ChemicalBook > CAS DataBase List > 3,5-Difluorophenylboronic acid

3,5-Difluorophenylboronic acid

Product Name: 3,5-Difluorophenylboronic acid
CAS No.: 156545-07-2
Chemical Name: 3,5-Difluorophenylboronic acid
Synonyms: AKOS BRN-0091;RARECHEM AH PB 0167;3,5-Difluorophenylbo;3,5-DIFLUOROPHENYLBORONIC ACID;3,5-DIFLUOROBENZENEBORONIC ACID;3,5-Difluorobenzeneboronicacid98%;3,5-DIFLUOROPHENYLBORONIC ACID 98%;3,5-Difluorophenylboronic acid,98%;3,5-Difluorophenylboronic acid Cas;3,5-Difluorobenzeneboronic acid 98%
CBNumber: CB0437413
Molecular Formula: C6H5BF2O2
Formula Weight: 157.91
MOL File: 156545-07-2.mol

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3,5-Difluorophenylboronic acid Property

Melting point:: 210-217 °C (lit.)
Boiling point:: 266.9±50.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 6.46±0.10(Predicted)
form: powder
color: White to Orange to Green
BRN: 6800882
InChI: InChI=1S/C6H5BF2O2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,10-11H
InChIKey: QWQBQRYFWNIDOC-UHFFFAOYSA-N
SMILES: B(C1=CC(F)=CC(F)=C1)(O)O
CAS DataBase Reference: 156545-07-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn,F
Risk Statements: 36/37/38-20-19-11-22
Safety Statements: 26-36-33-16-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 471925
Product name: 3,5-Difluorophenylboronic acid
Packaging: 25g
Price: $287
Updated: 2025/07/31

Sigma-Aldrich

Product number: 471925
Product name: 3,5-Difluorophenylboronic acid
Packaging: 5g
Price: $60.5
Updated: 2024/03/01

TCI Chemical

Product number: D3081
Product name: 3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: D3081
Product name: 3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 25g
Price: $84
Updated: 2025/07/31

TRC

Product number: D450928
Product name: 3,5-Difluorophenylboronic acid
Packaging: 100g
Price: $415
Updated: 2021/12/16

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3,5-Difluorophenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White to beige-yellowish powder

Uses

Reactant involved in:• ;Synthesis of honokiol analogs as angiogenesis inhibitors1• ;Homo-coupling reactions2• ;Suzuki-Miyaura cross-coupling reactions3• ;Enantioselective borane reduction of trifluoroacetophenone4

Uses

suzuki reaction

Uses

3,5-Difluorophenylboronic Acid is used in the synthesis of N-thiazol-2-yl-benzamides as glucokinase (GK) activators for treatment of type 2 diabetes mellitus (T2DM).

Uses

Intermediates of Liquid Crystals

Synthesis

121-43-7

461-96-1

156545-07-2

(1) A solution was prepared by dissolving 100 g of 3,5-difluorobromobenzene in 150 mL of tetrahydrofuran (THF) under nitrogen protection. The solution was slowly added dropwise to a mixture containing 13.85 g of magnesium shavings and 55 mL of THF at a controlled titration rate to keep the reaction system at mild reflux. (2) After the dropwise addition was completed, the reaction mixture was stirred at 40°C for 1 hour and subsequently cooled in an ice bath. (3) A solution prepared from 64.59 g of trimethyl borate dissolved in 130 mL of THF was slowly added dropwise under ice bath cooling. After completion of the dropwise addition, the ice bath was removed and the reaction mixture was continued to be stirred at room temperature for 1 hour. (4) 10% hydrochloric acid solution was added dropwise to the reaction system until the system became acidic, followed by stirring at room temperature for 30 minutes. (5) The organic layer was separated and the aqueous layer was extracted with hexane. The organic layer and hexane extract were combined and washed with saturated saline. (6) The washed organic layer was dried by adding anhydrous sodium sulfate, filtered and distilled under reduced pressure to remove the solvent to obtain 71.65 g of 3,5-difluorophenylboronic acid.

References

[1] Patent: US5521192, 1996, A
[2] Patent: US6908914, 2005, B1
[3] Patent: EP2123623, 2009, A1. Location in patent: Page/Page column 43-44
[4] Patent: US2014/275577, 2014, A1. Location in patent: Paragraph 0094

3,5-Difluorophenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Difluorophenylboronic acid Suppliers

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View Lastest Price from 3,5-Difluorophenylboronic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3,5-Difluorophenylboronic acid 156545-07-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-28

Henan Fengda Chemical Co., Ltd

Product: (3,5-Difluorophenyl)boronic acid 156545-07-2
Price: US $6.00-0.60/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-18

Guangzhou Sunton Biotechnology Co., Ltd.

Product: 3,5-Difluorophenylboronic acid Cas 156545-07-2
Price: US $48.00-40.00/Kg
Min. Order: 10KG
Purity: 99
Supply Ability: 200tons
Release date: 2021-04-18

156545-07-2, 3,5-Difluorophenylboronic acidRelated Search:

4-Fluorobenzeneboronic acid 3,5-Dimethylphenylboronic acid Ethyl 2-(Chlorosulfonyl)acetate 1,3-Difluorobenzene Folic acid Florfenicol 3-Fluorophenylboronic acid Phenylboronic acid EPA 2,3,4,5,6-PENTAFLUOROBENZENEBORONIC ACID Transfluthrin Citric acid Ascoric Acid 3,4,5-Trifluorophenylboronic acid (3,5-DIFLUORO-2-METHOXYPHENYL)BORONIC ACID, 97 2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID 3,5-DIFLUORO-4-(HYDROXYMETHYL)PHENYLBORONIC ACID 3,5-DIFLUOROBENZENEBORONIC ACID NEOPENTYL GLYCOL CYCLIC ESTER

3,5-DIFLUOROBENZENEBORONIC ACID

3,5-DIFLUOROPHENYLBORONIC ACID

AKOS BRN-0091

RARECHEM AH PB 0167

Boronic acid, (3,5-difluorophenyl)- (9CI)

3,5-Difluorobenzeneboronic acid 98%

3,5-Difluorobenzeneboronicacid98%

3,5-DIFLUOROPHENYLBORONIC ACID 98%

3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride)

3,5-Difluorobenzeneboronic acid, 97+%

3,5-Difluorophenylboronic acid,98%

3,5-Difluorophenylboronic acid ,99%

3,5-Difluorophenylboronic acid, May contain varying amounts of anhydride, 97%

3,5-Difluorophenylbo

(3,5-Difluorophenyl)dihydroxyborane

Boronic acid, B-(3,5-difluorophenyl)-

3,5-Difluorophenylboronic acid Cas

3,5-Difluorophenylboronic acid - [D2700]

156545-07-2

F2C6H3BOH2

BORONIC ACID

Organometallic Reagents

Aryl

Boronic Acids

Boronic Acids and Derivatives

Liquid crystal intermediates

Aryl Boronic Acids

Boronic Acids and Derivatives

Chemical Synthesis

Disubstituted Aryl Boronic Acids

Organometallic Reagents

Boronic Acids

Boronic Acids and Derivatives

B (Classes of Boron Compounds)

Boronic Acids

Substituted Boronic Acids

Fluorin-contained phenyl boronic acid series

Boronic Acid

Aryl

Organoborons

HALIDE

blocks

BoronicAcids

FluoroCompounds

intermediate