ChemicalBook > CAS DataBase List > 2-Amino-5-nitro-4-picoline

2-Amino-5-nitro-4-picoline

Product Name
2-Amino-5-nitro-4-picoline
CAS No.
21901-40-6
Chemical Name
2-Amino-5-nitro-4-picoline
Synonyms
2-AMINO-5-NITRO-4-PICOLINE;2-Amino-5-nitro-4-picoline,98%;4-Methyl-5-nitro-2-pyridinamine;4-methyl-5-nitropyridin-2-amine;2-AMiono-4Methyl-5Nitropyridine;2-Amino-4-Mythyl-5-NitroPyridine;2-Amino-5-nitro-4-methylpyridine;4-Methyl-5-nitropyridine-2-amine;2-Pyridinamine,4-methyl-5-nitro-;2-AMINO-4-METHYL-5-NITROPYRIDINE
CBNumber
CB0349709
Molecular Formula
C6H7N3O2
Formula Weight
153.14
MOL File
21901-40-6.mol
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2-Amino-5-nitro-4-picoline Property

Melting point:
223-225 °C (lit.)
Boiling point:
276.04°C (rough estimate)
Density 
1.3682 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in DMSO.
pka
3.44±0.24(Predicted)
form 
Powder
color 
Orange to yellow-brown
BRN 
137695
InChI
InChI=1S/C6H7N3O2/c1-4-2-6(7)8-3-5(4)9(10)11/h2-3H,1H3,(H2,7,8)
InChIKey
GRBBNZYMXKTQAI-UHFFFAOYSA-N
SMILES
C1(N)=NC=C([N+]([O-])=O)C(C)=C1
CAS DataBase Reference
21901-40-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-37/39-36/37/39-22-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
290092
Product name
2-Amino-4-methyl-5-nitropyridine
Purity
98%
Packaging
1g
Price
$38.2
Updated
2025/07/31
TCI Chemical
Product number
A1638
Product name
2-Amino-4-methyl-5-nitropyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
A1638
Product name
2-Amino-4-methyl-5-nitropyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$127
Updated
2025/07/31
TRC
Product number
M325180
Product name
4-Methyl-5-nitro-2-pyridinamine
Packaging
2.5g
Price
$120
Updated
2021/12/16
TRC
Product number
M325180
Product name
4-Methyl-5-nitro-2-pyridinamine
Packaging
10g
Price
$250
Updated
2021/12/16
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2-Amino-5-nitro-4-picoline Chemical Properties,Usage,Production

Chemical Properties

orange to yellow-brown powder

Uses

2-Amino-4-methyl-5-nitropyridine was used in the preparation of matrix mixture required to study new technical developments for the direct tissue analysis of peptides.

General Description

The crystal structure of 2-amino-4-methyl-5-nitropyridine was elucidated.

Synthesis

695-34-1

21901-40-6

Example 9: Synthesis of 2-(1-aziridinyl)-4-carbamoyl-5-nitropyridine (Compound VI) Reagents and conditions: (i) HNO3/H2SO4; (ii) NaNO2; (iii) POCl3; (iv) Na2Cr2O7; (v) SOCl2/DMF, followed by NH4OH treatment; (vi) aziridine. Synthesis steps for compound 30: 1. cool concentrated sulfuric acid (240 mL) in an ice bath and slowly add raw compound 29 (2-amino-4-methylpyridine, 50 g, 0.462 mol), keeping the temperature at 0°C. 2. slowly add acid mixture prepared from concentrated sulfuric acid (98%, 55 mL) and concentrated nitric acid (72%, 55 mL) in a 1:1 volume ratio. 3. slowly heat to 50°C and react for 24 hours to ensure complete reaction. 4. Pour the reaction solution into 2 L of ice water, adjust the pH to 7 with a strong base, and filter to collect the precipitate. 5. Dry the filter cake to give 54 g of crude product. 6. The by-product 4-methyl-3-nitro-2-aminopyridine was removed by wet distillation and subsequently recrystallized in 95% ethanol to give 33 g of Compound 30 (2-amino-4-methyl-5-nitropyridine) with a melting point of 220-222 °C (Literature value: 220-222 °C). Yield: 46.6%.

References

[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 12-13
[2] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0044
[3] Patent: WO2005/97129, 2005, A2. Location in patent: Page/Page column 176
[4] Patent: WO2012/103806, 2012, A1. Location in patent: Page/Page column 43

2-Amino-5-nitro-4-picoline Preparation Products And Raw materials

Raw materials

Nitric acid Sulfuric acid 4-Methylpyridin-2-amine

Preparation Products

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2-Amino-5-nitro-4-picoline Suppliers

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View Lastest Price from 2-Amino-5-nitro-4-picoline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Amino-5-nitro-4-picoline 21901-40-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-29
Henan Fengda Chemical Co., Ltd
Product
2-Amino-5-nitro-4-picoline 21901-40-6
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Dideu Industries Group Limited
Product
2-Amino-5-nitro-4-picoline 21901-40-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-07

21901-40-6, 2-Amino-5-nitro-4-picolineRelated Search:

4-Methylpyridine 2-Bromo-5-nitropyridine 3-Amino-4-methylpyridine METSULFURON METHYL 2-Aminopyridine 4-Dimethylaminopyridine Methyl salicylate 2-Methyl-5-nitropyridine 4-Methylpyridin-2-amine Kresoxim-methyl Methylparaben 2-Amino-5-nitropyridine 3-Aminopyridine Methyl acetate Bensulfuron methyl Thiophanate-methyl Tris(hydroxymethyl)aminomethane Methyl

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  • Pyridine
  • Pyridines, Pyrimidines, Purines and Pteredines
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  • Heterocyclic Building Blocks
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