ChemicalBook > CAS DataBase List > Flomoxef

Flomoxef

Product Name
Flomoxef
CAS No.
99665-00-6
Chemical Name
Flomoxef
Synonyms
FMOX;Flumarin;FLOMOXEF;FLOMOEXF;Flomoxef Acid;Flomoxef Monomer;Flomoxef USP/EP/BP;8-Pyridinecarboxamide,N-phenyl-;Flomoxef Sodium、Flumarin、Sodium Flomoxef;(6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CBNumber
CB0328847
Molecular Formula
C15H18F2N6O7S2
Formula Weight
496.47
MOL File
99665-00-6.mol
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Flomoxef Property

Melting point:
82.5-87.5°
Density 
1.85±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
soluble in DMSO, Methanol
form 
Solid
pka
3.26±0.40(Predicted)
color 
Off-White
CAS DataBase Reference
99665-00-6(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
F401850
Product name
Flomoxef
Packaging
1.0mg
Price
$630
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007274
Product name
FLOMOXEF
Purity
95.00%
Packaging
0.5MG
Price
$636
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007274
Product name
FLOMOXEF
Purity
95.00%
Packaging
1G
Price
$1686.3
Updated
2021/12/16
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Flomoxef Chemical Properties,Usage,Production

Description

Flomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.

Originator

Shionogi (Japan)

Uses

Flomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.

Definition

ChEBI: Flomoxef is a second-generation oxacephem antibiotic in which the oxazine ring is substituted at C-3 with a hydroxyethyl-substituted tetrazolylthiomethyl group and the azetidinone ring carries 7alpha-methoxy and 7beta-{2-[(difluoromethyl)thiomethyl]acetamido} substituents. It has a role as an antibacterial drug. It is a N-acyl-amino acid, an oxacephem and an organonitrogen heterocyclic antibiotic.

brand name

Flumari

Antimicrobial activity

An oxa-cephem which differs from latamoxef in the side chains carried at the 7-amino and C-3 positions, but which retains the 7-methoxy group that confers β-lactamase stability. The methyl group of the methylthiotetrazole side chain of latamoxef has been modified to hydroxymethyl in an attempt to avoid the undesirable side effects, while the side chain at the 7-amino position is F2-CH-S-CH2-.
Activity is similar to that of latamoxef, but activity against Staph. aureus is improved and it is claimed to be a poor inducer of penicillin-binding protein 2′, which is associated with resistance in methicillin-resistant strains.
Intravenous injection of 2 g achieves a peak plasma concentration of around 50 mg/L, falling to 2.6 mg/L after 6 h. The plasma half-life is about 50 min. It appears to be well distributed and penetrates moderately well into lung, mucosal tissue of the middle ear and bone.
Flomoxef does not seem to be prone to the effects on platelet function of latamoxef and it has a less marked effect on vitamin K metabolism. It does not cause a disulfiram-like reaction with alcohol.
It is available in Japan, where it appears safe and effective in a wide range of infections.

Flomoxef Preparation Products And Raw materials

Raw materials

ETHYL THIOGLYCOLATE Ethanol Potassium hydroxide Sodium chloride Triethylamine Sodium ethoxide Magnesium sulfate Iodomethane

Preparation Products

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View Lastest Price from Flomoxef manufacturers

Hebei Duling International Trade Co. LTD
Product
Flomoxef 99665-00-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
300MT/month
Release date
2022-11-22
Hebei Yanxi Chemical Co., Ltd.
Product
Flomoxef 99665-00-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
20tons
Release date
2023-10-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Flomoxef 99665-00-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-11-05

99665-00-6, FlomoxefRelated Search:

5-Chlorovaleric acid Pralmorelin N-Acetylsulfanilyl chloride Flomoxef sodium salt,Flomoxef sodium 2-(METHYLSULFONYL)ETHANOL 4-(Diethylamino)salicylaldehyde Diphenolic acid DL-α-Tocopherol Acetaminophen 2-HYDROXYETHYL N-PENTYL SULPHIDE, 95 3-AZETIDINOL 2-(5-Mercaptotetrazole-1-yl)ethanol 1-Ethyl-1H-1,2,3,4-tetrazole-5-thiol 1-METHYL-3-AZETIDINOL 3-METHOXY-AZETIDINE Flomoxef ACETAMINOPHENOL BP/USP Flomoxef Jp13

  • FLOMOXEF
  • 5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)-
  • FLOMOXEF [5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)- ]
  • 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, (6R,7R)-
  • Flumarin
  • FMOX
  • (-)-(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • [6R,7R,(-)]-7α-[[2-(Difluoromethylthio)acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-[(difluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-,(6R,7R)-
  • (6R,7R)-7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • (6R-cis)7-[[[(DifluoroMethyl)thio]acetyl]aMino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]Methyl]-7-Methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • (6R-cis)-7-[[[(Difluoromethyl)thio]acetyl]amino]-3_[[[1-(2-hy-droxyethyl)-1H-tetrazol-5-y1]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7-[[2-(difluoromethylsulfanyl)acetyl]amino]-3-[[1-(2-hydroxyethyl)tetrazol-5-yl]sulfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7-[[2-(difluoromethylthio)-1-oxoethyl]amino]-3-[[[1-(2-hydroxyethyl)-5-tetrazolyl]thio]methyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Flomoxef Sodium、Flumarin、Sodium Flomoxef
  • Flomoxef USP/EP/BP
  • FLOMOEXF
  • Flomoxef Acid
  • 8-Pyridinecarboxamide,N-phenyl-
  • Flomoxef Monomer
  • 99665-00-6
  • C15H18F2N6O7S2
  • C15H18N6O7F2S2
  • Heterocycles
  • Intermediates & Fine Chemicals
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