1-Methyl-4-pyrazole boronic acid pinacol ester

Product Name: 1-Methyl-4-pyrazole boronic acid pinacol ester
CAS No.: 761446-44-0
Chemical Name: 1-Methyl-4-pyrazole boronic acid pinacol ester
Synonyms: 1-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE;1-METHYLPYRAZOLE-4-BORONIC ACID PINACOL ESTER;1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-METHYL-1H-PYRAZOLE-4-BORONIC ACID PINACOL ESTER;1H-Pyrazole, 1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-4-(4;Angelica oil 8015-64-3;e-4-boronic acid pinacoL;1-Methylpyrazole-4-boroni...;1-Methyl-4-(4,4,5,5-Tetramethy
CBNumber: CB0414153
Molecular Formula: C10H17BN2O2
Formula Weight: 208.07
MOL File: 761446-44-0.mol

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1-Methyl-4-pyrazole boronic acid pinacol ester Property

Melting point:: 59-64 °C(lit.)
Boiling point:: 308.3±15.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (slightly), Methanol (Slightly)
pka: 2.09±0.10(Predicted)
form: Crystals
color: Off-white to yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3
InChIKey: UCNGGGYMLHAMJG-UHFFFAOYSA-N
SMILES: N1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
CAS DataBase Reference: 761446-44-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,F,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant/Flammable
TSCA: No
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 595314
Product name: 1-Methylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 1g
Price: $69.58
Updated: 2025/07/31

Sigma-Aldrich

Product number: 595314
Product name: 1-Methylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 5g
Price: $197
Updated: 2025/07/31

TCI Chemical

Product number: M2339
Product name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: M2339
Product name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $66
Updated: 2025/07/31

Sigma-Aldrich

Product number: 595314
Product name: 1-Methylpyrazole-4-boronic acid pinacol ester
Purity: 95%
Packaging: 25g
Price: $954
Updated: 2025/07/31

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1-Methyl-4-pyrazole boronic acid pinacol ester Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powde

Uses

suzuki reaction

Uses

1-Methyl-4-pyrazole boronic acid pinacol ester is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.

Synthesis

To the solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.40 g, 2.06 mmol) in THF (10 mL) was added NaH (0.1.00 g, 4.12 mmol) followed by methyl iodide (0.25 mL, 4.12 mmol) at 0° C and the reaction mixture was stirred at ambient temperature for 4 hr. The reaction was quenched with saturated NH4Cl solution (20 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and distilled under reduced pressure to obtain 1-Methyl-4-pyrazole boronic acid pinacol ester.

References

[1] Patent: WO2018/93569, 2018, A1. Location in patent: Page/Page column 189
[2] Patent: WO2009/155527, 2009, A2. Location in patent: Page/Page column 137-138
[3] Patent: WO2005/85227, 2005, A1. Location in patent: Page/Page column 90-91

1-Methyl-4-pyrazole boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Trimethyl borate Pinacol Potassium hydroxide 4-Bromopyrazole Tetrahydrofuran 5A molecular sieve Methyl bromide Iodomethane n-Butyllithium

Preparation Products

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1-Methyl-4-pyrazole boronic acid pinacol ester Suppliers

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View Lastest Price from 1-Methyl-4-pyrazole boronic acid pinacol ester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Methylpyrazole-4-boronic acid pinacol ester 761446-44-0
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-05

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 1-Methylpyrazole-4-boronic acid pinacol ester 761446-44-0
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-28

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Methyl-4-pyrazole boronic acid pinacol ester 761446-44-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-16

761446-44-0, 1-Methyl-4-pyrazole boronic acid pinacol esterRelated Search:

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1-Methylpyrazole-4-boronic acid pinacol ester (Related Reference)

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Angelica oil 8015-64-3

N-Methylpyrazole-4-boronicacidpinacolester

Tranexamic Acid Impurity 27-13C2

1-Methylpyrazole-4-boronic acid pinacol ester - [M0365]

761446-44-0

761446-18-6

76146-44-0

C10H17BN2O2

C10H19BN2O3

Boronate Esters

Boronic Acids and Derivatives

Chemical Synthesis

Heteroaryl Boronate Esters

Organometallic Reagents

Heterocyclic Building Blocks

Organoborons

Pyrazole