ARG-GLY-ASP

Product Name: ARG-GLY-ASP
CAS No.: 99896-85-2
Chemical Name: ARG-GLY-ASP
Synonyms: RGD;F-336;H2N-RGD-OH;ARG-GLY-ASP;L-ARG-GLY-ASP;H-ARG-GLY-ASP-OH;RGD (Arg-Gly-Asp);Arg-Gly-Asp (TLC);RGD PEPTIDE (CORE);Arg-Gly-Asp acetate
CBNumber: CB0364876
Molecular Formula: C12H22N6O6
Formula Weight: 346.34
MOL File: 99896-85-2.mol

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ARG-GLY-ASP Property

Melting point:: 153-155℃ (ethyl ether )
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in 0.1N acetic acid at 20mg/ml
pka: 2.85±0.10(Predicted)
form: Powder
color: White to off-white
Water Solubility: Soluble to 12 mg/mL (34.64 mM) in Water
InChIKey: IYMAXBFPHPZYIK-BQBZGAKWSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A8052
Product name: Arg-Gly-Asp
Purity: ≥97% (TLC)
Packaging: 1mg
Price: $34.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: A8052
Product name: Arg-Gly-Asp
Purity: ≥97% (TLC)
Packaging: 5mg
Price: $101
Updated: 2024/03/01

Alfa Aesar

Product number: J65468
Product name: Arg-Gly-Asp
Packaging: 5mg
Price: $164
Updated: 2023/06/20

Sigma-Aldrich

Product number: A8052
Product name: Arg-Gly-Asp
Purity: ≥97% (TLC)
Packaging: 10mg
Price: $182
Updated: 2024/03/01

Usbiological

Product number: 260168
Product name: Arg-Gly-Asp
Packaging: 50mg
Price: $305
Updated: 2021/12/16

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ARG-GLY-ASP Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Arg-Gly-Asp has been used:

to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
in adhesion assay
in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
in textile fabrication and RGD textile functionalization
to engineer a population of human dermal fibroblasts with impaired migration
to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
in the cell culture of human mammary epithelial cells

Definition

ChEBI: Arg-Gly-Asp is an oligopeptide.

General Description

Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.

Biological Activity

synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.

Biochem/physiol Actions

Primary sequence involved with the binding of proteins to cell surfaces

in vitro

rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].

in vivo

anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].

target

integrin-ligand interaction

storage

Store at -20°C

References

[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.

ARG-GLY-ASP Preparation Products And Raw materials

Raw materials

Preparation Products

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ARG-GLY-ASP Suppliers

China 157 China Hong Kong 1 France 1 Germany 3 India 1 Japan 2 Switzerland 1 United Kingdom 4 United States 22 Global 192

MedChemexpress LLC

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SynPep Corporation

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New England Peptide, Inc.

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View Lastest Price from ARG-GLY-ASP manufacturers

Qingdao Xinli Technology Development Co., Ltd.

Product: Arg-Gly-Asp 99896-85-2
Price: US $40.00-35.00/Box
Min. Order: 1Box
Purity: 99%
Supply Ability: 1000 boxs
Release date: 2024-07-04

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Arginyl-glycyl-aspartic acid 99896-85-2
Price: US $90.00-900.00/KG
Min. Order: 1KG
Purity: 0.98
Supply Ability: 20 tons
Release date: 2023-10-25

Shaanxi Dideu Medichem Co. Ltd

Product: ARG-GLY-ASP 99896-85-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

99896-85-2, ARG-GLY-ASPRelated Search:

L-Glutamic acid, N-(N-L-arginylglycyl)- H-ARG-GLY-ASP-VAL-OH L-ARG-GLY-ASP-SER,H-ARG-GLY-ASP-SER-OH THYMOPOIETIN II (32-34) H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH H-GLY-ARG-GLY-ASP-SER-PRO-CYS-OH H-GLY-ARG-GLY-ASP-SER-OH GLY-PEN-GLY-ARG-GLY-ASP-SER-PRO-CYS-ALA H-ALA-CYS-ASP-CYS-ARG-GLY-ASP-CYS-PHE-CYS-GLY-OH (DISULFIDE BRIDGE: 2-10 AND 4-8) H-ARG-GLY-ASP-CYS-OH H-ARG-ARG-GLY-ASP-MET-GLU-OH H-GLY-ARG-GLY-ASP-THR-PRO-OH,GLY-ARG-GLY-ASP-THR-PRO H-GLY-ARG-GLY-ASP-ASN-PRO-OH SAR-ARG-GLY-ASP-SER-PRO,SAR-ARG-GLY-ASP-SER-PRO-OH TRP-ASN-ARG-GLN-LEU-TYR-PRO-GLU-TRP-THR-GLU-ALA-GLN-ARG-LEU-ASP ARG-GLY-ASP HIS-GLN-VAL-SER-LEU-SER-LYS-GLN-PRO-THR-SER-GLN-PRO-ARG-GLY-ASP H-GLY-ARG-GLY-ASP-OH

H2N-RGD-OH

H-ARG-GLY-ASP-OH

L-ARG-GLY-ASP

ARGINYL-GLYCYL-ASPARTIC ACID

ARG-GLY-ASP

ARG-GLY-ASP PEPTIDE

Arg-Gly-Asp acetate

Arginyl-glycyl-asparagilin

F-336

L-Aspartic acid, N-(N-L-arginylglycyl)-

N-(N-L-Arginylglycyl)-L-aspartic acid

Rgd tripeptide sequence

RGD (Arg-Gly-Asp) Peptides

Arginyl - glycyl - aspartate

L-Arginylglycyl-L-aspartic acid

RGD

RGD PEPTIDE (CORE)

L-Aspartic acid, L-arginylglycyl-

H-Arg-Gly-Asp-OH≥ 98% (HPLC)

Arg-Gly-Asp, ≥97% (HPLC)

Arg-Gly-Asp >=97% (TLC)

ARG-GLY-ASP USP/EP/BP

(S)-2-(2-((S)-2-Amino-5-guanidinopentanamido)acetamido)succinic acid

RGD (Arg-Gly-Asp)

Arg-Gly-Asp (TLC)

Integrin,RGD,inhibit,Inhibitor

Arginine-glycine-aspartic acid

99896-85-2

C12H22N6O6

Cell Biology

Cell Signaling and Neuroscience

Extracellular Matrix

Extracellular Matrix Peptides and Proteins

Cytoskeleton and Extracellular Matrix

BioChemical

Peptide

Cell Signaling Enzymes

ECM ProteinsCytoskeleton and Extracellular Matrix

Extracellular Matrix

Extracellular Matrix Peptides (ECM)

Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology

Fibronectin Fragments and Analogs

Matrix Metalloproteinases Products

Various Peptides