Flomoxef

ChemicalBook > CAS DataBase List > Flomoxef

Product Name: Flomoxef
CAS No.: 99665-00-6
Chemical Name: Flomoxef
Synonyms: FMOX;Flumarin;FLOMOXEF;FLOMOEXF;Flomoxef Acid;Flomoxef Monomer;Flomoxef USP/EP/BP;Flomoxef Acid(Sodium);8-Pyridinecarboxamide,N-phenyl-;Flomoxef Sodium、Flumarin、Sodium Flomoxef
CBNumber: CB0328847
Molecular Formula: C15H18F2N6O7S2
Formula Weight: 496.47
MOL File: 99665-00-6.mol

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Flomoxef Property

Melting point:: 82.5-87.5°
Density: 1.85±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: soluble in DMSO, Methanol
form: Solid
pka: 3.26±0.40(Predicted)
color: Off-White
CAS DataBase Reference: 99665-00-6(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: F401850
Product name: Flomoxef
Packaging: 1.0mg
Price: $630
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007274
Product name: FLOMOXEF
Purity: 95.00%
Packaging: 0.5MG
Price: $636
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007274
Product name: FLOMOXEF
Purity: 95.00%
Packaging: 1G
Price: $1686.3
Updated: 2021/12/16

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Flomoxef Chemical Properties,Usage,Production

Description

Flomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.

Originator

Shionogi (Japan)

Uses

Flomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.

Definition

ChEBI: Flomoxef is a second-generation oxacephem antibiotic in which the oxazine ring is substituted at C-3 with a hydroxyethyl-substituted tetrazolylthiomethyl group and the azetidinone ring carries 7alpha-methoxy and 7beta-{2-[(difluoromethyl)thiomethyl]acetamido} substituents. It has a role as an antibacterial drug. It is a N-acyl-amino acid, an oxacephem and an organonitrogen heterocyclic antibiotic.

brand name

Flumari

Antimicrobial activity

An oxa-cephem which differs from latamoxef in the side chains carried at the 7-amino and C-3 positions, but which retains the 7-methoxy group that confers β-lactamase stability. The methyl group of the methylthiotetrazole side chain of latamoxef has been modified to hydroxymethyl in an attempt to avoid the undesirable side effects, while the side chain at the 7-amino position is F2-CH-S-CH2-.
Activity is similar to that of latamoxef, but activity against Staph. aureus is improved and it is claimed to be a poor inducer of penicillin-binding protein 2′, which is associated with resistance in methicillin-resistant strains.
Intravenous injection of 2 g achieves a peak plasma concentration of around 50 mg/L, falling to 2.6 mg/L after 6 h. The plasma half-life is about 50 min. It appears to be well distributed and penetrates moderately well into lung, mucosal tissue of the middle ear and bone.
Flomoxef does not seem to be prone to the effects on platelet function of latamoxef and it has a less marked effect on vitamin K metabolism. It does not cause a disulfiram-like reaction with alcohol.
It is available in Japan, where it appears safe and effective in a wide range of infections.

Flomoxef Preparation Products And Raw materials

Raw materials

Ethyl Thioglycolate Ethanol Potassium hydroxide Sodium chloride Triethylamine Sodium ethoxide Magnesium sulfate Iodomethane

Preparation Products

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View Lastest Price from Flomoxef manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Flomoxef 99665-00-6
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-11-05

Hebei Yanxi Chemical Co., Ltd.

Product: Flomoxef 99665-00-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 20tons
Release date: 2023-10-24

Zhuozhou Wenxi import and Export Co., Ltd

Product: Flomoxef 99665-00-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

99665-00-6, FlomoxefRelated Search:

5-Chlorovaleric acid Pralmorelin N-Acetylsulfanilyl chloride Flomoxef sodium salt,Flomoxef sodium 2-(METHYLSULFONYL)ETHANOL 4-(Diethylamino)salicylaldehyde Diphenolic acid DL-α-Tocopherol Acetaminophen 2-HYDROXYETHYL N-PENTYL SULPHIDE, 95 3-AZETIDINOL 2-(5-Mercaptotetrazole-1-yl)ethanol 1-Ethyl-1H-1,2,3,4-tetrazole-5-thiol 1-METHYL-3-AZETIDINOL 3-METHOXY-AZETIDINE Flomoxef ACETAMINOPHENOL BP/USP Flomoxef Jp13

FLOMOXEF

5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)-

FLOMOXEF [5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)- ]

5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, (6R,7R)-

Flumarin

FMOX

(-)-(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

[6R,7R,(-)]-7α-[[2-(Difluoromethylthio)acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-[(difluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-,(6R,7R)-

(6R,7R)-7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

(6R-cis)7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

(6R-cis)-7-[[[(Difluoromethyl)thio]acetyl]amino]-3_[[[1-(2-hy-droxyethyl)-1H-tetrazol-5-y1]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-[[2-(difluoromethylsulfanyl)acetyl]amino]-3-[[1-(2-hydroxyethyl)tetrazol-5-yl]sulfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-[[2-(difluoromethylthio)-1-oxoethyl]amino]-3-[[[1-(2-hydroxyethyl)-5-tetrazolyl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Flomoxef Sodium、Flumarin、Sodium Flomoxef

Flomoxef USP/EP/BP

FLOMOEXF

Flomoxef Acid

8-Pyridinecarboxamide,N-phenyl-

Flomoxef Monomer

Flomoxef Acid(Sodium)

99665-00-6

C15H18F2N6O7S2

C15H18N6O7F2S2

Heterocycles

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