ChemicalBook > CAS DataBase List > Diethyl aminomalonate hydrochloride

Diethyl aminomalonate hydrochloride

Product Name
Diethyl aminomalonate hydrochloride
CAS No.
13433-00-6
Chemical Name
Diethyl aminomalonate hydrochloride
Synonyms
Diethyl 2-aminomalonate;DIETHYL 2-AMINOMALONATE HYDROCHLORIDE;Aminomalonamid;aminomalonate hydrochloride;diethyl 2-aminopropanedioate;AminomaL;onate HydrochL;Diethyl aminomalonat;Amoxapine Impurity 6;Amoxapine Impurity 2 HCl
CBNumber
CB0325376
Molecular Formula
C7H14ClNO4
Formula Weight
211.64
MOL File
13433-00-6.mol
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Diethyl aminomalonate hydrochloride Property

Melting point:
165-170 °C (dec.)(lit.)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform, DMSO, Water
form 
Crystalline Powder
color 
White to slightly yellow
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
3568037
InChIKey
GLFVNTDRBTZJIY-UHFFFAOYSA-N
CAS DataBase Reference
13433-00-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29224995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D87589
Product name
Diethyl aminomalonate hydrochloride
Purity
98%
Packaging
25g
Price
$39
Updated
2024/03/01
Sigma-Aldrich
Product number
D87589
Product name
Diethyl aminomalonate hydrochloride
Purity
98%
Packaging
10g
Price
$53.6
Updated
2024/03/01
TCI Chemical
Product number
A1016
Product name
Diethyl Aminomalonate Hydrochloride
Packaging
25g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
A1016
Product name
Diethyl Aminomalonate Hydrochloride
Packaging
100g
Price
$42
Updated
2024/03/01
Alfa Aesar
Product number
A13681
Product name
Diethyl aminomalonate hydrochloride, 98%
Packaging
10g
Price
$30.65
Updated
2024/03/01
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Diethyl aminomalonate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to slightly yellow crystalline powder

Uses

Diethyl aminomalonate hydrochloride is used as a pharmaceutical intermediate. Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines.

Synthesis

A solution of 420.0 g of a mixture of diethyl hydroxyiminomalonate and diethyl acetoxyiminomalonate (together 2.0 mol) in 400 ml of ethyl acetate, 40.0 g of anhydrous magnesium sulfate and 12.5 g of palladium on activated charcoal (5 percent by weight of Pd) as hydrogenation catalyst were placed in a 1.5 l pressure reactor equipped with a stirrer. At 30° to 35° C., hydrogen was introduced under a pressure of 20 bar for 80 minutes until the pressure remained constant. The reactor contents were thoroughly mixed by stirring during this process. The hydrogenation mixture was cooled to 20° C. and diluted with 200 ml of ethyl acetate and the mixture of hydrous magnesium sulfate and catalyst was filtered off. The solid which had been separated off was washed three times with a total of 200 ml of ethyl acetate and the wash liquor was combined with the filtrate. Diethyl aminomalonate hydrochloride was precipitated out as a white solid by the introduction of 68 g of dry hydrogen chloride, filtered off, washed with ethyl acetate and dried under a water jet vacuum at 70° C. The yield was 359.6 g (85.1% of theory), the melting point was 165° C. and the purity according to the analytically determined chlorine content was 100%.

Diethyl aminomalonate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Diethyl aminomalonate hydrochloride manufacturers

Changde Changlian Chemical Co., Ltd.
Product
Diethyl aminomalonate hydrochloride 13433-00-6
Price
US $0.00/Kg/Drum
Min. Order
20KG
Purity
98.5%
Supply Ability
100 tons
Release date
2020-07-15
Ningxia Jinhua Chemical Co.,Ltd
Product
Diethyl aminomalonate hydrochloride 13433-00-6
Price
US $0.00/Kg/Drum
Min. Order
20KG
Purity
98.5%
Supply Ability
100 tons
Release date
2020-07-15
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
Diethyl aminomalonate hydrochloride 13433-00-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2025-01-09

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