3,5-Difluorophenylboronic acid
- Product Name
- 3,5-Difluorophenylboronic acid
- CAS No.
- 156545-07-2
- Chemical Name
- 3,5-Difluorophenylboronic acid
- Synonyms
- AKOS BRN-0091;RARECHEM AH PB 0167;3,5-Difluorophenylbo;3,5-DIFLUOROPHENYLBORONIC ACID;3,5-DIFLUOROBENZENEBORONIC ACID;3,5-Difluorobenzeneboronicacid98%;3,5-DIFLUOROPHENYLBORONIC ACID 98%;3,5-Difluorophenylboronic acid,98%;3,5-Difluorophenylboronic acid Cas;3,5-Difluorobenzeneboronic acid 98%
- CBNumber
- CB0437413
- Molecular Formula
- C6H5BF2O2
- Formula Weight
- 157.91
- MOL File
- 156545-07-2.mol
3,5-Difluorophenylboronic acid Property
- Melting point:
- 210-217 °C (lit.)
- Boiling point:
- 266.9±50.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 6.46±0.10(Predicted)
- form
- powder
- color
- White to Orange to Green
- BRN
- 6800882
- InChI
- InChI=1S/C6H5BF2O2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,10-11H
- InChIKey
- QWQBQRYFWNIDOC-UHFFFAOYSA-N
- SMILES
- B(C1=CC(F)=CC(F)=C1)(O)O
- CAS DataBase Reference
- 156545-07-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn,F
- Risk Statements
- 36/37/38-20-19-11-22
- Safety Statements
- 26-36-33-16-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 471925
- Product name
- 3,5-Difluorophenylboronic acid
- Packaging
- 25g
- Price
- $287
- Updated
- 2025/07/31
- Product number
- 471925
- Product name
- 3,5-Difluorophenylboronic acid
- Packaging
- 5g
- Price
- $60.5
- Updated
- 2024/03/01
- Product number
- D3081
- Product name
- 3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- D3081
- Product name
- 3,5-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- D450928
- Product name
- 3,5-Difluorophenylboronic acid
- Packaging
- 100g
- Price
- $415
- Updated
- 2021/12/16
3,5-Difluorophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
White to beige-yellowish powder
Uses
Reactant involved in:• ;Synthesis of honokiol analogs as angiogenesis inhibitors1• ;Homo-coupling reactions2• ;Suzuki-Miyaura cross-coupling reactions3• ;Enantioselective borane reduction of trifluoroacetophenone4
Uses
suzuki reaction
Uses
3,5-Difluorophenylboronic Acid is used in the synthesis of N-thiazol-2-yl-benzamides as glucokinase (GK) activators for treatment of type 2 diabetes mellitus (T2DM).
Uses
Intermediates of Liquid Crystals
Synthesis
121-43-7
461-96-1
156545-07-2
(1) A solution was prepared by dissolving 100 g of 3,5-difluorobromobenzene in 150 mL of tetrahydrofuran (THF) under nitrogen protection. The solution was slowly added dropwise to a mixture containing 13.85 g of magnesium shavings and 55 mL of THF at a controlled titration rate to keep the reaction system at mild reflux. (2) After the dropwise addition was completed, the reaction mixture was stirred at 40°C for 1 hour and subsequently cooled in an ice bath. (3) A solution prepared from 64.59 g of trimethyl borate dissolved in 130 mL of THF was slowly added dropwise under ice bath cooling. After completion of the dropwise addition, the ice bath was removed and the reaction mixture was continued to be stirred at room temperature for 1 hour. (4) 10% hydrochloric acid solution was added dropwise to the reaction system until the system became acidic, followed by stirring at room temperature for 30 minutes. (5) The organic layer was separated and the aqueous layer was extracted with hexane. The organic layer and hexane extract were combined and washed with saturated saline. (6) The washed organic layer was dried by adding anhydrous sodium sulfate, filtered and distilled under reduced pressure to remove the solvent to obtain 71.65 g of 3,5-difluorophenylboronic acid.
References
[1] Patent: US5521192, 1996, A
[2] Patent: US6908914, 2005, B1
[3] Patent: EP2123623, 2009, A1. Location in patent: Page/Page column 43-44
[4] Patent: US2014/275577, 2014, A1. Location in patent: Paragraph 0094
3,5-Difluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Difluorophenylboronic acid manufacturers
- Product
- 3,5-Difluorophenylboronic acid 156545-07-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-28
- Product
- (3,5-Difluorophenyl)boronic acid 156545-07-2
- Price
- US $6.00-0.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-18
- Product
- 3,5-Difluorophenylboronic acid Cas 156545-07-2
- Price
- US $48.00-40.00/Kg
- Min. Order
- 10KG
- Purity
- 99
- Supply Ability
- 200tons
- Release date
- 2021-04-18