TAXIFOLIN 3-O-RHAMNOSIDE

Product Name: TAXIFOLIN 3-O-RHAMNOSIDE
CAS No.: 29838-67-3
Chemical Name: TAXIFOLIN 3-O-RHAMNOSIDE
Synonyms: Astilbin;(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chroMen-3-yl 6-deoxy-alpha-L-Mannopyranoside;Loastilin;Astilbin-RM;Taxifolin 3-rhaMnoside;Taxifolin 3-o-rhamnoside;Astilbin (6CI, 7CI, 8CI);Dihydroquercetin 3-rhamnoside;Astilbin Taxifolin 3-O-rhaMnoside;Astilbin, 98%, from Smilax glabra Roxb.
CBNumber: CB7507018
Molecular Formula: C21H22O11
Formula Weight: 450.4
MOL File: 29838-67-3.mol

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TAXIFOLIN 3-O-RHAMNOSIDE Property

Melting point:: 180 °C (decomp)
Boiling point:: 801.1±65.0 °C(Predicted)
Density: 1.74
storage temp.: Sealed in dry,2-8°C
solubility: H2O: soluble1mg/mL, clear, colorless
pka: 7.34±0.60(Predicted)
form: A crystalline solid
color: White to off-white
Water Solubility: H2O: 1mg/mL, clear, colorless
InChIKey: ZROGCCBNZBKLEL-MQGABXIONA-N
SMILES: O([C@]1([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)[C@H]1C(C2=C(C=C(O)C=C2O[C@@H]1C1C=CC(O)=C(O)C=1)O)=O |&1:1,4,6,8,10,12,22,r|

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A2862
Product name: Astilbin from Engelhardtia roxburghiana
Purity: ≥98%
Packaging: 10mg
Price: $205
Updated: 2025/07/31

Cayman Chemical

Product number: 28267
Product name: Astilbin
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 28267
Product name: Astilbin
Packaging: 100mg
Price: $537
Updated: 2024/03/01

Cayman Chemical

Product number: 28267
Product name: Astilbin
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 28267
Product name: Astilbin
Packaging: 25mg
Price: $239
Updated: 2024/03/01

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TAXIFOLIN 3-O-RHAMNOSIDE Chemical Properties,Usage,Production

Description

Astilbin is a flavonoid that has been found in S. glabra and has diverse biological activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM. Astilbin (50 mg/kg) increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity. It reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson''s disease when administered at a dose of 50 mg/kg per day. Astilbin also reduces descent time in a pole test and increases traction test score in a mouse model of Parkinson''s disease, indicating reduced motor deficits. It reduces cell viability of MDA-MB-231 and MCF-7 cells (IC₅₀s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis when used at concentrations of 50 and 200 μM. Astilbin (20 mg/kg every other day for 14 days) reduces tumor growth in an MCF-7 mouse xenograft model.

Chemical Properties

White crystalline powder, soluble in boiling water, almost insoluble in ether, from Poria cocos, Sarsaparilla, yellow wolfberry Engelhardtia roxburghiana Wall. red velvet goat's foot.

Uses

Astilbin displays anti-depressant activity involving monoaminergic neurotransmitters an the BDNF signal pathway. Anti-oxidant.

Definition

ChEBI: A flavanone glycoside that is (+)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage.

in vivo

To explore whether Astilbin improves CDDP-induced nephrotoxicity in vivo, an acute cisplatin nephrotoxic mouse model is established. Single injection of CDDP with 8 mg/kg dose results in notable weight loss compared with control group. However, the phenomenon is significantly alleviated by Astilbin at dose of 50 mg/kg. The mice fed Astilbin alone do not show any obvious alteration in body weight. Similarly, serum creatinine (SCr) and blood urea nitrogen (BUN) are higher in CDDP-treated mice than in control group. Treatment with Astilbin also decreases SCr and BUN levels. To examine the protective effect of Astilbin on CDDP-induced renal histopathological damage, the mouse kidney sections are stained with H&E. The mice in control group and Astilbin treated group have normal kidney morphology, while kidneys in CDDP group show severe damage with tubular degeneration, necrosis and cystic dilatation of the tubules with focal hemorrhages. Administration of Astilbin mitigated kidney injury, resulting in lower histopathological score compared to CDDP group. The apoptosis of renal cells is also detected using TUNEL staining to determine whether Astilbin treatment decreased renal cell apoptosis in CDDP-induced acute nephrotoxic mice^[1].

IC 50

NRF2; NF-κB

References

[1] SI-WEI WANG . Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation[J]. Food and Chemical Toxicology, 2018, 114: Pages 227-236. DOI: 10.1016/j.fct.2018.02.041
[2] YING-LI ZHU . Neuroprotective effects of Astilbin on MPTP-induced Parkinson’s disease mice: Glial reaction, α-synuclein expression and oxidative stress[J]. International immunopharmacology, 2019, 66: Pages 19-27. DOI: 10.1016/j.intimp.2018.11.004
[3] XIAOQI SUN. Caspase-dependent mitochondrial apoptotic pathway is involved in astilbin-mediated cytotoxicity in breast carcinoma cells.[J]. Oncology reports, 2018, 40 4: 2278-2286. DOI: 10.3892/or.2018.6602

TAXIFOLIN 3-O-RHAMNOSIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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TAXIFOLIN 3-O-RHAMNOSIDE Suppliers

China 273 Germany 1 India 2 South Korea 1 United Kingdom 1 United States 15 Global 293

Sichuan Hongen Plant Technology Co., Ltd.

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Shenzhen Sungening Bio-Tech Co., Ltd

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Hangzhou Yuhao Chemical Technology Co., Ltd

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Dalian Meilun Biotech Co., Ltd.

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View Lastest Price from TAXIFOLIN 3-O-RHAMNOSIDE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: sucrose palmitate 29838-67-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kgs
Release date: 2025-11-21

Shaanxi Dideu New Materials Co. Ltd

Product: Astilbin Taxifolin 3-O-rhaMnoside 29838-67-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kgs
Release date: 2025-11-21

Hovane Phytochemicals Co., Ltd

Product: Astilbin 29838-67-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 80%HPLC
Supply Ability: 1 ton
Release date: 2024-11-11

29838-67-3, TAXIFOLIN 3-O-RHAMNOSIDERelated Search:

Swertiamarine Deacetyltaxol 7-EPI-10-DEACETYLTAXOL Cryptotanshinone Mogroside V PROCYANIDIN B2 Dioscin 7-Xylosyl-10-deacetyltaxol 7-Epitaxol Cephalomannine Forskolin SCUTELLAREIN CASTICIN Hydroxysafflor yellow A TAXIFOLIN 3-O-RHAMNOSIDE PINOBANKSIN DIHYDROKAEMPFEROL (2R,3R)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one

Taxifolin 3-o-rhamnoside

Astilbin

Astilbin Taxifolin 3-O-rhaMnoside

(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-chroMen-3-yl 6-deoxy-alpha-L-Mannopyranoside

Taxifolin 3-rhaMnoside

Astilbin froM Engelhardtia roxburghiana

Dihydroquercetin 3-rhamnoside

Astilbin, 98%, from Smilax glabra Roxb.

(2R,3R)-3-[(6-Deoxy-alpha-L-mannopyranosyloxy)]-2-(3,4-dihydroxy-phenyl)-2,3-dihydro-5,7-dihydroxy-4H-chromen-4-one

(2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one

(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one

4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-, (2R,3R)-

(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one

(2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)chroman-4-one

(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-3,4-dihy...

Astilbin (6CI, 7CI, 8CI)

Loastilin

Astilbin-RM

(2R,3R)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one

29838-67-3

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract