ANGIOTENSIN II, HUMAN
Discovery Structure Gene, mRNA, and mRNA Agonist Antagonist Biological functions- Product Name
- ANGIOTENSIN II, HUMAN
- CAS No.
- 4474-91-3
- Chemical Name
- ANGIOTENSIN II, HUMAN
- Synonyms
- ANGIOTENSIN II;Ang II;DRVYIHPF;TY-10721;AngiotensinⅡ;ANGIOTENSIN-2;H-DRVYIHPF-OH;angiotensin renin;ANTI-ANGIOTENSIN II;ile(5)-angiotensini
- CBNumber
- CB0338057
- Molecular Formula
- C50H71N13O12
- Formula Weight
- 1046.2
- MOL File
- 4474-91-3.mol
ANGIOTENSIN II, HUMAN Property
- Boiling point:
- 809.08°C (rough estimate)
- Density
- 1.1257 (rough estimate)
- refractive index
- 1.6700 (estimate)
- RTECS
- BW2165000
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- insoluble in DMSO; insoluble in EtOH; ≥100.2 mg/mL in H2O
- form
- Powder
- pka
- pK1: 10.37 (25°C)
- color
- orange
- biological source
- human
- Water Solubility
- Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).
- Sequence
- H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
- Stability:
- Hygroscopic
- InChI
- InChI=1/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/s3
- InChIKey
- CZGUSIXMZVURDU-JZXHSEFVSA-N
- SMILES
- C(N1CCC[C@H]1C(=O)N[C@H](C(=O)O)CC1C=CC=CC=1)(=O)[C@@H](NC(=O)[C@]([H])([C@@H](C)CC)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(=O)O)CC1C=CC(O)=CC=1)CC1N=CNC=1 |&1:5,9,21,25,27,34,38,45,56,r|
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A9525
- Product name
- Angiotensin II human
- Purity
- ≥93% (HPLC), powder
- Packaging
- 1mg
- Price
- $38.4
- Updated
- 2024/03/01
- Product number
- A9525
- Product name
- Angiotensin II human
- Purity
- ≥93% (HPLC), powder
- Packaging
- 5x1mg
- Price
- $154
- Updated
- 2024/03/01
- Product number
- A9525
- Product name
- Angiotensin II human
- Purity
- ≥93% (HPLC), powder
- Packaging
- 25MG
- Price
- $308
- Updated
- 2024/03/01
- Product number
- 05-23-0101
- Product name
- Angiotensin II, Human - CAS 4474-91-3 - Calbiochem
- Purity
- Plays an important role in the regulation of blood pressure.
- Packaging
- 1mg
- Price
- $57.8
- Updated
- 2024/03/01
- Product number
- 05-23-0101
- Product name
- Angiotensin II, Human - CAS 4474-91-3 - Calbiochem
- Purity
- Plays an important role in the regulation of blood pressure.
- Packaging
- 5mg
- Price
- $72.8
- Updated
- 2024/03/01
ANGIOTENSIN II, HUMAN Chemical Properties,Usage,Production
Discovery
Angiotensin II is the active peptide hormone of the reninangiotensin system (RAS) with broad functions, including a vasopressor effect and thirst stimulation. It is a drug target for hypertension and renal diseases. In 1940, two groups of researchers separately discovered a potent vasoconstrictor by incubating plasma with renin; the substance was named both “angiotonin” and “hypertensin.” In 1958, they agreed to rename it “angiotensin” (angio=blood vessel; tensin=tension).
Structure
Ang II is a linear peptide with no known secondary modification. Ang II is produced by the subsequent cleavage of angiotensinogen (AGT) by renin and angiotensin I (Ang I) by ACE (See Renin Angiotensin System). Mr. 1046 of Ang II in humans. Freely soluble in water.
Gene, mRNA, and mRNA
AGT is located on chromosome 1q42.2 in humans. AGT belongs to the SERPIN family A, member 8. AGT protein sequences are highly variable but the functional domains (Ang I) are relatively conserved among vertebrates. Ang I sequences were identified by the incubation of a renin source (kidney extract) and an angiotensinogen source (plasma). Lamprey Ang I with sequence NRVYVHPFTL was first sequenced using peptide purification. However, the lamprey genome data suggested a different Ang I sequence, and was later confirmed as the native AGT. The purified teleost-type Ang I produced in the buccal gland was suggested to be involved in endocrine mimicry to reduce host immunorejection.
Agonist
A nonpeptide ligand, L-162,313 was shown to bind to AT1A, AT1B, and the AT2 receptor and act as an agonist on AT1A and AT1B receptors in mice (34.9 and 23.3% of the maximum response of Ang II, respectively). Early studies used CGP42112A as the agonist for the AT2 receptor but compound 21, with little affinity for the AT1 receptor, was recently developed as a specific agonist of the AT2 receptor in humans.
Antagonist
Saralasin ([Sar1 ], [Ala8 ]-Ang II) is a partial agonist of angiotensin II receptors, though it is commonly mistaken as a competitive antagonist. Antagonists including losartan, irbesartan, olmesartan, candesartan, and valsartan are commonly used clinically as AT1 blockers. Two AT2 receptor antagonists, PD123177 (discontinued) and PD123319 (available), were developed to inhibit AT2 activities.
Biological functions
Ang II/AT1 axis mediates vasoconstriction, thirst,
release of vasopressin and aldosterone, renal sodium
reabsorption, fibrosis, inflammation, angiogenesis, vascular aging, and atherosclerosis. Ang II-induced effects
included blood pressure control; drinking; adrenergic
stimulation; modulation of the ion pump and transporter
activities in the gill, kidney, and intestine in fish; control
of the filtering nephron population in fish; and regulation of ventral skin absorption in amphibians. The injection of Ang II significantly increased ventral skin
drinking in the frog. Lamprey Ang II is a vasodepressor
instead of a vasopressor when injected intraarterially. The intracerebroventricular (ICV) injection of Ang II into
the trout increased the systemic blood pressure, heart
rate, and ventilation rate. The ICV injection of Ang II
elicits tachycardia in contrast to bradycardia when
injected peripherally. Central Ang II injection also
inhibits the vagal-mediated baro-reflex, indicating that
brain RAS is involved in the heart rate control.
The AT2 receptor is mostly embryonic. The expression
decreases in adults and is confined in certain tissues such
as the kidney. The effects of AT2 are often antagonistic to
AT1, and activation of the AT2 receptor usually indicates
a pathophysiological condition of AT1-mediated action
with potential harmful consequences. AT2 is abundantly
expressed in the spleen of the adult eel, which suggests an
immune-related function.
Description
It is known that tumor tissues including metastatic lymph nodes are composed of newly growing vessels which lack blood flow autoregulation and are influenced only secondarily by the responding somatic vessels. Human angiotensin II (AT II). a vasopressor, was introduced in Japan to improve the efficacy of systemic chemotherapy. In patients with various advanced cancers, i.v. infusion of AT II to achieve a mean blood pressure of 1.5 times of baseline (but not over 150 mm Hg) followed by a bolus injection of conventional cytotoxic agents increases blood flow 5-7 fold in tumor tissues and therefore, increases drug delivery to the target tissue resulting in enhanced chemotherapeutic effects. This induced-hypertension chemotherapy regimen can be performed safely with minimal side effects.
Description
Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct signaling pathways and physiological responses. The development of antagonists for specific angiotensin II receptor subtypes represents a valuable alternative to ACE inhibitors.
Originator
Toa Eiyo (Japan)
Uses
A peptide involved in the regulation of blood pressure
Uses
Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct signaling pathways and physiological responses. The development of antagonists for specific angiotensin II receptor subtypes represents a valuable alternative to ACE inhibitors.
Uses
Cardiopulmonary resuscitation - not yet an approved application
Definition
ChEBI: Ile(5)-angiotensin II is an angiotensin II that acts on the central nervous system (PDB entry: 1N9V). It has a role as a human metabolite. It is a tautomer of an Ile(5)-angiotensin II dizwitterion.
brand name
Delivert
General Description
Functions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.
Biochem/physiol Actions
Product does not compete with ATP.
Clinical Use
Renin antagonists, ACE inhibitors, and AT1 receptor blockers have been used, in singular or multiple blockade, to treat hypertension and other RAS-related diseases. High levels of Ang II are often related to hypertension, renal failure, and cardiac fibrosis.
in vitro
Most of the known actions of Angiotensin II (Ang II) are mediated by AT 1 receptors, the AT 2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT 1 ). At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT 1 and AT 2 ). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors.
in vivo
To distinguish the AT 1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT 1 receptors in the kidney promoting sodium reabsorption.
storage
-20°C (desiccate)
ANGIOTENSIN II, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
ANGIOTENSIN II, HUMAN Suppliers
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- 400-6206333 18021050169
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18738
- Advantage
- 57
- Tel
- 27-027-83314682 13554138826
- Fax
- +86 (27) 8331-4682
- whsrtech@vip.163.com
- Country
- China
- ProdList
- 154
- Advantage
- 62
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4940
- Advantage
- 60
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 400-6206333 18021050169
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9545
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 021-61119791,13386096464
- Fax
- 021-50190009
- bzswkf@foxmail.com
- Country
- China
- ProdList
- 3921
- Advantage
- 50
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3466
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 755-755-26612112 15013529272;
- Fax
- +86 (755) 8635-0488
- jymed@jymedtech.com
- Country
- China
- ProdList
- 81
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9648
- Advantage
- 58
- Tel
- 400-6087598 15021221957
- Fax
- 4006087598-8012
- order@canspecsci.com
- Country
- China
- ProdList
- 2045
- Advantage
- 56
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 16166
- Advantage
- 55
- Tel
- 0571-89197072; 18668118770
- Fax
- 0571-89197072
- linda@peptide-china.com
- Country
- China
- ProdList
- 248
- Advantage
- 56
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 027-86652399 13627115097;
- Fax
- 86-27-59707018
- sales@senwayer.com
- Country
- China
- ProdList
- 267
- Advantage
- 55
- Tel
- +86 (27) 8778653
- Fax
- +86 (27) 8773-8652
- 13720228325@163.com
- Country
- China
- ProdList
- 337
- Advantage
- 58
- Tel
- 4000-819-385 010-62329685 13718666987
- Fax
- 010-62340519
- Country
- China
- ProdList
- 1971
- Advantage
- 55
- Tel
- 18620099427 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 1751
- Advantage
- 55
- Tel
- 17802107445
- Country
- China
- ProdList
- 185
- Advantage
- 55
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20806
- Advantage
- 60
- Tel
- 18221735425
- sales@xinpingchem.com
- Country
- China
- ProdList
- 9942
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 7312
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29764
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13320
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 17705183659
- Fax
- 84523390
- sales@njleonbiotech.com
- Country
- China
- ProdList
- 5501
- Advantage
- 55
- Tel
- 025-025-58361106-805-805 13082558573
- Fax
- 025-58361106-806
- liugang@njpeptide.com
- Country
- China
- ProdList
- 9980
- Advantage
- 55
- Tel
- 027-65526929 15102793023
- Fax
- 027-65526669
- hbhxry@foxmail.com
- Country
- China
- ProdList
- 2006
- Advantage
- 55
- Tel
- 020-84383047
- Fax
- 020-84380294
- sales@jhd.com.cn
- Country
- China
- ProdList
- 9186
- Advantage
- 65
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28805
- Advantage
- 58
- Tel
- +86-17380623303 +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4809
- Advantage
- 58
- Tel
- 021-37581181
- Fax
- 021-57456066
- sales@chem-mall.com
- Country
- China
- ProdList
- 10330
- Advantage
- 58
- Tel
- 021-60257269 18601606476
- Fax
- +86-21-60253672
- yl@mkpharma.cn
- Country
- China
- ProdList
- 206
- Advantage
- 58
- Tel
- 025-66113011 18112977050
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 15497
- Advantage
- 58
View Lastest Price from ANGIOTENSIN II, HUMAN manufacturers
- Product
- ANGIOTENSIN II, HUMAN 4474-91-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-01
- Product
- Angiotensin II 4474-91-3
- Price
- US $0.00-0.00/BOX
- Min. Order
- 1BOX
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-11-12
- Product
- Angiotensin Ⅱ, human 4474-91-3
- Price
- US $0.00-0.00/BOX
- Min. Order
- 1BOX
- Purity
- 99%
- Supply Ability
- 20Ton
- Release date
- 2024-10-30