2-Amino-5-nitro-4-picoline

Product Name: 2-Amino-5-nitro-4-picoline
CAS No.: 21901-40-6
Chemical Name: 2-Amino-5-nitro-4-picoline
Synonyms: 2-AMINO-5-NITRO-4-PICOLINE;2-Amino-5-nitro-4-picoline,98%;4-Methyl-5-nitro-2-pyridinamine;4-methyl-5-nitropyridin-2-amine;2-AMiono-4Methyl-5Nitropyridine;2-Amino-4-Mythyl-5-NitroPyridine;2-Amino-5-nitro-4-methylpyridine;4-Methyl-5-nitropyridine-2-amine;2-Pyridinamine,4-methyl-5-nitro-;2-AMINO-4-METHYL-5-NITROPYRIDINE
CBNumber: CB0349709
Molecular Formula: C6H7N3O2
Formula Weight: 153.14
MOL File: 21901-40-6.mol

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2-Amino-5-nitro-4-picoline Property

Melting point:: 223-225 °C (lit.)
Boiling point:: 276.04°C (rough estimate)
Density: 1.3682 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Soluble in DMSO.
pka: 3.44±0.24(Predicted)
form: Powder
color: Orange to yellow-brown
BRN: 137695
InChI: InChI=1S/C6H7N3O2/c1-4-2-6(7)8-3-5(4)9(10)11/h2-3H,1H3,(H2,7,8)
InChIKey: GRBBNZYMXKTQAI-UHFFFAOYSA-N
SMILES: C1(N)=NC=C([N+]([O-])=O)C(C)=C1
CAS DataBase Reference: 21901-40-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-37/39-36/37/39-22-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 290092
Product name: 2-Amino-4-methyl-5-nitropyridine
Purity: 98%
Packaging: 1g
Price: $38.2
Updated: 2025/07/31

TCI Chemical

Product number: A1638
Product name: 2-Amino-4-methyl-5-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: A1638
Product name: 2-Amino-4-methyl-5-nitropyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $127
Updated: 2025/07/31

TRC

Product number: M325180
Product name: 4-Methyl-5-nitro-2-pyridinamine
Packaging: 2.5g
Price: $120
Updated: 2021/12/16

TRC

Product number: M325180
Product name: 4-Methyl-5-nitro-2-pyridinamine
Packaging: 10g
Price: $250
Updated: 2021/12/16

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2-Amino-5-nitro-4-picoline Chemical Properties,Usage,Production

Chemical Properties

orange to yellow-brown powder

Uses

2-Amino-4-methyl-5-nitropyridine was used in the preparation of matrix mixture required to study new technical developments for the direct tissue analysis of peptides.

General Description

The crystal structure of 2-amino-4-methyl-5-nitropyridine was elucidated.

Synthesis

695-34-1

21901-40-6

Example 9: Synthesis of 2-(1-aziridinyl)-4-carbamoyl-5-nitropyridine (Compound VI) Reagents and conditions: (i) HNO3/H2SO4; (ii) NaNO2; (iii) POCl3; (iv) Na2Cr2O7; (v) SOCl2/DMF, followed by NH4OH treatment; (vi) aziridine. Synthesis steps for compound 30: 1. cool concentrated sulfuric acid (240 mL) in an ice bath and slowly add raw compound 29 (2-amino-4-methylpyridine, 50 g, 0.462 mol), keeping the temperature at 0°C. 2. slowly add acid mixture prepared from concentrated sulfuric acid (98%, 55 mL) and concentrated nitric acid (72%, 55 mL) in a 1:1 volume ratio. 3. slowly heat to 50°C and react for 24 hours to ensure complete reaction. 4. Pour the reaction solution into 2 L of ice water, adjust the pH to 7 with a strong base, and filter to collect the precipitate. 5. Dry the filter cake to give 54 g of crude product. 6. The by-product 4-methyl-3-nitro-2-aminopyridine was removed by wet distillation and subsequently recrystallized in 95% ethanol to give 33 g of Compound 30 (2-amino-4-methyl-5-nitropyridine) with a melting point of 220-222 °C (Literature value: 220-222 °C). Yield: 46.6%.

References

[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 12-13
[2] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0044
[3] Patent: WO2005/97129, 2005, A2. Location in patent: Page/Page column 176
[4] Patent: WO2012/103806, 2012, A1. Location in patent: Page/Page column 43

2-Amino-5-nitro-4-picoline Preparation Products And Raw materials

Raw materials

Nitric acid Sulfuric acid 4-Methylpyridin-2-amine

Preparation Products

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2-Amino-5-nitro-4-picoline Suppliers

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View Lastest Price from 2-Amino-5-nitro-4-picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Amino-5-nitro-4-picoline 21901-40-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Henan Fengda Chemical Co., Ltd

Product: 2-Amino-5-nitro-4-picoline 21901-40-6
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Dideu Industries Group Limited

Product: 2-Amino-5-nitro-4-picoline 21901-40-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-07

21901-40-6, 2-Amino-5-nitro-4-picolineRelated Search:

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2-Amino-5-nitro-4-picoline ISO 9001：2015 REACH

21901-40-6

Heterocyclic Building Blocks

Pyridines

Building Blocks

C6

Pyridine

Pyridines, Pyrimidines, Purines and Pteredines

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks

Heterocycle-Pyridine series

amine |nitro-compound

compounds of pyridine

Amino-pyridine series

Amines

Pyridines

Pyridines derivates

Heterocyclic Building Blocks

bc0001

C6