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Creatine monohydrate

Product Name
Creatine monohydrate
CAS No.
6020-87-7
Chemical Name
Creatine monohydrate
Synonyms
Creatine Mono;N-GUANYL-N-METHYLGLYCINE;Creatine Ethyl Ester;CREATINE MONOHYDRATE 200 MESH;Creatine monohydrate powder;CREATINE HYDRATE;N-AMIDINOSARCOSINE;N-AMIDINOSARCOSINE MONOHYDRATE;Creatine Monohydrate, 99% 100GR;2-(1-Methylguanidino)acetic acid hydrate
CBNumber
CB0387257
Molecular Formula
C4H11N3O3
Formula Weight
149.15
MOL File
6020-87-7.mol
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Creatine monohydrate Property

Melting point:
292 °C (dec.)(lit.)
RTECS 
MB7706000
storage temp. 
2-8°C
solubility 
slightly soluble in water, insoluble in ethanol and ether.
form 
Crystalline Powder
color 
White to yellow
PH
6.9 (10g/l, H2O, 20℃)
Water Solubility 
13 g/L (20 ºC)
Merck 
14,2568
BRN 
907175
Stability:
Hygroscopic
InChI
InChI=1S/C4H9N3O2.H2O/c1-7(4(5)6)2-3(8)9;/h2H2,1H3,(H3,5,6)(H,8,9);1H2
InChIKey
MEJYXFHCRXAUIL-UHFFFAOYSA-N
SMILES
N(C)(C(N)=N)CC(=O)O.O
LogP
-1.877 (est)
CAS DataBase Reference
6020-87-7(CAS DataBase Reference)
NIST Chemistry Reference
Creatine hydrate(6020-87-7)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36
WGK Germany 
1
TSCA 
Yes
HS Code 
29252000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C3630
Product name
Creatine monohydrate
Purity
≥98%
Packaging
1kg
Price
$335
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41470
Product name
Creatine monohydrate
Purity
for synthesis
Packaging
50G
Price
$71
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41470
Product name
Creatine monohydrate
Purity
for synthesis
Packaging
250G
Price
$205
Updated
2024/03/01
Sigma-Aldrich
Product number
1150320
Product name
Creatine monohydrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$406
Updated
2024/03/01
TCI Chemical
Product number
C0396
Product name
Creatine Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$19
Updated
2024/03/01
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Creatine monohydrate Chemical Properties,Usage,Production

Description

Creatine Monohydrate is the monohydrate form of creatine similar or identical to endogenous creatine produced in the liver, kidneys, and pancreas. Pure creatine is a white, tasteless,odorless powder, that is a naturally occurring metabolite found in muscle tissue.
Creatine monohydrate is an amino acid produced in the human body that plays a role in replenishing the energy supply to muscle cells.Creatine is usually produced to a purity of 99.5 percent or higher.Until recently, the primary use for creatine was as a laboratory reagent, demand for which was relatively limited.In the early 1990's, however, weight trainersand other athletes began using creatine in the belief that it stimulates muscle growth and reduces muscle fatigue.

Chemical Properties

Creatine monohydrate is a colorless, crystalline substance used in muscle tissue for the production of phosphocreatine, an important factor in the formation of adenosine triphosphate (ATP), the source of energy for muscle contraction and many other functions in the body.

Uses

Creatine is a natural compound made from the amino acids l-arginine, glycine, and methionine.Creatine monohydrate is a creatine with one molecule of water connected to it. Our bodies can produce creatine, however they also can take in and store creatine found in diverse meals like meat, eggs, and fish.

Creatine monohydrate supplementation is promoted as an ergogenic aid, which refers to a product purported to enhance energy production,utilization, control, and efficiency (Mujika and Padilla,1997).Creatine is purported to increase power, strength, and muscle mass and to decrease performance time (Demant et al.,1999).
Involved with rapid ATP production primarily in skeletal muscle tissue via the action of creatine kinase(s).

Uses

Creatine monohydrate is involved in rapid ATP production primarily in skeletal muscle tissue via the action of creatine kinase(s). It may be used as a supplement to study its uptake mechanism and metabolism of action. It is used in the treatment of neuromuscular diseases.

Preparation

Creatine monohydrate can be synthesized in the laboratory (and commercially), starting from cyanamide and sarcosine (N-methylglycine).

Creatine is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle by playing a key role in muscle energy metabolism. It is produced in the liver, pancreas, and kidneys and can also be derived from food and dietary supplements. Creatine provides the energy needed for muscle contraction and substantially improves performance in high-intensity exercise because it improves anaerobic capacity and protein synthesis. Therapeutically, it has been used to treat some types of muscular dystrophy, ocular atrophy, and some types of sclerosis. Creatine (a dietary supplement) is demanded by many athletes and is neither regulated by the Food and Drug Administration (FDA) nor prohibited by the International Olympic Committee (IOC).

benefits

Creatine has many benefits for health and performance. The most common is creatine monohydrate, a dietary supplement that improve strength, increase lean muscle mass, and help the muscles recover more quickly during exercise. It can also inhibit the generation of muscle fatigue factors, reduce fatigue and tension, restore physical fitness, accelerate protein synthesis in the human body, make muscles stronger, enhance muscle elasticity, reduce cholesterol, blood lipids, and blood sugar levels, improve middle-aged and elderly Muscular dystrophy, and delay aging.

Biochem/physiol Actions

Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP. Approximately 95% of creatine is found in skeletal muscle, primarily as phosphocreatine. Creatine can be acquired through dietary consumption or formed from L-arginine, glycine, and L-methionine in a multi-step reaction that occurs in the kidneys and liver. Creatine is then transported to muscle tissue. Creatine supplementation is used for the enhancement of sports performance, primarily by increasing muscle mass. Creatine is also being investigated as a treatment of neuromuscular diseases, where it may aid in neuroprotection and by improving the cellular bioenergetic state.

Mechanism of action

Early research proposed that the osmotic effect of creatine supplementation serves as a cellular stressor (osmosensing) that acts as an anabolic stimulus for protein synthesis signal pathways. Other reports indicated that creatine directly affects muscle protein synthesis via modulations of components in the mammalian target of rapamycin (mTOR) pathway. Creatine may also directly affect the myogenic process (formation of muscle tissue), by altering secretions of myokines, such as myostatin and insulin-like growth factor-1, and expressions of myogenic regulatory factors, resulting in enhanced satellite cells mitotic activities and differentiation into myofiber. Overall, there is still no clear understanding of the mechanisms of action regarding how creatine affects muscle mass/growth, but current evidence suggests it may exert its effects through multiple approaches, with converging impacts on protein synthesis and myogenesis.

Side effects

Weight gain
Muscle cramps
Muscle strains and pulls
Stomach upset
Diarrhea
Dizziness
High blood pressure Liver dysfunction
Kidney damage

Purification Methods

Likely impurities are creatinine and other guanidino compounds. It crystallises from the minimum volume of boiling H2O as the monohydrate. The hydrate is also obtained by dissolving in H2O and adding Me2CO. Drying under vacuum over P2O5 or drying at 100o gives the anhydrous base. The anhydrous base can be obtained also by dissolving the hydrate in H2O, seeding with the anhydrous base and cooling in ice. A m of 258 -268o(dec) was reported. The picrate crystallises from 17 parts of H2O with m of 218-220o(dec). [King J Chem Soc 2377 1930, Hoffmann et al. J Am Chem Soc 58 1730 1936, Mendel & Hodgkin Acta Cryst 7 443 1954, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2750 1961, Beilstein 4 III 1170, 4 IV 2425.]

Creatine monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Creatine monohydrate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Creatine monohydrate 6020-87-7
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-03-25
Hebei Yime New Material Technology Co., Ltd.
Product
CREATINE MONOHYDRATE 6020-87-7
Price
US $7.00/kg
Min. Order
1000kg
Purity
99%
Supply Ability
5000kg/day
Release date
2023-11-07
Hebei Yime New Material Technology Co., Ltd.
Product
creatine monohydrate 200 mesh 6020-87-7
Price
US $7.00/kg
Min. Order
1000kg
Purity
99%
Supply Ability
5000kg/day
Release date
2024-01-12

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