2-Hydrazinopyridine
- Product Name
- 2-Hydrazinopyridine
- CAS No.
- 4930-98-7
- Chemical Name
- 2-Hydrazinopyridine
- Synonyms
- 2-hydrazinylpyridine;Hydrazinopyridine;2-PYRIDYLHYDRAZINE;pyridinylhydrazine;2-HYDRAZINOPYRIDINE;pyrid-2-ylhydrazine;2-Pyridinylhydrazine;Pacritinib Impurity 7;PYRIDIN-2-YL-HYDRAZINE;Pyridine, 2-hydrazino-
- CBNumber
- CB0389206
- Molecular Formula
- C5H7N3
- Formula Weight
- 109.13
- MOL File
- 4930-98-7.mol
2-Hydrazinopyridine Property
- Melting point:
- 41-44 °C (lit.)
- Boiling point:
- 90-92 °C/1 mmHg (lit.)
- Density
- 1.1118 (rough estimate)
- refractive index
- 1.5340 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- soluble in Methanol
- pka
- 9.72±0.70(Predicted)
- form
- crystalline
- color
- deep red
- BRN
- 109984
- InChIKey
- NWELCUKYUCBVKK-UHFFFAOYSA-N
- CAS DataBase Reference
- 4930-98-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Hydrazinopyridine(4930-98-7)
- EPA Substance Registry System
- 2-Hydrazinopyridine (4930-98-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H0888
- Product name
- 2-Hydrazinopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 10g
- Price
- $162
- Updated
- 2025/07/31
- Product number
- H0888
- Product name
- 2-Hydrazinopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $323
- Updated
- 2025/07/31
- Product number
- H17082
- Product name
- 2-Hydrazinopyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $30.34
- Updated
- 2025/07/31
- Product number
- H17082
- Product name
- 2-Hydrazinopyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $117.16
- Updated
- 2025/07/31
- Product number
- H17082
- Product name
- 2-Hydrazinopyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $272
- Updated
- 2025/07/31
2-Hydrazinopyridine Chemical Properties,Usage,Production
Chemical Properties
White to light beige low melting solid
Synthesis Reference(s)
Journal of Medicinal Chemistry, 28, p. 1394, 1985 DOI: 10.1021/jm00148a004
Synthesis
109-09-1
4930-98-7
General procedure for the synthesis of 2-hydrazinopyridine from 2-chloropyridine: To a solution of hydrazine hydrate (200 mL, 10 vol) of 2-chloropyridine (20 g, 0.176 mol, 1 eq.), the reaction was stirred for 48 hours at 100 °C. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding reagent ratio of 8:2 ethyl acetate and methanol), and after confirming that the feedstock was completely consumed, the reaction mixture was diluted with water (200 mL) and subsequently extracted with ethyl acetate (5 x 500 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent to afford the target product 2-hydrazinopyridine (15.0 g, 78% yield) as a red oil. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.14 (1H, d, J = 3Hz, Ar-H), 7.51-7.45 (1H, m, Ar-H), 6.71-6.66 (2H, m, Ar-H), 5.78 (1H, brs, -NH), 3.81 (2H, brs, -NH2).LCMS ANALYSIS: The calculated value of C5H7N3[M+H]+ was 109.13 and the measured value was 110.1.
Purification Methods
Purify it by distillation under a vacuum and by recrystallisation from Et2O/hexane. [Kauffmann et al. Justus Liebigs Ann Chem 656 103 1962, Potts & Burton J Org Chem 31 251 1966.] The mono-hydrochloride has m 183o(dec) from aqueous HCl, and the di-hydrochloride has m 214-215o. [Beilstein 22 II 487, 22 III/IV 7025, 22/14 V 486.]
References
[1] Synthetic Communications, 2011, vol. 41, # 6, p. 925 - 938
[2] Asian Journal of Chemistry, 2017, vol. 29, # 9, p. 1920 - 1924
[3] European Journal of Organic Chemistry, 2015, vol. 2015, # 23, p. 5064 - 5069
[4] Patent: EP1380296, 2004, A1
[5] Tetrahedron Letters, 2014, vol. 55, # 52, p. 7198 - 7202
2-Hydrazinopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Hydrazinopyridine Suppliers
- Tel
- --
- Fax
- --
- m.crocetta@angelini.it
- Country
- Italy
- ProdList
- 61
- Advantage
- 47
View Lastest Price from 2-Hydrazinopyridine manufacturers
- Product
- 2-Hydrazinylpyridine 4930-98-7
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 2-Hydrazinopyridine 4930-98-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-22
- Product
- 2-Hydrazinopyridine 4930-98-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25