Ciprofibrate

ChemicalBook > CAS DataBase List > Ciprofibrate

Product Name: Ciprofibrate
CAS No.: 52214-84-3
Chemical Name: Ciprofibrate
Synonyms: Ciprofibric acid;Cipml;Ciprol;Modalim;Lipanor;Win-35833;Ciprobrate;CIPROFIBRATE;Ciprofibrate >Ciprofibrate CRS
CBNumber: CB0329743
Molecular Formula: C13H14Cl2O3
Formula Weight: 289.15
MOL File: 52214-84-3.mol

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Ciprofibrate Property

Melting point:: 114-116°
Boiling point:: 401.74°C (rough estimate)
Density: 1.2576 (rough estimate)
refractive index: 1.5209 (estimate)
storage temp.: 2-8°C
solubility: Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in toluene.
pka: 3.31±0.10(Predicted)
color: White to Pale Beige
Merck: 14,2313
InChIKey: KPSRODZRAIWAKH-UHFFFAOYSA-N
CAS DataBase Reference: 52214-84-3(CAS DataBase Reference)
EPA Substance Registry System: Propanoic acid, 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl- (52214-84-3)

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Safety

Hazard Codes: T
Risk Statements: 45
Safety Statements: 53-22-36/37/39-45
WGK Germany: 3
RTECS: UF0880000
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C0330
Product name: Ciprofibrate
Packaging: 10mg
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: C2667
Product name: Ciprofibrate
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $178
Updated: 2024/03/01

TCI Chemical

Product number: C2667
Product name: Ciprofibrate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $445
Updated: 2024/03/01

Cayman Chemical

Product number: 18515
Product name: Ciprofibrate
Purity: ≥98%
Packaging: 1g
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 18515
Product name: Ciprofibrate
Purity: ≥98%
Packaging: 5g
Price: $161
Updated: 2024/03/01

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Ciprofibrate Chemical Properties,Usage,Production

Description

Ciprofibrate is a potent, long-acting hypolipidemic agent related to clofibrate, bezafibrate and fenofibrate. It is effective in types IIa, IIb, IIX and IV hyperlipoproteinemias, and produces a beneficial elevation of the anti-atherogenic HDL.

Description

Ciprofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC₅₀ = 0.9 μM in a transactivation assay). It is selective for PPARα over PPARγ and PPARδ at 300 μM. Ciprofibrate (250 μM) induces cell cycle arrest at the G₂/M and S phases in Fao rat, but not HepG2 human, hepatocellular carcinoma cells. It decreases fasting plasma levels of triglycerides and increases fasting plasma glucose levels in the apolipoprotein CIII transgenic mouse model of hypertriglyceridemia when administered at a dose of 10 mg/kg. Formulations containing ciprofibrate have been used in the treatment of hypertriglyceridemia.

Chemical Properties

Off-White to Pale Beige Solid

Originator

Sterling-Wintbrop (USA)

Uses

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. Ciprofibrate activates PPARα with an EC50 value of 20 μM and only marginally affects PPARγ (EC50 = >300 μM). It has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rats and has been used clinically in the treatment of dyslipidemia. Ciprofibrate reportedly stimulates cholesteryl ester transfer protein expression and improves the flow of cholesterol through the indirect reverse cholesterol transport system, preserving plasma HDL.

Uses

antihyperlipidemic

Uses

Ciprofibrate is a hypolipemic agent, related structurally to Clofibrate (C586910). Ciprofibrate is used as an antilipemic.

Definition

ChEBI: Ciprofibrate is a monocarboxylic acid, a member of cyclopropanes and an organochlorine compound. It has a role as an antilipemic drug.

Manufacturing Process

A mixture of 8 g (0.0356 mol) of p-(2,2-dichlorocyclopropyl)phenol, 11.2 g (0.28 mol) of sodium hydroxide pellets, 11 g of chloroform and 350 ml of acetone was prepared at 0°C. The cooling bath was removed, the mixture stirred for a minute and then heated on a steam bath to reflux temperature. The reaction mixture was stirred at reflux for three hours and then concentrated in vacuo. The residual gum was partitioned between dilutehydrochloric acid and ether, and the ether layer was separated, dried and concentrated in vacuo. The residual oil (14 g) was partitioned between dilute aqueous sodium bicarbonate and ether. The sodium bicarbonate solution was acidified with concentrated hydrochloric acid and extracted with ether. The ether solution was dried over anhydrous sodium sulfate and concentrated. The residue (9.5 g of yellow oil) was crystallized twice from hexane to give 6.0 g of 2-[p-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl propionic acid in the form of a pale cream-colored solid, MP 114°C to 116°C.

brand name

LJPANOR

Therapeutic Function

Antihyperlipidemic

World Health Organization (WHO)

The safety profile of ciprofibrate is similar to that of clofibrate. See also under clofibrate in full edition.

Biochem/physiol Actions

Peroxisome proliferator-activated receptor α (PPARα) agonist

Clinical Use

Hyperlipidaemia

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: increased risk of myopathy with daptomycin - try to avoid concomitant use.
Anticoagulants: enhances effect of coumarins and phenindione. Dose of anticoagulant should be reduced by up to 50% and readjusted by monitoring INR.
Antidiabetics: may improve glucose tolerance and have an additive effect with insulin or sulphonylureas.
Colchicine: possible increased risk of myopathy.
Lipid-regulating drugs: increased risk of myopathy in combination with statins and ezetimibe (Do not exceed 10 mg of simvastatin and 20 mg of rosuvastatin.1 ) - avoid with ezetimibe.

Metabolism

Approximately 30-75% of a single dose administered to volunteers was excreted in the urine in 72 hours, either as unchanged ciprofibrate (20-25% of the total excreted) or as a glucuronide conjugate. Subjects with moderate renal impairment excreted on average 7% of a single dose as unchanged ciprofibrate over 96 hours, compared with 6.9% in normal subjects. In subjects with severe insufficiency this was reduced to 4.7%.

Ciprofibrate Preparation Products And Raw materials

Raw materials

4-Propylphenol Solid sodium hydroxide BUTTER

Preparation Products

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View Lastest Price from Ciprofibrate manufacturers

Hebei Duling International Trade Co. LTD

Product: Ciprofibrate 52214-84-3
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Ton
Release date: 2023-03-20

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ciprofibrate 52214-84-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%-101%;EP
Supply Ability: 1000KGS
Release date: 2021-06-28

Hebei Guanlang Biotechnology Co,.LTD

Product: Ciprofibrate 52214-84-3
Price: US $1.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2021-08-25

52214-84-3, CiprofibrateRelated Search:

Cyromazine Ciprofloxacin hydrochloride Propiconazole Ciprofloxacin lactate Ciprofloxacin 2,2-Bis(hydroxymethyl)propionic acid 3-Mercaptopropyltriethoxysilane Dichlorodimethylsilane 3-Chloropropyltrimethoxysilane Methyltriethoxysilane 2-Chloro-5-chloromethylpyridine Methyltrimethoxysilane Trimethoxypropylsilane (2,2-Dichlorocyclopropyl)benzene 1-(2-CHLOROETHYL)-4-METHOXYBENZENE CYCLOPROPYLBENZENE 4-ISOPROPYLPHENOXYACETIC ACID 2-(4-ISOPROPYLPHENOXY)-2-METHYLPROPANOIC ACID

2-[4-(2，2-Dichlom-cyclopropyl)phenoxy]-2-methy|propanoic acid

Cipml

Lipanor

Modalim

Win-35833

2-(p-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropionicacid

2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropionic acid

Ciprofibric acid

Ciprol

Ciprofibrate,2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Ciprobrate

CIPROL;LIPANOR;MODALIM;WIN35833

Ciprofibrate, >98.0%(GC)

2-[P-(2,2-DICHLOROCYCLOPROPYL)-PHENOXY]-2-METHYLPROPANOIC ACID

CIPROFIBRATE

2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methyl-propanoicaci

2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methyl-propionicaci

Ciprofibrate, 99%, a PPAR α agonist

Ciprofibrate &gt

Ciprofibrate CRS

Ciprofibrate for system suitability CRS

Propanoic acid, 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl-

Ciprofibrate USP/EP/BP

CiprofibrateQ: What is Ciprofibrate Q: What is the CAS Number of Ciprofibrate Q: What is the storage condition of Ciprofibrate Q: What are the applications of Ciprofibrate

Ciprofibrate/2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid

2-[4-[(1RS)-2,2-dichlorocyclopropyl]phenoxy]-2-methylpropanoicacid

Ciprofibrate Ciprofibrate(API)

Ciprofibrate Impurity

Ciprofibrate, ≥ 98.0%

52214-84-3

C13H14Cl2O3

Gene Regulation and Expression

PPAR and RXR Regulators

Cell Signaling and Neuroscience

Cell Biology

BioChemical

API

Intracellular receptor