Chlorzoxazone

Skeletal muscle relaxants Pharmacokinetics Indications Chlorzoxazone synthesis Medicine interactions Side effects Uses Category Toxicity grading Acute toxicity Flammability and hazard properties Storage characteristics Extinguishing agent

Product Name: Chlorzoxazone
CAS No.: 95-25-0
Chemical Name: Chlorzoxazone
Synonyms: Chloroxazone;Chlorzoxazon;5-CHLOROBENZO[D]OXAZOL-2(3H)-ONE;Mioran;Paraflex;CLORZOXAZONE;CHLOROZOXAZONE;Parafon Forte DSC;Chlorzoxazone-13C,15N,D2;5-chloro-3H-1,3-benzoxazol-2-one
CBNumber: CB0392987
Molecular Formula: C7H4ClNO2
Formula Weight: 169.57
MOL File: 95-25-0.mol

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Chlorzoxazone Property

Melting point:: 191-192 °C (lit.)
Density: 1.3771 (rough estimate)
refractive index: 1.5557 (estimate)
storage temp.: room temp
solubility: DMSO: soluble50mg/mL, clear
form: Powder
pka: pKa 8.3 (Uncertain)
color: white to off-white
Water Solubility: 0.1 g/100 mL
Merck: 14,2194
InChI: InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
InChIKey: TZFWDZFKRBELIQ-UHFFFAOYSA-N
SMILES: O1C2=CC=C(Cl)C=C2NC1=O
LogP: 1.816 (est)
CAS DataBase Reference: 95-25-0(CAS DataBase Reference)
NIST Chemistry Reference: Chlorzoxazone(95-25-0)
EPA Substance Registry System: Chlorzoxazone (95-25-0)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-24/25-37/39
WGK Germany: 3
RTECS: DM5250000
Hazard Note: Toxic/Irritant
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29349990
Toxicity: LD50 in mice (mg/kg): 3650 orally, 380 i.p. (suspensions); 440 orally, 183 i.p. (solns of Na salt) (Hofrichter)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C4397
Product name: Chlorzoxazone
Packaging: 25g
Price: $100
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1130505
Product name: Chlorzoxazone
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 350mg
Price: $406
Updated: 2025/07/31

TCI Chemical

Product number: C2237
Product name: Chlorzoxazone
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: C2237
Product name: Chlorzoxazone
Purity: >98.0%(GC)(T)
Packaging: 250g
Price: $180
Updated: 2021/12/16

Cayman Chemical

Product number: 18869
Product name: Chlorzoxazone
Purity: ≥98%
Packaging: 25g
Price: $37
Updated: 2024/03/01

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Chlorzoxazone Chemical Properties,Usage,Production

Skeletal muscle relaxants

Chlorzoxazone is an orally active central skeletal muscle relaxant with its chemical structure being completely different with all the other muscle relaxants. It, mainly through acting on the central cerebral cortex and the spinal cord, inhibits the multi-synaptic reflection related to muscle spasms and produces muscle relaxation, further relieves the spasm caused pain and increase the flexibility of the muscles involved. Acetaminophen belongs to non-steroidal anti-inflammatory drugs and may mainly exert the analgesic and antipyretic effects through the inhibition of prostaglandin synthesis. Muscle relaxation studies through mouse traction test have demonstrated that the compound Chlorzoxazone showed a dose-dependent muscle relaxant effect with excellent protective effect on the strychnine-induced seizures in mice. The existence of paracetamol in the compound chlorzoxazone tablets can further enhance the effect of chlorzoxazone. Hot plate analgesic tests have showed the compound chlorzoxazone has a significant analgesic effect in a dose-dependent manner. It also has antagonism effect on the painful writhing of mice caused by antimony potassium tartrate in a good dose-response relationship. Test results have showed that acetaminophen and chlorzoxazone analgesic synergy.
This information is edited by Xiongfeng Dai from Chemicalbook.

Pharmacokinetics

This product can be completely absorbed by the digestive tract with the plasma concentration reaching peak at 1.5-2 hours. It is distributed in muscle, kidney, liver, brain and fat. After 6 hours, the drug concentration decreases significantly. Almost all of the goods can subject to in vivo catabolism with the elimination half-life being about 1 hour.
This information is edited by Xiongfeng Dai from Chemicalbook.

Indications

Chlorzoxazone is suitable for the treatment of various kinds of acute and chronic soft tissue (muscles, ligaments and fascia) sprain, contusion, muscle pain after exercise, pain caused by muscle strain and the muscle spasms caused by the central nervous system lesions as well as chronic fasciitis.

Chlorzoxazone synthesis

Take 2, 5-dichloro-nitrobenzene as raw material; go through hydrolysis, reduction reaction to give 2-amino-4-chloro-phenol, followed by cyclization reaction in hydrochloric acid to obtain the finished product of Chlorzoxazone with the total yield being 84%.

Medicine interactions

When this product is used in combination with central inhibitory drugs such as phenothiazines and barbituric acid derivative and monoamine oxidase inhibition drugs, we should reduce the usage amount of this product.

Side effects

There may be occasionally mild drowsiness, dizziness, nausea, heart palpitations, weakness, abdominal pain and other reactions. This drug should be discontinued in case of allergic reactions. These adverse reactions are generally mild and may go away automatically or alleviated after stopping using this drug.

Uses

It can be used as pharmaceutical intermediates.
It can be used as central muscle relaxants, for being applied to a variety of soft tissue pain caused by chronic sprain, contusion and muscle strain as well as muscle spasms and pain caused by the central nervous system and so on.

Toxicity grading

Highly toxic.

Acute toxicity

Oral-rat LD50: 763 mg/kg; Oral-Mouse LD50: 440 mg/kg.

Flammability and hazard properties

Thermal decomposition can release nitrogen oxides and chlorides smoke.

Storage characteristics

Treasury: ventilated, low temperature and dry; store it separately from food raw materials.

Extinguishing agent

Water, carbon dioxide, foam, powder.

Description

Chlorzoxazone is a muscle relaxant. It acts by blocking nerve impulses or pain sensations that are sent to brain. Typically, it is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Chlorzoxazone, 5-chloro-2-benzoxazolione, is synthesized by a heterocyclization reaction of 2-amino-4-chlorophenol with phosgene. Skeletal muscle relaxants have conventionally been classified into one group; however, they are actually a heterogeneous group of medications commonly used to treat two different types of underlying conditions – spasticity from upper motor neuron syndromes and muscular pain or spasms from peripheral musculoskeletal conditions. Medications classified as skeletal muscle relaxants are baclofen, carisoprodol, chlorzoxazone, cyclobenzaprine, dantrolene, metaxalone, methocarbamol, orphenadrine, and tizanidine. These drugs may impair mental and/or physical abilities required for driving vehicles. As a class, skeletal muscle relaxants have central nervous system (CNS)-related side effects: drowsiness, dizziness, decreased alertness, blurred vision, and ataxia. Their use has been associated with a twofold increase in the risk for motor vehicle crashes. Muscle relaxants are included in the ‘Beers List’ of potentially inappropriate medications in older adults. Most muscle relaxants are poorly tolerated by elderly patients because they cause anticholinergic adverse effects, sedation, and weakness. Although extremely uncommon, this compound may yield to idiosyncratic and unpredictable type of liver toxicity. The concomitant use of alcohol or other CNS depressants may have an additive effect. Individuals on chlorzoxazone containing drugs should be monitored for abnormal liver enzymes (e.g., aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase, bilirubin, etc.).

Description

Chlorzoxazone is a centrally acting muscle relaxant and activator of small and intermediate conductance calcium-activated potassium channels (EC₅₀s = 87 and 98 μM for K_Ca2.2 and K_Ca3.1, respectively). In vivo, chlorzoxazone (10 mg/kg) decreases alcohol but not water intake in a dose-dependent manner and reduces the propensity for rapid initial alcohol intake in rats with intermittent, but not continuous, access to alcohol. Formulations containing chlorzoxazone have been used in the treatment of pain and stiffness caused by muscle spasm. This product is also available as an analytical reference standard .

Description

Chlorzoxazone (Item No. 25826) is an analytical reference standard categorized as a skeletal muscle relaxant. This product is intended for analytical forensic applications. This product is also available as a general research tool .

Chemical Properties

White to Off-White Solid

Originator

Paraflex ,McNeil, US ,1958

Uses

Chlorzoxazone is a benzoxazolone derivative that causes skeletal muscle relaxation and blocks spasticity in clinical studies. Chlorzoxazone enhances small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 μM for KCa2.2 and KCa3.1, respectively). The cytochrome P450 isoform CYP2E1 converts chlorzoxazone to 6-hydroxy chlorzoxazone . The urinary excretion of this 6-hydroxy metabolite is often used as a probe of CYP2E1 activity in studies of hepatotoxicity.

Uses

Muscle relaxant (skeletal)

Uses

For the relief of discomfort associated with acute painful musculoskeletal conditions.

Definition

ChEBI: A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful mus le spasm.

Manufacturing Process

A solution of 16.9 g (0.1 mol) of 2-amino-5-chlorobenzoxazole in 200 ml of 1 N HCl is refluxed until precipitation is complete. The resulting solid is collected
by filtration, dissolved in 200 ml of 1 N NaOH and the solution extracted with 50 ml of ether. Acidification of the alkaline solution gives a precipitate which is purified by crystallization from acetone to give 2-hydroxy-5-chlorobenzoxazole melting at 191° to 191.5°C.

brand name

Paraflex (Ortho-McNeil).

Therapeutic Function

Muscle relaxant

General Description

Chlorzoxazone is a centrally active muscle relaxant used to treat painful muscle spasms linked to musculoskeletal disorders, such as fibrositis, bursitis, myositis, spondylitis, etc.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Chlorzoxazone is a skeletal muscle relaxant.

Synthesis

Chlorzoxazone, 5-chloro-2-benzoxazolione (15.3.15), is synthesized by a hetercyclization reaction of 2-amino-4-chlorphenol with phosgene.

Environmental Fate

Chlorzoxazone ismetabolized by the CYP1A2 and CYP2E1 microsomal enzymes to a toxic metabolite 6-hydroxychlorzoxazone.

Toxicity evaluation

Chlorzoxazone is a white to off-white solid. It is soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO).

References

[1] P PEDARZANI M S. Molecular and cellular basis of small–and intermediate-conductance, calcium-activated potassium channel function in the brain.[J]. Cellular and Molecular Life Sciences, 2008, 65 20: 3196-3217. DOI: 10.1007/s00018-008-8216-x
[2] ZHENYU GAO. Cerebellar ataxia by enhanced Ca(V)2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1a(S218L) mutant mice.[J]. Journal of Neuroscience, 2012, 32 44: 15533-15546. DOI: 10.1523/jneurosci.2454-12.2012
[3] F. WOODWARD HOPF . Chlorzoxazone, an SK-Type Potassium Channel Activator Used in Humans, Reduces Excessive Alcohol Intake in Rats[J]. Biological Psychiatry, 2011, 69 7: Pages 618-624. DOI: 10.1016/j.biopsych.2010.11.011

Chlorzoxazone Preparation Products And Raw materials

Raw materials

4-CHLORO-2-NITROPHENOL 4-Chlorophenol

Preparation Products

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View Lastest Price from Chlorzoxazone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Chlorzoxazone 95-25-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1000kg/month
Release date: 2021-07-01

Sinoway Industrial co., ltd.

Product: Chlorzoxazone 95-25-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-03-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: Chlorzoxazone 95-25-0
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2024-08-23

95-25-0, ChlorzoxazoneRelated Search:

Cefazolin sodium salt Epichlorohydrin 1,2-Benzisothiazol-3(2H)-one Trazodone Nizofenone 4'-Chloroacetophenone 2,4-Dichloro-5-fluoroacetophenone 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Chloroacetic acid Difluorochloromethane Cibenzoline succinate 6-HYDROXY CHLORZOXAZONE-D2,CHLORZOXAZONE, 6-HYDROXY MAJOR METABOLIT E OF C bromchlorenone Oxazole 2-Benzoxazolinone 5-CHLOROBENZOXAZOLE (5-CHLORO-2-OXO-BENZOOXAZOL-3-YL)-ACETIC ACID CHLORZOXAZONE-4,6,7-D3

Biomioran

Chlorzoxazon

component of Parafon Forte

Escoflex

Mioran

Miotran

Myoflexin

Myoflexine

Neoflex

Paraflex

Parafon Forte DSC

parafonforte

Pathorysin

Solaxin

USAF ma-10

usafma-10

Chlorzoxane

CHLORZOXAZONE SKELETAL MUSCLE RELAX

Chlorzoxazone USP/BP

Chlorzoxazone, substrate for Cytochrome P450 2E

CHLORZOXAZONE (5-CHLORO-2-BENZOXAZOLONE)

CHLOROZOXAZONE

Chlorzoxazone, Chlorzoxazonum

TIMTEC-BB SBB003864

5-Chlorobenzoxazol-2(3H)-one

Chloroxazone

CHLORZOXAZONE

CLORZOXAZONE

5-Chlorobenzoxazol-2-one 99%

5-Chloro-2(3H)-benzoxazolone, 5-Chloro-2-hydroxybenzoxazole

Chloroxazone,98%

5-Chloro-2-benzoxazolinoone

5-CHLORO-2-BENZOXAZOLINONE

5-CHLORO-2-BENZOXAZOLONE

5-CHLORO-2-HYDROXYBENZOXAZOLE

5-chloro-2(3h)-benzoxazolone

5-CHLOROBENZO[D]OXAZOL-2(3H)-ONE

2(3H)-Benzoxazolone, 5-chloro-

2-Benzoxazolinone, 5-chloro-

2-Hydroxy-5-chlorobenzoxazole

5-Chlorbenzoxazolin-2-on

5-Chloro-1,3-benzoxazol-2(3H)-one

5-chloro-2(3h)-benzoxazolon

5-chloro-2-benzoxazolinon

5-Chloro-2-benzoxazolol

5-Chloro-3(H)-2-benzoxazolone

5-Chlorobenzoksazolinon-2

5-Chlorobenzoksazolon-2

5-Chlorobenzoxazol-2-one

5-Chlorobenzoxazolidone

5-Chlorobenzoxazolinone

5-Chlorobenzoxazolone

5-Chloro-2-benzoxazolone (Chlorzoxazone)

Chlorzoxazone,5-Chloro-2(3H)-benzoxazolone, 5-Chloro-2-hydroxybenzoxazole

Chlorzoxazone (350 mg)

Chlorzoxazone (500 mg)

Chlorzoxazone-13C,15N,D2

5-chloro-2,3-dihydro-1,3-benzoxazol-2-one