8-Aminooctanoic acid

Product Name: 8-Aminooctanoic acid
CAS No.: 1002-57-9
Chemical Name: 8-Aminooctanoic acid
Synonyms: 8-AMINOCAPRYLIC ACID;H-AOC(8)-OH;NH2-(CH2)7-COOH;8-Aminooctanoic;8-aMino bitterness;8-Amino-octyl acid;TIMTEC-BB SBB006735;RARECHEM EM WB 0024;8-AMINOOCTANOIC ACID;w-Aminocaprylic acid
CBNumber: CB0346319
Molecular Formula: C8H17NO2
Formula Weight: 159.23
MOL File: 1002-57-9.mol

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8-Aminooctanoic acid Property

Melting point:: 194 °C (dec.) (lit.)
Boiling point:: 286.0±23.0 °C(Predicted)
Density: 1.0500 (estimate)
refractive index: 1.4630 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Methanol (Very Slightly), Water (Slightly)
pka: 4.76±0.10(Predicted)
form: Crystalline Powder
color: White to slightly beige
Water Solubility: Soluble in water.
BRN: 1756493
InChI: InChI=1S/C8H17NO2/c9-7-5-3-1-2-4-6-8(10)11/h1-7,9H2,(H,10,11)
InChIKey: UQXNEWQGGVUVQA-UHFFFAOYSA-N
SMILES: C(O)(=O)CCCCCCCN
CAS DataBase Reference: 1002-57-9(CAS DataBase Reference)
NIST Chemistry Reference: 8-Aminocaprylic acid(1002-57-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-37/39-26
WGK Germany: 3
HS Code: 29224985

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 855294
Product name: 8-Aminooctanoic acid
Purity: 99%
Packaging: 1g
Price: $76.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 855294
Product name: 8-Aminooctanoic acid
Purity: 99%
Packaging: 5g
Price: $204
Updated: 2024/03/01

Alfa Aesar

Product number: A17353
Product name: 8-Aminooctanoic acid, 99%
Packaging: 1g
Price: $50.65
Updated: 2024/03/01

Alfa Aesar

Product number: A17353
Product name: 8-Aminooctanoic acid, 99%
Packaging: 5g
Price: $203
Updated: 2024/03/01

TRC

Product number: A581520
Product name: 8-Aminooctanoic acid
Packaging: 10g
Price: $345
Updated: 2021/12/16

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8-Aminooctanoic acid Chemical Properties,Usage,Production

Chemical Properties

WHITE TO SLIGHTLY BEIGE CRYSTALLINE POWDER

Uses

8-Aminooctanoic acid is involved in the preparation of lactams using enzyme catalyzed aminolysis.

Definition

ChEBI: 8-aminooctanoic acid is an omega-amino fatty acid that is octanoic acid which carries an amino group at position 8. It has a role as a human metabolite. It is a medium-chain fatty acid and an omega-amino fatty acid.

Reactivity Profile

Other lactams such as butyrolactam, d-valerolactam, and dimer and trimer lactams can be formed from enzymatic reactions of 4-aminobutanoic acid, 5-aminovaleric acid, and 8-aminooctanoic acid using N435 as the catalyst. For reactions using 8-aminooctanoic acid as the substrate, N435 did not catalyze the formation of caprylolactam. Instead, the corresponding dimer and trimer lactams were formed. The formation of macrocyclic bislactams from reactions between diesters and diamines using porcine pancreatic lipase as the catalyst was previously reported. However, in the enzymatic reaction of 8-aminooctanoic acid using N435, different macrocyclic dimer and trimer lactams were formed in a ratio of 3:2. The ratio was calculated from the mass spectrometric peak intensities of the product[2].

Synthesis

In a 1 l flask with paddle stirrer, internal thermometer and reflux condenser, 142.6 g (1 mol) of 2-azacyclononanone and 110 g (1 mol) of about 36 wt.-% sodium hydroxide solution are boiled under reflux for 4 hours. The solution is subsequently cooled to about 80 °C and mixed with Lewatit SP-112?. After one hour, the acidic ion exchanger is filtered. 500 g of 2-Propanol is added dropwise to the mixture at 80 °C, and the homogeneous solution is slowly cooled to -5 °C. The precipitated solid is filtered and washed with 50 g of 2-propanol. After drying at 85 °C and 20 mbar, 8-Aminooctanoic acid is obtained as a fine colorless powder. A colorless powder. Yield: 127 g (80%). Melting point: 191-193 °C (Lit.: 194 °C).

structure and hydrogen bonding

References

[1] A J Dobson, R E Gerkin. “8-Aminocaprylic acid.” Acta crystallographica. Section C, Crystal structure communications 54 ( Pt 7) (1998): 969–72.
[2] E. Stavila, K. Loos. “Synthesis of lactams using enzyme-catalyzed aminolysis.” Tetrahedron Letters 54 5 (2013): Pages 370-372.

8-Aminooctanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Aminooctanoic acid Suppliers

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View Lastest Price from 8-Aminooctanoic acid manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 8-Aminooctanoic acid 1002-57-9
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-12

Hebei Fengjia New Material Co., Ltd

Product: 8-Aminooctanoic acid 1002-57-9
Price: US $4.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2024-09-12

Hangzhou ICH Biofarm Co., Ltd

Product: 8-Aminooctanoic acid 1002-57-9
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-06-09

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