular Formula
- C162H262N50O52S2
- Formula Weight
- 3806.24748
- MOL File
- 83651-90-5.mol
ALPHA-CGRP (RAT) Property
- storage temp.
- −20°C
- form
- powder
- color
- White to off-white
- Water Solubility
- Soluble to 0.80 mg/ml in water
- Sequence
- H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 1161
- Product name
- CGRP(rat)
- Packaging
- 100U
- Price
- $165
- Updated
- 2021/12/16
- Product number
- C0115-01E
- Product name
- Calcitonin Gene Related Peptide, Rat
- Packaging
- 50ug
- Price
- $405
- Updated
- 2021/12/16
- Product number
- BIO0000315
- Product name
- CALCITONIN GENE RELATED PEPTIDE (CGRP)-RAT
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $693
- Updated
- 2021/12/16
- Product number
- BIO0000315
- Product name
- CALCITONIN GENE RELATED PEPTIDE (CGRP)-RAT
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $864.7
- Updated
- 2021/12/16
- Product number
- B5061
- Product name
- CGRP(rat)
- Packaging
- 100ug
- Price
- $234
- Updated
- 2021/12/16
ALPHA-CGRP (RAT) Chemical Properties,Usage,Production
Uses
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies[1][2][3][4].
in vivo
α-CGRP (mouse, rat) (0.25, 0.5, 1 μg/kg/min, intravenous) dose-dependent decreases mean arterial blood pressure, while heart rate and systemic vascular conduction increased, while cardiac output remained unchanged[3].
α-CGRP (mouse, rat) plays an important role in the regulation of Kainic acid (KA) induced pyramid-cell death in hippocampal CA3 region[4].
storage
Store at -20°C
References
[1] Whitby K, et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol. 2005 Jul;79(14):8698-706. DOI:10.1128/JVI.79.14.8698-8706.2005
[2] Xu H, et al. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9. DOI:10.1016/j.immuni.2019.09.004
[3] Arulmani U, et al. Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats. Basic Clin Pharmacol Toxicol. 2004 Jun;94(6):291-7. DOI:10.1111/j.1742-7843.2004.pto940606.x
[4] Park SH, et al. Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice. Peptides. 2013 Jun;44:158-62. DOI:10.1016/j.peptides.2013.04.001
ALPHA-CGRP (RAT) Preparation Products And Raw materials
Raw materials
Preparation Products
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