Taxifolin

Structural chemistry

Product Name: Taxifolin
CAS No.: 480-18-2
Chemical Name: Taxifolin
Synonyms: DIHYDROQUERCETIN;distylin;taxifoliol;Larch extract;(+)-TAXIFOLIN;(2R,3R)-(+)-Taxifolin;(2R,3R)-DIHYDROQUERCETIN;Taxifolin (Dihydroquercetin);CPD-474;Lavitol
CBNumber: CB0402424
Molecular Formula: C15H12O7
Formula Weight: 304.25
MOL File: 480-18-2.mol

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Taxifolin Property

Melting point:: 230-233°C (dec.)
Boiling point:: 365.09°C (rough estimate)
Density: 1.3326 (rough estimate)
refractive index: 1.4790 (estimate)
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 7.39±0.60(Predicted)
form: Solid
color: White to Yellow
BRN: 5299277
InChI: InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
InChIKey: CXQWRCVTCMQVQX-LSDHHAIUSA-N
SMILES: [C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
LogP: 0.950
CAS DataBase Reference: 480-18-2(CAS DataBase Reference)
EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- (480-18-2)

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Safety

Risk Statements: 22
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: LK6920000
HazardClass: IRRITANT
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 78666
Product name: Taxifolin
Purity: analytical standard
Packaging: 25mg
Price: $75.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 78666
Product name: Taxifolin
Purity: analytical standard
Packaging: 100mg
Price: $254
Updated: 2024/03/01

Sigma-Aldrich

Product number: 03890585
Product name: Taxifolin
Purity: primary reference standard
Packaging: 10mg
Price: $330
Updated: 2023/06/20

TCI Chemical

Product number: T3666
Product name: (+)-Taxifolin
Packaging: 200MG
Price: $114
Updated: 2024/03/01

TCI Chemical

Product number: T3666
Product name: (+)-Taxifolin
Packaging: 1G
Price: $344
Updated: 2024/03/01

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Taxifolin Chemical Properties,Usage,Production

Structural chemistry

Taxifolin is a subclass of flavanonols, an isoflavanone in flavonoids family. The basic structure of two phenyl groups (ring A and ring B) which are joined together by a heterocyclic ring referred to as ring C . The structure contains 3-hydroxyl group at the C ring which is connected to the B ring at carbon-2. Taxifolin is a pentahydroxyflavone containing five hydroxyl groups at the 3-, 3'-, 4'-, 5- and 7-positions. It has two stereocenters on the C-ring and 4 stereoisomers. It with the configuration of (2R, 3R) is one of them and it comprises 2 pairs of enantiomers.

Description

Taxifolin, a chemical substance extracted from pine plants such as larch and Douglas fir. It belongs to the bioflavonoid pseudo-vitamin P, and its scientific name is dihydroquercetin. Japanese scholar Fukui first isolated it from the leaves of conifers (Chamaecyparis obtusa), and its biological activity was subsequently discovered and confirmed.

Chemical Properties

Yellow Solid

Uses

An antioxidant flavenoid.

Uses

Reference Standard in the analysis of herbal medicinal products

Uses

(+)-Taxifolin is a flavanon compound which modulates chemopreventive genes.

Definition

ChEBI: A taxifolin that has (2R,3R)-configuration.

Application

Taxifolin is a flavonoid commonly found in onion, milk, French maritime pine bark and Douglas fir bark. It is also used in various commercial preparations like Legalon?, Pycnogenol?, and Venoruton?. This review focuses on taxifolin’s biological activities and related molecular mechanisms. It showed promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders. The anti-cancer activity was more prominent than other activities evaluated using different in vitro and in vivo models. Further research on the pharmacokinetics, in-depth molecular mechanisms, and safety profile using well-designed randomized clinical studies are suggested to develop a drug for human use.

General Description

Taxifolin is a plant flavonoid, which may find applications in the treatment of coronary heart disease, angina pectoris, cerebral thrombosis, cerebral infarction and sequelae.

Taxifolin Preparation Products And Raw materials

Raw materials

Preparation Products

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Taxifolin Suppliers

Canada 2 CHINA 372 Czech Republic 1 Europe 2 France 1 Germany 8 India 7 Japan 2 South Korea 1 Switzerland 3 United Kingdom 8 United States 39 USA 1 Global 447

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
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Advantage: 66

Beckmann-Kenko GmbH

Tel: +49 4241 9308 88
Fax: +49 4241 9308 89
Email: info@beckmann-kenko.com
Country: Germany
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Advantage: 62

CHEMOS GmbH & Co. KG

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Country: Germany
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ABCR GmbH & CO. KG

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Country: Germany
ProdList: 6831
Advantage: 75

AppliChem GmbH

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Country: Germany
ProdList: 968
Advantage: 65

Service Chemical Inc.

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Country: Germany
ProdList: 6350
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Carl Roth GmbH & Co.KG

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Country: Germany
ProdList: 197
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cfm Oskar Tropitzsch

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View Lastest Price from Taxifolin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Taxifolin 480-18-2
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/Week
Release date: 2024-04-23

BINBO BIOLOGICAL CO.,LTD

Product: Taxifolin 480-18-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000 kg
Release date: 2024-11-27

Wuhan Haorong Biotechnology Co.,Ltd

Product: Taxifolin 480-18-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500
Release date: 2023-07-20

480-18-2, TaxifolinRelated Search:

Pinostrobin Quercetin dihydrate Paclitaxel Docetaxel PLUMBAGIN CASTICIN Chrysophanic acid Hypericin Oleanolic acid LYSIONOTIN TAXIFOLIN 3-O-RHAMNOSIDE alpha-Dihydroartemisinin Eurycoma longifolia powder extract Perilla oil Pterostilbene Quercetin 3,3',4',5',7-PENTAHYDROXYFLAVANONE (+)-3,3',4',5,7-PENTAHYDROXYFLAVANONE,3,3',4',5,7-PENTAHYDROXYFLAVANONE,3,5,7,3',4'-PENTAHYDROXYFLAVANONE

2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on

2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on(

2,3-dihydro-3,3’,4’,5,7-pentahydroxy-flavon

2theta-trans)-

3,3’,4’,5,7-pentahydroxy-flavanon

dihydro-querceti

distylin

TAXIFOLIN(P)

TAXIFOLIN, (+)-(RG)

taxifoliol

(2R-trans)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone

Dihydroquercetin,~99%

TAXIFOLIN SNAP-N-SHOOT 0.1mg/mL(P)

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-one

(+)-Taxifolin ,98%

(+)-trans Taxifolin

2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-

2-(3,4,5-Trihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-4H-1-benzopyran-4-one

(3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro

taxifolin or dihydroquercetin

CPD-474

trans dihydroquercetin

(2R,3R)-3,3′,4′,5,7-Pentahydroxyflavanone (2R,3R)-Dihydroquercetin

(2R,3R)-(+)-Taxifolin

(2R,3R)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-1-benzopyran-4-one

Diquertin

Lariksin

Lavitol

(+)-3,3',4',5,7-PENTAHYDROXYFLAVANONE

3,3',4',5,7-PENTAHYDROXYFLAVANONE

(2R,3R)-DIHYDROQUERCETIN

(2R,3R)-3,3',4',5,7-PENTAHYDROXYFLAVANONE

3,5,7,3',4'-PENTAHYDROXYFLAVANONE

(+)-DIHYDROQUERCETIN

DIHYDROQUERCETIN

(+)-TAXIFOLIN

TAXIFOLIN

TAXIFOLIN, (+)-

Taxifoliol,Distylin

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroMan-4-one

Taxifolin (Dihydroquercetin)

Taxifolin SynonyMs (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone

4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-

(2S,3S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-chromanone

3,3',4',5,7-Pentahydroxydihydroflavone

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R-trans)-

FLAVANONE, 3,3',4',5',7-PENTAHYDROXY

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-5-olate

Larch extract

Taxifolin，TAX

Taxifolin USP/EP/BP

(+)-(2R,3R)-Dihydroquercetin

(+)-Dihydroquercetin

Dihydroquercetin/Taxifolin

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one

(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one