5-Bromo-2-chloronicotinic acid
- Product Name
- 5-Bromo-2-chloronicotinic acid
- CAS No.
- 29241-65-4
- Chemical Name
- 5-Bromo-2-chloronicotinic acid
- Synonyms
- 5-Bromo-2-Chloronicotinic;5-BROMO-2-CHLORONICOTINIC ACID;5-Bromo-2-chloronicotinic acid 97%;5-Bromo-2-chloronicotinic Acid >5-Bromo-2-chloronicotinic acid ,97%;5-bromo-2-chloropyridine-3-carboxylicaci;5-Bromo-2-chlorpyridine-3-carboxylic acid;5 - broMine - 2 - nicotinic acid chloride;5-Bromo-2-chloropyridin-3-carboxylic acid;5-BROMO-2-CHLORO-3-PYRIDINECARBOXYLIC ACID
- CBNumber
- CB0492683
- Molecular Formula
- C6H3BrClNO2
- Formula Weight
- 236.45
- MOL File
- 29241-65-4.mol
5-Bromo-2-chloronicotinic acid Property
- Melting point:
- 173-176°C
- Boiling point:
- 345.1±42.0 °C(Predicted)
- Density
- 1.917±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- soluble in Methanol
- form
- Solid
- pka
- 1.61±0.25(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C6H3BrClNO2/c7-3-1-4(6(10)11)5(8)9-2-3/h1-2H,(H,10,11)
- InChIKey
- UKNYSJCAGUXDOQ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Br)C=C1C(O)=O
- CAS DataBase Reference
- 29241-65-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant/Keep Cold
- HazardClass
- IRRITANT, KEEP COLD
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B3883
- Product name
- 5-Bromo-2-chloronicotinic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $86
- Updated
- 2025/07/31
- Product number
- B684108
- Product name
- 5-Bromo-2-chloronicotinic Acid
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B684108
- Product name
- 5-Bromo-2-chloronicotinic Acid
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB75489
- Product name
- 5-Bromo-2-chloronicotinic Acid
- Packaging
- 50g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 4H21-D-X0
- Product name
- 5-Bromo-2-chloronicotinic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $39
- Updated
- 2021/12/16
5-Bromo-2-chloronicotinic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Synthesis
104612-36-4
29241-65-4
Step B. Synthesis of 5-bromo-2-chloronicotinic acid. A mixture of 5-bromo-2-hydroxynicotinic acid (32.9 g, 0.151 mol), dichlorosulfoxide (167 mL), and N,N-dimethylformamide (10.5 mL) was heated to reflux for 4 hours at 70°C. The reaction was carried out with the addition of water. Upon completion of the reaction, the mixture was concentrated, cooled to 0°C, and the reaction was quenched by the slow addition of water to give an off-white precipitate. The precipitate was stirred in water for 1 h and subsequently collected by filtration and dried under vacuum to give 5-bromo-2-chloronicotinic acid (35.5 g, 99% yield). The product can be used directly in the subsequent reaction without further purification or can be purified by recrystallization in hot water. Mass spectrum (electrospray ionization): calculated value C6H3BrClNO2, 234.90; measured value m/z, 236.2 [M + H]+. 1H NMR (acetone-d6): δ 8.66 (d, J = 2.5 Hz, 1H), 8.43 (d, J = 2.5 Hz, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2566 - 2569
[2] Patent: US2006/287292, 2006, A1. Location in patent: Page/Page column 26
[3] European Journal of Organic Chemistry, 2010, # 28, p. 5397 - 5401
[4] Synthetic Communications, 1989, vol. 19, # 3and4, p. 553 - 560
[5] Patent: WO2010/136817, 2010, A1. Location in patent: Page/Page column 113
5-Bromo-2-chloronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-2-chloronicotinic acid Suppliers
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- Country
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View Lastest Price from 5-Bromo-2-chloronicotinic acid manufacturers
- Product
- 5-Bromo-2-chloronicotinic acid 29241-65-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
- Product
- 5-Bromo-2-chloronicotinic acid 29241-65-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- 5-Bromo-2-chloronicotinic acid 29241-65-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11