Diethyl aminomalonate hydrochloride
- Product Name
- Diethyl aminomalonate hydrochloride
- CAS No.
- 13433-00-6
- Chemical Name
- Diethyl aminomalonate hydrochloride
- Synonyms
- Diethyl 2-aminomalonate;DIETHYL 2-AMINOMALONATE HYDROCHLORIDE;Aminomalonamid;aminomalonate hydrochloride;diethyl 2-aminopropanedioate;AminomaL;onate HydrochL;Diethyl aminomalonat;Amoxapine Impurity 6;Amoxapine Impurity 2 HCl
- CBNumber
- CB0325376
- Molecular Formula
- C7H14ClNO4
- Formula Weight
- 211.64
- MOL File
- 13433-00-6.mol
Diethyl aminomalonate hydrochloride Property
- Melting point:
- 165-170 °C (dec.)(lit.)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform, DMSO, Water
- form
- Crystalline Powder
- color
- White to slightly yellow
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- BRN
- 3568037
- InChIKey
- GLFVNTDRBTZJIY-UHFFFAOYSA-N
- CAS DataBase Reference
- 13433-00-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D87589
- Product name
- Diethyl aminomalonate hydrochloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $39
- Updated
- 2024/03/01
- Product number
- D87589
- Product name
- Diethyl aminomalonate hydrochloride
- Purity
- 98%
- Packaging
- 10g
- Price
- $53.6
- Updated
- 2024/03/01
- Product number
- A1016
- Product name
- Diethyl Aminomalonate Hydrochloride
- Packaging
- 25g
- Price
- $16
- Updated
- 2024/03/01
- Product number
- A1016
- Product name
- Diethyl Aminomalonate Hydrochloride
- Packaging
- 100g
- Price
- $42
- Updated
- 2024/03/01
- Product number
- A13681
- Product name
- Diethyl aminomalonate hydrochloride, 98%
- Packaging
- 10g
- Price
- $30.65
- Updated
- 2024/03/01
Diethyl aminomalonate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
white to slightly yellow crystalline powder
Uses
Diethyl aminomalonate hydrochloride is used as a pharmaceutical intermediate. Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines.
Synthesis
A solution of 420.0 g of a mixture of diethyl hydroxyiminomalonate and diethyl acetoxyiminomalonate (together 2.0 mol) in 400 ml of ethyl acetate, 40.0 g of anhydrous magnesium sulfate and 12.5 g of palladium on activated charcoal (5 percent by weight of Pd) as hydrogenation catalyst were placed in a 1.5 l pressure reactor equipped with a stirrer. At 30° to 35° C., hydrogen was introduced under a pressure of 20 bar for 80 minutes until the pressure remained constant. The reactor contents were thoroughly mixed by stirring during this process. The hydrogenation mixture was cooled to 20° C. and diluted with 200 ml of ethyl acetate and the mixture of hydrous magnesium sulfate and catalyst was filtered off. The solid which had been separated off was washed three times with a total of 200 ml of ethyl acetate and the wash liquor was combined with the filtrate. Diethyl aminomalonate hydrochloride was precipitated out as a white solid by the introduction of 68 g of dry hydrogen chloride, filtered off, washed with ethyl acetate and dried under a water jet vacuum at 70° C. The yield was 359.6 g (85.1% of theory), the melting point was 165° C. and the purity according to the analytically determined chlorine content was 100%.
Diethyl aminomalonate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diethyl aminomalonate hydrochloride manufacturers
- Product
- Diethyl aminomalonate hydrochloride 13433-00-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 20KG
- Purity
- 98.5%
- Supply Ability
- 100 tons
- Release date
- 2020-07-15
- Product
- Diethyl aminomalonate hydrochloride 13433-00-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 20KG
- Purity
- 98.5%
- Supply Ability
- 100 tons
- Release date
- 2020-07-15
- Product
- Diethyl aminomalonate hydrochloride 13433-00-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 50kg/month
- Release date
- 2023-01-09