ChemicalBook > CAS DataBase List > Ethyl 2-aminopyridine-3-carboxylate

Ethyl 2-aminopyridine-3-carboxylate

Product Name
Ethyl 2-aminopyridine-3-carboxylate
CAS No.
13362-26-0
Chemical Name
Ethyl 2-aminopyridine-3-carboxylate
Synonyms
AKOS 90517;BUTTPARK 23\07-65;RARECHEM AL BI 1234;Nicorandil Impurity 47;ETHYL 2-AMINONICOTINATE;Ethyl2-Aminonicotinate>Nicotinic Acid Impurity 12;Nicotinic acid Impurity 10;Ethyl 2-aMinonicotinic acid;Ethyl 2-aminonicotinate ,97%
CBNumber
CB0352475
Molecular Formula
C8H10N2O2
Formula Weight
166.18
MOL File
13362-26-0.mol
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Ethyl 2-aminopyridine-3-carboxylate Property

Melting point:
96-98°C
Boiling point:
133°C/12mmHg(lit.)
Density 
1.192±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO, Methanol
pka
4.84±0.36(Predicted)
form 
Solid
color 
Yellow
InChI
InChI=1S/C8H10N2O2/c1-2-12-8(11)6-4-3-5-10-7(6)9/h3-5H,2H2,1H3,(H2,9,10)
InChIKey
KIAGEDYOPMHRRB-UHFFFAOYSA-N
SMILES
C1(N)=NC=CC=C1C(OCC)=O
CAS DataBase Reference
13362-26-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
E1146
Product name
Ethyl 2-Aminonicotinate
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
E1146
Product name
Ethyl 2-Aminonicotinate
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$127
Updated
2025/07/31
TRC
Product number
E705500
Product name
Ethyl2-Aminopyridine-3-carboxylate
Packaging
2g
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR15285
Product name
Ethyl 2-Aminonicotinate
Purity
98%
Packaging
25g
Price
$73
Updated
2021/12/16
Matrix Scientific
Product number
046036
Product name
Ethyl 2-aminonicotinate
Purity
>95%
Packaging
25g
Price
$58
Updated
2021/12/16
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Ethyl 2-aminopyridine-3-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

A pyrimidine derivative with diuretic activity.

Synthesis

5345-47-1

64-17-5

13362-26-0

2-Aminonicotinic acid (1) (5 g, 36 mmol) and ethanol (100 mL) were used as feedstock to which concentrated sulfuric acid (10 mL) was added. The reaction mixture was heated to reflux for 16 hours and subsequently cooled to room temperature. The completion of the reaction was confirmed by LC-MS analysis. The volatiles were removed under vacuum, water was added, and the crude product was alkalized with 1N NaOH solution to pH 8.0. The product was extracted twice with ethyl acetate, and the organic phases were combined, dried over magnesium sulfate, and then concentrated to afford ethyl (2) 2-aminonicotinate (6.0 g, 100% yield) as a white crystalline solid. hplc-ms analysis results: retention time t R = 0.41 min (UV 254 nm); mass calculated value C8H10N2O2 166.1, measured value LCMS m/z 167.1 (M + H).

References

[1] Patent: WO2008/82490, 2008, A2. Location in patent: Page/Page column 70
[2] Patent: TWI525093, 2016, B. Location in patent: Page/Page column 101;
[3] Patent: WO2007/67416, 2007, A2. Location in patent: Page/Page column 64; 134
[4] Patent: WO2007/86080, 2007, A2. Location in patent: Page/Page column 37
[5] Heterocycles, 1993, vol. 36, # 11, p. 2513 - 2522

Ethyl 2-aminopyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

Acetic anhydride 2-Amino-3-picoline Benzene Potassium permanganate Thionyl chloride

Preparation Products

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View Lastest Price from Ethyl 2-aminopyridine-3-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Ethyl 2-aminopyridine-3-carboxylate 13362-26-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-09
Dideu Industries Group Limited
Product
Ethyl 2-aminopyridine-3-carboxylate 13362-26-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl 2-aminopyridine-3-carboxylate 13362-26-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

13362-26-0, Ethyl 2-aminopyridine-3-carboxylateRelated Search:

Acetaminophen 2-Ethoxyethanol ISOXADIFEN-ETHYL Trinexapac-ethyl Ethyl 5-bromonicotinate Urethane Ethyl acetate RESMETHRIN Ethyl isonicotinate Ethylparaben Ethyl formate Ethyl 6-chloronicotinate Ethanol EC 2.6.1.2 Ethyl 3-aminopropanoate hydrochloride Tris(trimethylsilyl)phosphate 2-AMINODIETHYLMALONATE Dimethyl succinate

  • Ethyl 2-aMinonicotinic acid
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  • Nicotinic Acid Impurity 12
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  • Ethyl 2-aminopyridine-3-carboxylate ISO 9001：2015 REACH
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  • 13362-26-0
  • Amines
  • Heterocycles
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  • Pyridine