7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

Product Name: 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
CAS No.: 15421-84-8
Chemical Name: 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
Synonyms: ar12008;Trapymin;TRAPIDIL;Avantrin;rocornal;Trapymine;Trapidil CRS;Trapidil (AR12008);Trapidil >=98% (HPLC);5-methyl-7-diaethylamino-s-triazolo(1.5-a)pyrimidin
CBNumber: CB0487317
Molecular Formula: C10H15N5
Formula Weight: 205.26
MOL File: 15421-84-8.mol

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7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Property

Melting point:: 98-99.4° (Pfeifer); 102-104° from heptane (Tenor)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: H2O: ≥15mg/mL
pka: pKs = 2.79(at 25℃)
form: powder
color: white to tan
CAS DataBase Reference: 15421-84-8

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
Toxicity: LD50 in mice, rats (mg/kg): 115, 76 i.v.; 380, 235 orally; 155, 100 i.p.; 132, 100 s.c. (Fuller)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0071
Product name: Trapidil
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $474
Updated: 2022/05/15

Sigma-Aldrich

Product number: T1820000
Product name: Trapidil
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: t1820000
Price: $223
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FD153326
Product name: N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-4529
Product name: Trapidil
Purity: >98.0%
Packaging: 10mg
Price: $84
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153326
Product name: N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
Packaging: 250mg
Price: $100
Updated: 2021/12/16

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7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder

Originator

Rocornal,Mochida,Japan,1978

Uses

Vasodilator;PDGF antagonist

Definition

ChEBI: Trapidil is a member of triazolopyrimidines.

Manufacturing Process

8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30 cc of water and 7.3 g of diethylamine added. After 2 hours heating with stirring, the mixture was concentrated under vacuum. The residue was recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7- diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to 104°C. The hydrochloride produced in the usual manner had a melting point of 212°C.

Therapeutic Function

Coronary vasodilator

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A coronary vasodilator. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Phosphorus oxychloride Diethylamine 3-Amino-1,2,4-Triazole Acetic acid

Preparation Products

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7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Suppliers

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View Lastest Price from 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE manufacturers

airuikechemical co., ltd.

Product: Trapidil 15421-84-8
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-03

Shaanxi Dideu Medichem Co. Ltd

Product: Trapidil 15421-84-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

15421-84-8, 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINERelated Search:

Lonidamine 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Diethylamine [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE Bumepidil 4-(5-CHLOROMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BUTTPARK 126\40-87 BUTTPARK 54\40-31 5-METHYL-8-(2-PIPERIDINOETHYL)-7,8-DIHYDRO-6H-PYRROLO[3,2-E][1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE BUTTPARK 126\40-85 BUTTPARK 54\40-28 5-METHYL-7-PIPERAZIN-1-YL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE BUTTPARK 126\40-84 BUTTPARK 57\40-36 BUTTPARK 54\40-30 BUTTPARK 54\40-29 BUTTPARK 113\40-54 8-(4-METHOXYBENZYL)-5-METHYL-7,8-DIHYDRO-6H-PYRROLO[3,2-E][1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE

TRAPIDIL

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

7-Diethylamino-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine

N,N-Diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Trapymin

N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine

7-(Diethylamino)-5-methyl-S-triazolo[1,5-a]pyrimidine ,98%

Avantrin

Trapymine

[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine,N,N-diethyl-5-methyl-

5-a)pyrimidin-7-amine,n,n-diethyl-5-methyl-s-triazolo(

5-methyl-7-diaethylamino-s-triazolo(1.5-a)pyrimidin

5-methyl-7-diethylamino-s-triazolo-(1,5-a)-pyrimidine

ar12008

n,n-diethyl-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidine-7-amine

rocornal

Trapidil CRS

Trapidil >=98% (HPLC)

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE USP/EP/BP

Trapidil (AR12008)

N,N-Diethyl-4-methyl-1,5,7,9-Tetrazabicyclo[4.3.0]Nona-2,4,6,8-Tetraen-2-Amine

15421-84-8