ChemicalBook > CAS DataBase List > 2-Amino-2-methyl-1-propanol

2-Amino-2-methyl-1-propanol

Product Name
2-Amino-2-methyl-1-propanol
CAS No.
124-68-5
Chemical Name
2-Amino-2-methyl-1-propanol
Synonyms
2-AMINO-2-METHYLPROPAN-1-OL;AMP-95;2-Amino-2-methylpropanol;1,1-Dimethyl-2-hydroxyethylamine;Aminomethylpropanol;2-methyl-2-amino-1-propanol;Karl Fischer;2,2-Diethyl-ethanolamine;Isobutanolamine;2-Aminoisobutanol
CBNumber
CB0320043
Molecular Formula
C4H11NO
Formula Weight
89.14
MOL File
124-68-5.mol
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2-Amino-2-methyl-1-propanol Property

Melting point:
24-28 °C (lit.)
Boiling point:
165 °C (lit.)
Density 
0.934 g/mL at 25 °C (lit.)
vapor density 
3 (vs air)
vapor pressure 
<1 mm Hg ( 25 °C)
refractive index 
n20/D 1.4455(lit.)
Flash point:
153 °F
storage temp. 
Store below +30°C.
solubility 
H2O: 0.1 M at 20 °C, clear, colorless
form 
Low Melting Solid
Specific Gravity
0.934
color 
Colorless
PH
11.0-12.0 (25℃, 0.1M in H2O)
pka
9.7(at 25℃)
PH Range
9.0 - 10.5
Odor
at 100.00?%. mild ammonia
Water Solubility 
miscible
λmax
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
Merck 
14,449
BRN 
505979
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents. May present an explosion hazard if heated.
InChIKey
CBTVGIZVANVGBH-UHFFFAOYSA-N
LogP
-0.63 at 20℃
CAS DataBase Reference
124-68-5(CAS DataBase Reference)
NIST Chemistry Reference
1-Propanol, 2-amino-2-methyl-(124-68-5)
EPA Substance Registry System
2-Amino-2-methyl-1-propanol (124-68-5)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/38-52/53
Safety Statements 
61-26
RIDADR 
2735
WGK Germany 
1
RTECS 
UA5950000
Autoignition Temperature
438 °C
Hazard Note 
Harmful/Flammable
TSCA 
Yes
PackingGroup 
III
HS Code 
29221990
Hazardous Substances Data
124-68-5(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 2900 mg/kg LD50 dermal Rabbit > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.01465
Product name
2-Amino-2-methyl-1-propanol
Purity
for synthesis
Packaging
250ML
Price
$51.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01465
Product name
2-Amino-2-methyl-1-propanol
Purity
for synthesis
Packaging
1L
Price
$95.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01465
Product name
2-Amino-2-methyl-1-propanol
Purity
for synthesis
Packaging
2.5L
Price
$224
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01465
Product name
2-Amino-2-methyl-1-propanol
Purity
for synthesis
Packaging
25L
Price
$1130
Updated
2024/03/01
Sigma-Aldrich
Product number
08578
Product name
2-Amino-2-methyl-1-propanol
Purity
BioUltra, ≥99.0% (GC)
Packaging
50ml
Price
$194
Updated
2024/03/01
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2-Amino-2-methyl-1-propanol Chemical Properties,Usage,Production

Industrial uses

Because 2-Amino-2-methyl-1-propanol has the advantages of excellent absorption and desorption capacity, high loading capacity, and low replenishment cost. AMP is one of the promising amines considered for usage in the industrial scale post-combustion CO2 capture technology[1]. At present, there are a large number of studies on the performance of 2-Amino-2-methyl-1-propanol for CO2 adsorption. Using 2-amino-2-methyl-1-propanol (AMP) as the core adsorbent and silica as the shell, the AMP microcapsules prepared are expected to replace conventional adsorbents to achieve carbon dioxide capture in cold environments[2].

Uses

2-Amino-2-methylpropanol is used for the preparation of buffer solutions, suitable for the determination of alkaline phosphatase.

Uses

2-Amino-2-methyl-1-propanol is also used in ATR-FTIR spectroscopic investigation of the carbon monoxide absorption characteristics of a series of heterocyclic diamines.

Uses

2-Amino-2-methyl-1-propanol has been used as an component in enzyme assay for screening the alkaline phosphatase activity in sarcoma osteogenic (SaOS-2) cells..

General Description

A clear light colored liquid. Insoluble in water and about the same density as water. Flash point 172°F. Used to make other chemicals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Amino-2-methyl-1-propanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Hazard

Toxic by ingestion.

Health Hazard

Causes severe irritation. Inhalation may be fatal as a result of spasm, inflammation, and edema of laryns and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting.

Fire Hazard

Special Hazards of Combustion Products: Emits toxic fumes during fire conditions.

Biochem/physiol Actions

2-Amino-2-methyl-1-propanol is a substituted aliphatic alcohol and is used majorly as a pH balancer in cosmetic formulations. It has phototoxic effect as it can interact and penetrate above the sebum layer. However, it is not carcinogenic.

Safety Profile

On March 21, 2014, the Environmental Protection Agency (EPA) issued a direct final rule with a parallel proposal identifying 2-Amino-2-methyl-1-propanol (also known as AMP) as a chemical compound that it will no longer be regulated as a volatile organic compound (VOC) under the Clean Air Act. This will remove AMP from regulatory requirements related to controlling VOC emissions in order to meet the national ambient air quality standards (NAAQS) for ozone. EPA will add AMP to the list of negligibly reactive compounds in EPA’s regulatory definition of VOC.
AMP is used for pigment dispersion in water-based coatings such as house paints. Excluding this compound from the regulatory definition of VOC, facilitates access to AMP for manufacturers of water-based coatings in order to meet VOCs limits without impairing the performance of their products or using other more toxic chemicals.

Synthesis

The synthesis of 2-Amino-2-methyl-1-propanol is as follows:

In a 1L three-neck flask with mechanical stirring, first add 200ml of water, add a few drops of dilute sulfuric acid to make it slightly acidic (pH=3.5-4), then heat to 40-50, and start adding 99.0 at the same time. 2,2-Dimethylaziridine and 400ml dilute sulfuric acid aqueous solution, keep the temperature and slightly acidic condition, drop 2,2-dimethylaziridine, then continue to react at this temperature 1h, then under reduced pressure distillation to remove 80% of the water, add 500ml ethanol to the obtained system, neutralize with 30% sodium hydroxide to pH=9.5-10, filter and remove the salt, the obtained filtrate is distilled out of ethanol under normal pressure , And then distilled under reduced pressure to obtain crude 2-amino-2-methyl-1-propanol. This crude product is then rectified to obtain 112.9g 2-amino-2-methyl-1-propanol refined product with a yield of about 91.0%, chromatographic purity is about 99.4%.

Purification Methods

Purify it by distilling and fractional freezing. The hydrochloride has m 204o-206o. [Beilstein 4 III 783, 4 IV 1740.]

References

[1] Tan W, et al. Atmospheric Chemistry of 2-Amino-2-methyl-1-propanol: A Theoretical and Experimental Study of the OH-Initiated Degradation under Simulated Atmospheric Conditions. The Journal of Physical Chemistry A, 2021; 125: 7502–7519.[2] Rama ;S, et al. Encapsulation of 2-amino-2-methyl-1-propanol with tetraethyl orthosilicate for CO2 capture. Frontiers of Chemical Science and Engineering, 2019; 13: 672–683.

2-Amino-2-methyl-1-propanol Preparation Products And Raw materials

Raw materials

Nitro formaldehyde 2-Methyl-2-nitropropan-1-ol Nickel 2-Nitropropane

Preparation Products

2,2-dimethylaziridine
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View Lastest Price from 2-Amino-2-methyl-1-propanol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Amino-2-methyl-1-propanol 124-68-5
Price
US $80.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-05-13
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
AMP 124-68-5
Price
US $60.00/KG
Min. Order
1KG
Purity
99
Supply Ability
5000
Release date
2024-05-07
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Amino-2-methyl-1-propanol 124-68-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
95%min
Supply Ability
1000KGS
Release date
2021-08-12

124-68-5, 2-Amino-2-methyl-1-propanolRelated Search:

N,N-Dimethyl-1,4-phenylenediamine DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Thiophanate-methyl Amino tris(methylene phosphonic acid) Propane Lithium bis(trimethylsilyl)amide Methyl salicylate Tris(hydroxymethyl)aminomethane METSULFURON METHYL 2-Methyl-1-propanol Isopropyl alcohol 1-Propanol Tribenuron methyl Amino-2-propanol Triisopropanolamine Kresoxim-methyl Methyl Methyl bromide

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